{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:37:01Z","timestamp":1790696221755,"version":"4.1.0"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T00:00:00Z","timestamp":1608249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> This study evaluated iron overload after intracerebral hemorrhage (ICH) using ESWAN sequences.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> This single-center prospective observational cohort study enrolled supratentorial ICH patients. MRI was obtained with a 3.0-T scanner at day 1, day 14, day 30, and follow-up (300 days or later). R2* mapping was generated based on the ESWAN. R2* value of the ipsilateral side represented iron deposition, and the R2* value of the contralateral side served as control. R2* value was adjusted by volume and used to assess total iron overload. Brain edema was measured on T2 FLAIR-weighted images. Brain atrophy was calculated as the contralateral hemisphere volume minus the injured hemisphere volume.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Twnety-seven patients with a spontaneous supratentorial ICH were included in this analysis. The ipsilateral R2* value was 40.27 \u00b1 11.62, 41.92 \u00b1 13.56, and 60.89 \u00b1 14.09 at days 1, 14, and 30, respectively. The R2* value was significantly higher in the ICH side than the contralateral side (<jats:italic>p<\/jats:italic> &amp;lt; 0.01). Increased R2* value was seen on day 30 compared to day 14 (<jats:italic>p<\/jats:italic> &amp;lt; 0.01). The R2* value showed logistic decay with the distance to the hematoma margin (<jats:italic>p<\/jats:italic> &amp;lt; 0.01). Brain edema at day 14 and brain atrophy at follow-up correlated with R2* value adjusted by volume at day 14 (<jats:italic>p<\/jats:italic> &amp;lt; 0.01).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> After ICH, the iron deposition in the perihematomal region was progressively increased during the first month. R2* value adjusted by volume predicted acute brain edema and chronic brain atrophy.<\/jats:p>","DOI":"10.3389\/fneur.2020.602413","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T06:21:20Z","timestamp":1608272480000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Association of Brain Iron Overload With Brain Edema and Brain Atrophy After Intracerebral 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