{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T22:42:36Z","timestamp":1789512156278,"version":"build-2803163510"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:00:00Z","timestamp":1611187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> The purpose of the present study was to evaluate the dynamics of endolymphatic hydrops (EH) and symptoms in a group of patients who underwent endolymphatic duct blockage (EDB) for treatment of intractable Meniere's Disease (MD), and to explore a metric for verifying the effectiveness of EDB procedure.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A total of 22 patients with intractable MD patients who underwent EDB participated in the present study. EH was visualized using locally enhanced inner ear magnetic resonance imaging (MRI) prior to and following surgery. The vestibular hydrops ratio (VHR) in the second MRI examination was compared with the pre-surgery recordings.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Following EDB, 6 patients exhibited complete or partial reversal of EH, complete control of vertigo spells and reported improvement in hearing; 13 patients showed no changes in EH or hearing, but 5 of these patients exhibited complete control of vertigo attacks, and the other 8 patients exhibited improved control of vertigo attacks. The final 3 patients showed an increase in EH, but symptomatic worsening in 2 patients, and symptomatic improvement in 1 patient. There was a significant difference in the average VHR prior to and following EDB. Postoperative VHR was positively correlated with the frequency of vertigo spells in the latest 6 months of follow-up and improvement of postoperative average hearing threshold.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The decreased EH accompanying the reduction in vertigo attacks and hearing preservation may provide a metric for verifying the effectiveness of EDB treatment in patients with MD.<\/jats:p>","DOI":"10.3389\/fneur.2020.622760","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T07:01:25Z","timestamp":1611212485000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Dynamics in Endolymphatic Hydrops &amp; Symptoms in Meniere's Disease After Endolymphatic Duct Blockage, Preliminary Results"],"prefix":"10.3389","volume":"11","author":[{"given":"Jun","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anquan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjiao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huang","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,1,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3109\/00016489109128047","article-title":"Long-term progression of Meni\u00e9re's disease","volume":"485","author":"Stahle","year":"1991","journal-title":"Acta Otolaryngol Suppl."},{"key":"B2","doi-asserted-by":"publisher","first-page":"301","DOI":"10.2147\/TCRM.S59023","article-title":"Optimal management of M\u00e9ni\u00e8re's disease","volume":"11","author":"Foster","year":"2015","journal-title":"Ther Clin Risk Manag."},{"key":"B3","first-page":"29","article-title":"The natural history of Meni\u00e8re's disease. In: Harris JP, editor","volume-title":"Meni\u00e8re's Disease.","author":"Harris","year":"1999"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1017\/S0022215100118365","article-title":"The saccus endolymphaticus and an operation for draining the same for the relief of vertigo 1927","volume":"105","author":"Portmann","year":"1991","journal-title":"J Laryngol Otol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1001\/archotol.1981.00790410009002","article-title":"Placebo effect in surgery for M\u00e9ni\u00e8re's disease. A double-blind, placebo-controlled study on endolymphatic sac shunt surgery","volume":"107","author":"Thomsen","year":"1981","journal-title":"Arch Otolaryngol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1177\/000348948609500107","article-title":"Endolymphatic sac-mastoid shunt surgery. A nonspecific treatment modality?","volume":"95","author":"Thomsen","year":"1986","journal-title":"Ann Otol Rhinol Laryngol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1097\/00129492-198907000-00002","article-title":"Placebo effect in surgery for Meni\u00e8re's disease: nine-year follow-up","volume":"10","author":"Bretlau","year":"1989","journal-title":"Am J Otol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1080\/00016489.1992.11665422","article-title":"Immunohistochemical characterization of the human endolymphatic sac and its associated cell populations","volume":"112","author":"Altermatt","year":"1992","journal-title":"Acta Otolaryngol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1177\/000348949110000211","article-title":"Ultrastructural evidence of a merocrine secretion in the human endolymphatic sac","volume":"100","author":"Rask-Andersen","year":"1991","journal-title":"Ann Otol Rhinol Laryngol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1177\/019459989010200618","article-title":"Re-evaluation of the role of the human endolymphatic sac in Meni\u00e8re's disease","volume":"102","author":"Wackym","year":"1990","journal-title":"Otolaryngol Head Neck Surg."