{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:30:22Z","timestamp":1784302222789,"version":"3.55.0"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T00:00:00Z","timestamp":1612396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) are clinical syndromes classified as atypical parkinsonism. Due to their overlapping symptomatology, recent research shows the necessity of finding new methods of examination of these clinical entities. PSP is a heterogenic disease. PSP Richardson-Steele Syndrome (PSP-RS) and parkinsonism predominant (PSP-P) are the most common clinical variants of progressive supranuclear palsy syndrome. The different clinical course and life expectancy of PSP-RS and PSP-P stress the need of efficient examination in the early stages. The aim of the study was to evaluate the possible feasibility of the combined use of frontal assessment battery (FAB) and single-photon emission computed tomography (SPECT) in the differentiation of PSP-RS, PSP-P, and CBS. The findings show that FAB may be interpreted as a possible supplementary tool in the differential diagnosis of PSP-P and PSP-RS. The differences in SPECT are less pronounced. The study does not show any advantages of performing combined frontal SPECT and FAB in the differential examination of PSP and CBS. Moreover, PSP-RS and CBS, in a detailed evaluation of the frontal lobe, do not show any significant differences. This is a relatively small study which, however, highlights the relevant features of clinical examination of these rare entities.<\/jats:p>","DOI":"10.3389\/fneur.2021.630153","type":"journal-article","created":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T15:50:29Z","timestamp":1612453829000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["The Role of Frontal Assessment Battery and Frontal Lobe Single-Photon Emission Computed Tomography in the Differential Diagnosis of Progressive Supranuclear Palsy Variants and Corticobasal Syndrome\u2014A Pilot Study"],"prefix":"10.3389","volume":"12","author":[{"given":"Piotr","family":"Alster","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartosz","family":"Migda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Madetko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Duszy\u0144ska-W\u0105s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Drzewi\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingeborga","family":"Charzy\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi\u0142osz","family":"Starczy\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ada","family":"Szepelska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leszek","family":"Kr\u00f3licki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,2,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1002\/mds.27872","article-title":"Movement disorder society-endorsed progressive supranuclear palsy study group. validation of the movement disorder society criteria for the diagnosis of 4-repeat tauopathies","volume":"35","author":"Respondek","year":"2020","journal-title":"Mov Disord."},{"key":"B2","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1002\/mds.26987","article-title":"Clinical diagnosis of progressive supranuclear palsy: the movement disorder society criteria","volume":"32","author":"H\u00f6glinger","year":"2017","journal-title":"Mov Disord."},{"key":"B3","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1212\/WNL.0b013e31827f0fd1","article-title":"Criteria for the diagnosis of corticobasal degeneration","volume":"80","author":"Armstrong","year":"2013","journal-title":"Neurology"},{"key":"B4","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.pjnns.2015.10.002","article-title":"The role of neuroimaging in the diagnosis of the atypical parkinsonian syndromes in clinical practice","volume":"49","author":"Dabrowska","year":"2015","journal-title":"Neurol Neurochir Pol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1002\/mds.23295","article-title":"Cortical atrophy differentiates Richardson's syndrome from the parkinsonian form of progressive supranuclear palsy","volume":"26","author":"Schofield","year":"2011","journal-title":"Mov Disord"},{"key":"B6","doi-asserted-by":"publisher","first-page":"e16603","DOI":"10.1097\/MD.0000000000016603","article-title":"Thalamic and cerebellar hypoperfusion in single photon emission computed tomography may differentiate multiple system atrophy and progressive supranuclear palsy","volume":"98","author":"Alster","year":"2019","journal-title":"Medicine"},{"key":"B7","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.jocn.2020.05.005","article-title":"Is brain perfusion a differentiating feature in the comparison of Progressive Supranuclear Palsy Syndrome (PSPS) and Corticobasal Syndrome (CBS)?","volume":"77","author":"Alster","year":"2020","journal-title":"J Clin Neurosci."