{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T01:46:14Z","timestamp":1774921574333,"version":"3.50.1"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T00:00:00Z","timestamp":1618272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> This study aimed to analyze the clinical features of myasthenia gravis (MG) in combination with the afterdischarges and compare the characteristics of afterdischarges in MG with different serum antibodies.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Ninety-two patients with MG were analyzed retrospectively. The afterdischarges were investigated using motor nerve conduction examination, F-wave examination, and repetitive nerve stimulation (RNS).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Afterdischarges were observed after the M wave in 14 of 92 patients. Three of these 14 patients tested positive for the muscle-specific tyrosine kinase antibody (MuSK-Ab), and 11 patients tested positive for the acetylcholine receptor antibody (AchR-Ab). The characteristics of the afterdischarges on RNS differed distinctly between the two antibody groups. The afterdischarges occurred on the first stimulation, but decreased on the second and subsequent stimulations in patients with MuSK-MG, while the afterdischarges continued to occur on each stimulation in patients with AchR-MG.<\/jats:p><jats:p><jats:bold>Discussion:<\/jats:bold> The characteristics of the afterdischarges on RNS enabled easy identification of their synaptic or neurogenic nature.<\/jats:p>","DOI":"10.3389\/fneur.2021.599744","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T04:30:21Z","timestamp":1618288221000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Afterdischarges in Myasthenia Gravis"],"prefix":"10.3389","volume":"12","author":[{"given":"Li","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shougang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,4,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.nmd.2006.07.002","article-title":"Isaacs' syndrome associated with myasthenia gravis, showing remission after cytoreductive surgery of pleural recurrence of thymoma","volume":"16","author":"Fukushima","year":"2006","journal-title":"Neuromuscul Disord"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1212\/WNL.50.5.1483","article-title":"Antibodies to ion-channel proteins in thymoma with myasthenia, neuromyotonia, and peripheral neuropathy","volume":"50","author":"Heidenreich","year":"1998","journal-title":"Neurology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1212\/WNL.53.6.1233","article-title":"Myasthenia, thymoma, presynaptic antibodies, and a continuum of neuromuscular hyperexcitability","volume":"53","author":"Vernino","year":"1999","journal-title":"Neurology"},{"key":"B4","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1212\/WNL.0b013e3182061b1e","article-title":"Peripheral nerve hyperexcitability: a clinical and immunologic study of 38 patients","volume":"76","author":"Rubio-Agusti","year":"2011","journal-title":"Neurology"},{"key":"B5","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3988\/jcn.2014.10.1.69","article-title":"Myasthenia in acquired neuromyotonia","volume":"10","author":"Byun","year":"2014","journal-title":"J Clin Neurol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1111\/j.1085-9489.2004.09207.x","article-title":"Unusual neurophysiological and immunological findings in myasthenia gravis: a case report","volume":"9","author":"Scaioli","year":"2004","journal-title":"J Peripher Nerv Syst."},{"key":"B7","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1002\/mus.20774","article-title":"Accuracy of repetitive nerve stimulation for diagnosis of the cramp-fasciculation syndrome","volume":"35","author":"Harrison","year":"2007","journal-title":"Muscle Nerve"},{"key":"B8","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1097\/WNF.0000000000000432","article-title":"Muscle-specific tyrosine kinase antibody positive myasthenia gravis with peripheral nerve hyperexcitability: case report and literature review","volume":"44","author":"Yang","year":"2021","journal-title":"Clin Neuropharmacol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.cnp.2017.02.002","article-title":"Afterdischarges following M waves in patients with voltage-gated potassium channels antibodies","volume":"2","author":"Niu","year":"2017","journal-title":"Clin Neurophysiol Pract"},{"key":"B10","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1055\/s-0038-1676514","article-title":"Muscle-specific kinase autoimmune myasthenia gravis: report of a pediatric case and literature review","volume":"50","author":"Ben Younes","year":"2019","journal-title":"Neuropediatrics"},{"key":"B11","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1002\/mus.20935","article-title":"Electrophysiological signs and the prevalence of adverse effects of acetylcholinesterase inhibitors in patients with myasthenia gravis","volume":"37","author":"Punga","year":"2008","journal-title":"Muscle Nerve"},{"key":"B12","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.jns.2011.12.016","article-title":"Neurophysiological characteristics of MuSK antibody positive myasthenia gravis mice: focal denervation and hypersensitivity to acetylcholinesterase inhibitors","volume":"316","author":"Chroni","year":"2012","journal-title":"J Neurol Sci"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1212\/WNL.0b013e3182377fa6","article-title":"Myasthenia gravis with antibodies to MuSK. 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