{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:20:17Z","timestamp":1790259617227,"version":"4.1.0"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T00:00:00Z","timestamp":1617148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>Guillain-Barr\u00e9 syndrome (GBS) is an acute inflammatory polyradiculoneuropathy in which most patients have cranial nerve involvement, with facial nerve involvement being the most common. However, delayed facial palsy (DFP) with asymmetric facial palsy is a rare manifestation of GBS, and the mechanism is unclear. We report a case of GBS combined with delayed unilateral facial palsy and review previously reported cases of GBS combined with DFP. A total of 28 cases of GBS with DFP, including the case in this report, were included in this study. The occurrence of DFP may be related to early subclinical demyelination of the facial nerve, the blood-nerve barrier of the facial nerve, facial movement, and descending reversible paralysis. The occurrence of unilateral facial palsy may be related to <jats:italic>Campylobacter jejuni<\/jats:italic>, specific anti-ganglioside antibodies, and the site of central nervous system anatomical involvement. There is no evidence that immunotherapy is related to the shortening of DFP course and improving patients' prognosis.<\/jats:p>","DOI":"10.3389\/fneur.2021.658266","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T05:10:28Z","timestamp":1617167428000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Case Report and Literature Analysis: Guillain-Barr\u00e9 Syndrome With Delayed Unilateral Facial Palsy"],"prefix":"10.3389","volume":"12","author":[{"given":"Xuanyu","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajing","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiping","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,3,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"S43","DOI":"10.4103\/0976-3147.145200","article-title":"A study of Guillain-Barr\u00e9 syndrome with reference to cranial neuropathy and its prognostic implication","volume":"5","author":"Bhargava","year":"2014","journal-title":"J Neurosci Rural Pract."},{"key":"B2","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1056\/NEJM199204233261706","article-title":"The Guillain-Barr\u00e9 syndrome","volume":"326","author":"Ropper","year":"1992","journal-title":"N Engl J Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1002\/mus.24475","article-title":"Delayed facial weakness in Guillain-Barr\u00e9 and Miller Fisher syndromes","volume":"51","author":"Tatsumoto","year":"2015","journal-title":"Muscle Nerve."},{"key":"B4","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1056\/NEJM195607122550201","article-title":"An unusual variant of acute idiopathic polyneuritis (syndrome of ophthalmoplegia, ataxia and areflexia)","volume":"255","author":"Fisher","year":"1956","journal-title":"N Engl J Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1136\/jnnp.64.3.399","article-title":"Development of facial palsy during immunoadsorption plasmapheresis in Miller Fisher syndrome: a clinical report of two cases","volume":"64","author":"Chida","year":"1998","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"B6","doi-asserted-by":"publisher","first-page":"300060519867490","DOI":"10.1177\/0300060519867490","article-title":"Miller Fisher syndrome with early intracranial hypertension and delayed bilateral simultaneous facial nerve palsy: a case report","volume":"48","author":"Liu","year":"2020","journal-title":"J Int Med Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.jns.2015.08.009","article-title":"Delayed facial palsy in Miller Fisher syndrome","volume":"358","author":"Tan","year":"2015","journal-title":"J Neurol Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"234","DOI":"10.5692\/clinicalneurol.cn-000968","article-title":"[Serial neurophysiological and neurophysiological examinations for delayed facial nerve palsy in a patient with Fisher syndrome]. 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