},{"key":"B11","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1177\/0194599818756829","article-title":"M\u00e9ni\u00e8re's disease pathophysiology: endolymphatic sac immunohistochemical study of aquaporin-2, V2R vasopressin receptor, NKCC2, and TRPV4","volume":"158","author":"Asmar","year":"2018","journal-title":"Otolaryngol Head Neck Surg."},{"key":"B12","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1080\/00016489.2018.1481524","article-title":"Endolymphatic duct blockage for refractory M\u00e9ni\u00e8re's disease: assessment of intraoperative CSF leak on short-term surgical outcomes","volume":"138","author":"Saliba","year":"2018","journal-title":"Acta Otolaryngol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1177\/003591573803101112","article-title":"Observations on the pathology of M\u00e9ni\u00e8re's syndrome: (Section of otology)","volume":"31","author":"Hallpike","year":"1938","journal-title":"Proc R Soc Med."},{"key":"B14","first-page":"2310","article-title":"Hearing organ of a patient who showed Meniere's symptoms","volume":"44","author":"Yamakawa","year":"1938","journal-title":"J Otolaryngol Soc Jpn."},{"key":"B15","doi-asserted-by":"publisher","first-page":"151","DOI":"10.3174\/ajnr.A4462","article-title":"Endolymphatic hydrops reversal following acetazolamide therapy: demonstration with delayed intravenous contrast-enhanced 3D-FLAIR MRI","volume":"37","author":"Sepahdari","year":"2016","journal-title":"AJNR Am J Neuroradiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.3109\/00016489.2013.831480","article-title":"Effects of endolymphatic sac decompression surgery on endolymphatic hydrops","volume":"133","author":"Fukushima","year":"2013","journal-title":"Acta Otolaryngol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s11604-014-0290-4","article-title":"Visualization of endolymphatic hydrops with MR imaging in patients with M\u00e9ni\u00e8re's disease and related pathologies: current status of its methods and clinical significance","volume":"32","author":"Naganawa","year":"2014","journal-title":"Jpn J Radiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1007\/s00330-008-0854-8","article-title":"Separate visualization of endolymphatic space, perilymphatic space and bone by a single pulse sequence; 3D-inversion recovery imaging utilizing real reconstruction after intratympanic Gd-DTPA administration at 3 Tesla","volume":"18","author":"Naganawa","year":"2008","journal-title":"Eur Radiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3233\/VES-150549","article-title":"Diagnostic criteria for Meni\u00e8re's disease","volume":"25","author":"Lopez-Escamez","year":"2015","journal-title":"J Vestib Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1007\/s00405-012-2087-3","article-title":"Effect of standard-dose betahistine on endolymphatic hydrops: an MRI pilot study","volume":"270","author":"G\u00fcrkov","year":"2013","journal-title":"Eur Arch Otorhinolaryngol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1186\/s12880-020-00504-0","article-title":"Value of CT and three-dimensional reconstruction revealing specific radiological signs for screening causative high jugular bulb in patients with Meniere's disease","volume":"20","author":"Hu","year":"2020","journal-title":"BMC Med Imaging."},{"key":"B22","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1080\/00016480902729827","article-title":"Grading of endolymphatic hydrops using magnetic resonance imaging","volume":"560","author":"Nakashima","year":"2009","journal-title":"Acta Otolaryngol Suppl."},{"key":"B23","doi-asserted-by":"publisher","first-page":"924","DOI":"10.3109\/00016489.2013.795290","article-title":"Changes in endolymphatic hydrops after sac surgery examined by Gd-enhanced MRI","volume":"133","author":"Uno","year":"2013","journal-title":"Acta Otolaryngol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"434","DOI":"10.3109\/00016489.2012.753640","article-title":"Magnetic resonance imaging of the inner ear after both intratympanic and intravenous gadolinium injections","volume":"133","author":"Iida","year":"2013","journal-title":"Acta Otolaryngol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1097\/MAO.0b013e31819bda66","article-title":"Individual differences in the permeability of the round window: evaluating the movement of intratympanic gadolinium into the inner