{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:38:16Z","timestamp":1791376696541,"version":"4.3.2"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Parkinson's disease (PD) and sarcopenia are two common diseases in aging people. To date, the prevalence of sarcopenia in PD patients and the relationship between clinical features and sarcopenia in PD patients are not clear. The aim of the study was to (1) assess the prevalence of sarcopenia in PD patients and (2) reveal the clinical features between PD patients with and without sarcopenia.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Method:<\/jats:bold>\n                    A systematic review was carried out through screening PubMed, EMBASE, and Cochrane database in May 2020. All study designs (case\u2013control, cohort, and cross-sectional studies) were eligible for meta-analysis. Data of patients' characteristics, sarcopenia criteria, sarcopenia prevalence, and sarcopenia measures were retrieved. The primary outcome was estimated prevalence of sarcopenia by a pooled prevalence (%) and its 95% confidence interval (CI), using a random-effects model. The secondary outcome was the differences in clinical features between PD patients with and without sarcopenia by meta-analysis. Included articles were assessed for risk of bias. Potential sources of variation were investigated by using subgroup analyses and meta-regression.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Result:<\/jats:bold>\n                    Ten studies were included in the review. Among them, nine were cross-sectional studies, and one was a prospective cohort study. Age of participants with PD in the studies ranged from 51.1 to 80.7 years. The estimated prevalence of sarcopenia ranged from 6 to 55.5%. The random-effects pooled prevalence was 29% (95% CIs: 0.18\u20130.40). When only studies at low risk of bias were considered, pooled prevalence decreased to 17% (95% CIs: 0.02\u20130.33), with still high heterogeneity. The incidence of falls in PD patients with sarcopenia was higher than that in PD patients without sarcopenia. There was no difference in sex ratio between PD patients with and without sarcopenia.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Sarcopenia seems to be common in patients with PD. Early assessment of sarcopenia should be implemented in PD to avoid fall and disability.\n                  <\/jats:p>","DOI":"10.3389\/fneur.2021.598035","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:36:26Z","timestamp":1614904586000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":80,"title":["Sarcopenia in Patients With Parkinson's Disease: A Systematic Review and Meta-Analysis"],"prefix":"10.3389","volume":"12","author":[{"given":"Yingying","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruwei","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifang","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,3,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1002\/mds.22789","article-title":"Understanding disability in Parkinson's disease","volume":"25","author":"Shulman","year":"2010","journal-title":"Mov Disord."},{"key":"B2","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.jamda.2016.06.001","article-title":"Sarcopenia is recognized as an independent condition by an International Classification of Disease, Tenth Revision, Clinical Modification (ICD-10-CM) Code","volume":"17","author":"Cao","year":"2016","journal-title":"J Am Med Dir Assoc."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1007\/s10072-018-3439-6","article-title":"Incidence of sarcopenia and dynapenia according to stage in patients with idiopathic Parkinson's disease","volume":"39","author":"Yazar","year":"2018","journal-title":"Neurol Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000505590","article-title":"Interrelation between sarcopenia and the number of motor neurons in patients with Parkinsonian syndromes","volume":"21","author":"Krenovsky","year":"2020","journal-title":"Gerontology."},{"key":"B5","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/978-3-319-57379-3_19","article-title":"Sarcopenia and its impact on quality of life","volume":"987","author":"Tsekoura","year":"2017","journal-title":"Adv Exp Med Biol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"24","DOI":"10.13140\/RG.2.2.11364.88960","article-title":"Sarcopenia and the new ICD-10-CM code: screening, staging, and diagnosis considerations","volume":"34","author":"Falcon","year":"2017","journal-title":"Fed Pract."},{"key":"B7","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1093\/ageing\/afq034","article-title":"Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People","volume":"39","author":"Cruz-Jentoft","year":"2010","journal-title":"Age Ageing."},{"key":"B8","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1093\/ageing\/afz046","article-title":"Sarcopenia: revised European consensus on definition and diagnosis","volume":"48","author":"Cruz-Jentoft","year":"2019","journal-title":"Age Ageing."},{"key":"B9","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.jamda.2011.01.003","article-title":"Sarcopenia: an undiagnosed condition in older adults. 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