{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:23:35Z","timestamp":1788175415212,"version":"build-2803163510"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T00:00:00Z","timestamp":1610409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Silent and overt ischemic brain lesions are common and associated with adverse outcome. Whether the CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>-VASc score and its components predict magnetic resonance imaging (MRI)-detected ischemic silent and overt brain lesions in patients with atrial fibrillation (AF) is unclear.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> In this cross-sectional analysis, patients with AF were enrolled in a multicenter cohort study in Switzerland. Outcomes were clinically overt, silent [in the absence of a history of stroke\/transient ischemic attack (TIA)] and any MRI-detected ischemic brain lesions. Logistic regression analyses were performed to assess the relationship of the CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>-VASc score and its components with ischemic brain lesions. An adapted CHA<jats:sub>2<\/jats:sub>D-VASc score (excluding history of stroke\/TIA) for the analyses of clinically overt and silent ischemic brain lesions was used.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Overall, 1,741 patients were included in the analysis (age 73 \u00b1 8 years, 27.4% female). At least one ischemic brain lesion was observed in 36.8% (clinically overt: 10.5%; silent: 22.9%; transient ischemic attack: 3.4%). The CHA<jats:sub>2<\/jats:sub>D-VASc score was strongly associated with clinically overt and silent ischemic brain lesions {odds ratio (OR) [95% confidence interval (CI)] 1.32 (1.17\u20131.49), <jats:italic>p<\/jats:italic> &amp;lt; 0.001 and 1.20 (1.10\u20131.30), <jats:italic>p<\/jats:italic> &amp;lt; 0.001, respectively}. Age 65\u201374 years (OR 2.58; 95%CI 1.29\u20135.90; <jats:italic>p<\/jats:italic> = 0.013), age \u226575 years (4.13; 2.07\u20139.43; <jats:italic>p<\/jats:italic> &amp;lt; 0.001), hypertension (1.90; 1.28\u20132.88; <jats:italic>p<\/jats:italic> = 0.002) and diabetes (1.48; 1.00\u20132.18; <jats:italic>p<\/jats:italic> = 0.047) were associated with clinically overt brain lesions, whereas age 65\u201374 years (1.95; 1.26\u20133.10; <jats:italic>p<\/jats:italic> = 0.004), age \u226575 years (3.06; 1.98\u20134.89; <jats:italic>p<\/jats:italic> &amp;lt; 0.001) and vascular disease (1.39; 1.07\u20131.79; <jats:italic>p<\/jats:italic> = 0.012) were associated with silent ischemic brain lesions.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> A higher CHA<jats:sub>2<\/jats:sub>D-VASc score was associated with a higher risk of both overt and silent ischemic brain lesions.<\/jats:p><jats:p><jats:bold>Clinical Trial Registration:<\/jats:bold><jats:ext-link>www.ClinicalTrials.gov<\/jats:ext-link>, identifier: NCT02105844.<\/jats:p>","DOI":"10.3389\/fneur.2020.609234","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T07:37:42Z","timestamp":1610523462000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Association of the CHA2D(S2)-VASc Score and Its Components With Overt and Silent Ischemic Brain Lesions in Patients With Atrial Fibrillation"],"prefix":"10.3389","volume":"11","author":[{"given":"Fabienne","family":"Steiner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal 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