{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:40:06Z","timestamp":1790617206492,"version":"4.1.0"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T00:00:00Z","timestamp":1618272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> To report a case series of dysautonomia associated with COVID-19 infection.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> This is a retrospective review of patients evaluated in the autonomic clinic at our institution with suspected signs and symptoms of dysautonomia who underwent formal evaluation, including autonomic testing.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Six patients were identified with signs and symptoms suggestive of dysautonomia who underwent autonomic testing. All patients had symptoms typical of COVID-19 infection, though none were hospitalized for these or other symptoms. All patients reported symptoms of postural lightheadedness and near-syncope, fatigue, and activity intolerance. Five patients reported the onset of autonomic symptoms concomitant with other COVID-19 symptoms, with the other patient reporting symptom onset 6 weeks following initial COVID-19 symptoms. Autonomic testing demonstrated an excessive postural tachycardia in 4 patients, a hypertensive response with head-up tilt in 3 patients, orthostatic hypotension in 1 patient, and sudomotor impairment in 1 of the patients with excessive postural tachycardia.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> We present clinical features and results of autonomic testing in 6 patients with a history COVID-19 infection. While all patients reported typical features of orthostatic intolerance, fatigue, and activity intolerance, the results of autonomic testing were heterogenous, with orthostatic hypotension in 1 patient, excessive postural tachycardia typical of postural tachycardia syndrome in 4 patients, and postural hypertension in 3 patients.<\/jats:p>","DOI":"10.3389\/fneur.2021.624968","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T06:21:29Z","timestamp":1618294889000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":81,"title":["COVID-19 Dysautonomia"],"prefix":"10.3389","volume":"12","author":[{"given":"Brent P.","family":"Goodman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Khoury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janis E.","family":"Blair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie F.","family":"Grill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,4,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e1060","DOI":"10.1212\/WNL.0000000000009937","article-title":"Neurologic manifestations in hospitalized patients with COVID-19: The ALBACOVID registry","volume":"95","author":"Romero-S\u00e1nchez","year":"2020","journal-title":"Neurology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/S1474-4422(20)30221-0","article-title":"Neurological associations of COVID-19","volume":"19","author":"Ellul","year":"2020","journal-title":"Lancet Neurol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1001\/jamaneurol.2020.1127","article-title":"Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China","volume":"77","author":"Mao","year":"2020","journal-title":"JAMA Neurol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1017\/S0317167100004108","article-title":"Autonomic dysfunction in recovered severe acute respiratory syndrome patients","volume":"32","author":"Loa","year":"2020","journal-title":"Can J Neurol Sci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.autneu.2018.04.004","article-title":"Evaluation of postural tachycardia syndrome (POTS)","volume":"215","author":"Goodman","year":"2018","journal-title":"Auton Neurosci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1002\/ana.410140513","article-title":"Quantitative sudomotor axon reflex testing in normal and neuropathic subjects","volume":"14","author":"Low","year":"1983","journal-title":"Ann Neurol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3988\/jcn.2013.9.1.1","article-title":"Autonomic function tests: some clinical applications","volume":"9","author":"Low","year":"2013","journal-title":"J Clin Neurol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10286-020-00727-9","article-title":"A case report of postural tachycardia syndrome after COVID-19","volume":"3","author":"Miglis","year":"2020","journal-title":"Clin Auton Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2490","DOI":"10.1007\/s00415-020-09904-2","article-title":"Non-epileptic seizures in autonomic dysfunction as the initial symptom of COVID-19","volume":"267","author":"Logmin","year":"2020","journal-title":"J. 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