ear","volume":"30","author":"Yoshioka","year":"2009","journal-title":"Otol Neurotol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1097\/MAO.0b013e3181a66d2b","article-title":"Middle ear exploration in patients with M\u00e9ni\u00e8re's disease who have failed outpatient intratympanic gentamicin therapy","volume":"30","author":"Crane","year":"2009","journal-title":"Otol Neurotol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"2965","DOI":"10.1007\/s00405-015-3890-4","article-title":"Endolymphatic duct blockage: quality of life assessment of a novel surgical technique for M\u00e9ni\u00e8re disease","volume":"273","author":"Gabra","year":"2016","journal-title":"Eur Arch Otorhinolaryngol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1177\/0194599814555840","article-title":"Endolymphatic duct blockage: a randomized controlled trial of a novel surgical technique for M\u00e9ni\u00e8re's disease treatment","volume":"152","author":"Saliba","year":"2015","journal-title":"Otolaryngol Head Neck Surg."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1007\/s00405-011-1573-3","article-title":"In vivo visualization of endolyphatic hydrops in patients with Meniere's disease: correlation with audiovestibular function","volume":"268","author":"G\u00fcrkov","year":"2011","journal-title":"Eur Arch Otorhinolaryngol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1002\/lary.25576","article-title":"The correlation between symptoms of definite Meniere's disease and endolymphatic hydrops visualized by magnetic resonance imaging","volume":"126","author":"Wu","year":"2016","journal-title":"Laryngoscope."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1097\/MAO.0000000000001144","article-title":"High resolution MRI shows presence of endolymphatic hydrops in patients still symptomatic after endolymphatic shunt surgery","volume":"37","author":"Liu","year":"2016","journal-title":"Otol Neurotol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"46","DOI":"10.3389\/fneur.2019.00046","article-title":"Three-dimensional magnetic resonance imaging reveals the relationship between the control of vertigo and decreases in endolymphatic hydrops after endolymphatic sac drainage with steroids for Meniere's disease","volume":"10","author":"Ito","year":"2019","journal-title":"Front Neurol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1080\/00016489.2019.1630757","article-title":"Relationship between changes in hearing function and volumes of endolymphatic hydrops after endolymphatic sac drainage","volume":"139","author":"Ito","year":"2019","journal-title":"Acta Otolaryngol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.anl.2018.10.011","article-title":"Change in endolymphatic hydrops 2 years after endolymphatic sac surgery evaluated by MRI","volume":"46","author":"Higashi-Shingai","year":"2019","journal-title":"Auris Nasus Larynx."},{"key":"B35","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1097\/MAO.0000000000002502","article-title":"On the relationship between Meni\u00e8re's disease and endolymphatic hydrops","volume":"41","author":"Gluth","year":"2020","journal-title":"Otol Neurotol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.anl.2019.09.005","article-title":"A possible mechanism of the formation of endolymphatic hydrops and its associated inner ear disorders","volume":"47","author":"Takeda","year":"2020","journal-title":"Auris Nasus Larynx."},{"key":"B37","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1002\/lary.25579","article-title":"Prognostic implications of and audiometric evidence for hearing fluctuation in Meniere's disease","volume":"125","author":"Hoa","year":"2015","journal-title":"Laryngoscope."},{"key":"B38","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1097\/00129492-200501000-00013","article-title":"Pathophysiology of Meniere's syndrome: are symptoms caused by endolymphatic hydrops?","volume":"26","author":"Merchant","year":"2005","journal-title":"Otol Neurotol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"303","DOI":"10.3389\/fneur.2019.00303","article-title":"Endotype-phenotype patterns in Meniere's disease based on gadolinium-enhanced MRI of the vestibular aqueduct","volume":"10","author":"B\u00e4chinger","year":"2019","journal-title":"Front Neurol."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2020.622760\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T07:01:28Z","timestamp":1611212488000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2020.622760\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,21]]},"references-count":39,"alternative-id":["10.3389\/fneur.2020.622760"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2020.622760","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,21]]},"article-number":"622760"}}