{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T11:57:42Z","timestamp":1764331062064,"version":"3.41.2"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>COVID-19 is typically associated with fever and severe respiratory symptoms including dry cough and dyspnea. However, COVID-19 may also affect both central and peripheral nervous systems. To date, the incidence rate of spinal cord involvement in COVID-19 is not known and the pathogenesis is still not fully understood. We report here two female patients admitted to Assiut University Hospitals\/Egypt during the period from first of July to August 10, 2020. Both presented with a positive SARS-CoV-2 polymerase chain reaction (PCR) nasopharyngeal swab, elevated serum <jats:sc>d<\/jats:sc>-dimer and ferritin levels, and bilateral ground glass appearance in a CT chest scan. The first was a 60-year-old female with acute onset of flaccid paraplegia 10 days after flu-like symptoms, in whom MRI revealed transverse myelitis. The second was a 21-year-old female with symptoms of acute quadriplegia, fever, headache, and anosmia in whom an MRI scan revealed long cervico-thoracic myelopathy. Anterior spinal artery occlusion and possibly transverse myelitis were considered as differential diagnosis of long segment myelopathy.<\/jats:p>","DOI":"10.3389\/fneur.2020.610648","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T13:37:31Z","timestamp":1608644251000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Case Report: Acute Spinal Cord Myelopathy in Patients With COVID-19"],"prefix":"10.3389","volume":"11","author":[{"given":"Eman M.","family":"Khedr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed A.","family":"Karim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radwa K.","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,12,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/s1474-4422(20)30221-0","article-title":"Neurological associations of COVID-19","volume":"19","author":"Ellul","year":"2020","journal-title":"Lancet Neurol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1016\/j.radcr.2020.06.001","article-title":"Acute myelitis as a neurological complication of COVID-19: a case report and MRI findings","volume":"15","author":"AlKetbi","year":"2020","journal-title":"Radiol Case Rep."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2196","DOI":"10.1007\/s00415-020-09934-w","article-title":"Acute transverse myelitis after COVID-19 pneumonia","volume":"267","author":"Munz","year":"2020","journal-title":"J Neurol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"321","DOI":"10.5811\/cpcem.2020.5.47937","article-title":"A case report of acute transverse myelitis following novel coronavirus infection","volume":"4","author":"Sarma","year":"2020","journal-title":"Clin Pract Cases Emerg Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"e803","DOI":"10.1212\/nxi.0000000000000803","article-title":"COVID-19-associated acute necrotizing myelitis","volume":"7","author":"Sotoca","year":"2020","journal-title":"Neurol Neuroimmunol Neuroinflamm."},{"key":"B6","doi-asserted-by":"publisher","first-page":"417","DOI":"10.2174\/157015911796557948","article-title":"Idiopathic transverse myelitis and neuromyelitis optica: clinical profiles, pathophysiology and therapeutic choices","volume":"9","author":"Awad","year":"2011","journal-title":"Curr Neuropharmacol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1212\/01.wnl.0000260970.63493.c8","article-title":"Idiopathic transverse myelitis: corticosteroids, plasma exchange, or cyclophosphamide","volume":"68","author":"Greenberg","year":"2007","journal-title":"Neurology."},{"key":"B8","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/978-81-322-1777-0_6","article-title":"Neuroinvasive and neurotropic human respiratory coronaviruses: potential neurovirulent agents in humans","volume":"807","author":"Desforges","year":"2014","journal-title":"Adv Exp Med Biol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3390\/v12010014","article-title":"Human coronaviruses and other respiratory viruses: underestimated opportunistic pathogens of the central nervous system?","volume":"12","author":"Desforges","year":"2019","journal-title":"Viruses"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1111\/ene.14277","article-title":"Does SARS-Cov-2 invade the brain? 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