},{"key":"B8","first-page":"384","article-title":"Dual-tracer dopamine transporter and perfusion SPECT in differential diagnosis of parkinsonism using template-based discriminant analysis","volume":"47","author":"Van Laere","year":"2006","journal-title":"J Nucl Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1093\/brain\/120.12.2187","article-title":"Complementary PET studies of striatal neuronal function in the differential diagnosis between multiple system atrophy and Parkinson's disease","volume":"120","author":"Antonini","year":"1997","journal-title":"Brain"},{"key":"B10","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s00259-002-1009-9","article-title":"Anatomically standardised 99mTc-ECD brain perfusion SPET allows accurate differentiation between healthy volunteers, multiple system atrophy and idiopathic Parkinson's disease","volume":"30","author":"Bosman","year":"2003","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1002\/mds.10270","article-title":"Tc-99m ethylene cysteinate dimer SPECT in the differential diagnosis of parkinsonism","volume":"17","author":"Feigin","year":"2002","journal-title":"Mov Disord"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1212\/WNL.55.11.1621","article-title":"The FAB. A frontal assessment battery at bedside","volume":"55","author":"Dubois","year":"2000","journal-title":"Neurology"},{"key":"B13","first-page":"21","article-title":"Diagnostyka neuropsychologiczna w atypowych zespo\u0142ach parkinsonowskich","volume":"11","author":"Sitek","year":"2015","journal-title":"Pol Przeg Neurol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1177\/0891988712445087","article-title":"The frontal assessment battery as a tool for evaluation of frontal lobe dysfunction in patients with parkinson disease","volume":"25","author":"Cohen","year":"2012","journal-title":"J Geriatr Psychiatr Neurol."},{"key":"B15","first-page":"71","article-title":"Zaburzenia poznawcze i emocjonalne\u201d in Choroba Parkinsona","author":"Drzewi\u0144ska","year":"2019"},{"key":"B16","doi-asserted-by":"publisher","first-page":"180","DOI":"10.3389\/fneur.2020.00180","article-title":"Progressive supranuclear palsy-parkinsonism predominant (PSP-P)-a clinical challenge at the boundaries of PSP and Parkinson's Disease (PD)","volume":"11","author":"Alster","year":"2020","journal-title":"Front Neurol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"101","DOI":"10.3389\/fneur.2019.00101","article-title":"Accumulation of tau protein, metabolism and perfusion-application and efficacy of positron emission tomography (PET) and single photon emission computed tomography (SPECT) Imaging in the examination of progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS)","volume":"10","author":"Alster","year":"2019","journal-title":"Front Neurol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s00259-005-1920-y","article-title":"Quantitative simultaneous (99m)Tc-ECD\/123I-FP-CIT SPECT in Parkinson's disease and multiple system atrophy","volume":"33","author":"El Fakhri","year":"2006","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"B19","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.parkreldis.2017.10.002","article-title":"Neuropsychiatric and cognitive profile of early Richardson's syndrome, Progressive Supranuclear Palsy-parkinsonism and Parkinson's disease","volume":"45","author":"Pellicano","year":"2017","journal-title":"Parkinson Related Disord."},{"key":"B20","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.parkreldis.2019.07.010","article-title":"Progression of two progressive supranuclear palsy phenotypes with comparable initial disability","volume":"66","author":"Shoeibi","year":"2019","journal-title":"Parkinsonism Relat Disord."},{"key":"B21","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1097\/MNM.0b013e32833e5f90","article-title":"Preliminary studies of differential impairments of the dopaminergic system in subtypes of progressive supranuclear palsy","volume":"31","author":"Lin","year":"2010","journal-title":"Nucl Med Commun."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2214\/AJR.19.22436","article-title":"Diagnostic performance of 123I-FPCIT SPECT specific binding ratio in progressive supranuclear palsy: use of core clinical features and MRI for comparison","volume":"6","author":"Sakamoto","year":"2020","journal-title":"AJR Am J Roentgenol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"116627","DOI":"10.1016\/j.jns.2019.116627","article-title":"Differences in cerebellar perfusion between Parkinson's disease and multiple system atrophy","volume":"409","author":"Murakami","year":"2020","journal-title":"J Neurol Sci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"15761","DOI":"10.1038\/s41598-020-72321-y","article-title":"Laterality of specific binding ratios on DAT-SPECT for differential diagnosis of degenerative parkinsonian syndromes","volume":"10","author":"Shigekiyo","year":"2020","journal-title":"Sci Rep."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2603","DOI":"10.1007\/s00415-020-09883-4","article-title":"Ioflupane 123I (DAT scan) SPECT identifies dopamine receptor dysfunction early in the disease course in progressive apraxia of speech","volume":"267","author":"Seckin","year":"2020","journal-title":"J Neurol."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2021.630153\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T15:50:32Z","timestamp":1612453832000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2021.630153\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,4]]},"references-count":25,"alternative-id":["10.3389\/fneur.2021.630153"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2021.630153","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,4]]},"article-number":"630153"}}