{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T07:35:33Z","timestamp":1769758533666,"version":"3.49.0"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>Despite extensive evidence of benefit of thrombectomy in adult ischemic stroke due to large-vessel occlusion in the 6-h window, its role remains uncertain in very young children. We describe hereafter the case of a 2-year-old female child who had a successful thrombectomy 9 h after stroke onset. The patient presented with right hemiplegia, central facial palsy, a normal level of consciousness, and speech difficulties. The PedNIHS score was 11. CT scan without contrast injection displayed spontaneous hyperdensity of the middle cerebral artery (MCA), with only limited early signs of ischemia (ASPECTS 8). CT angiography demonstrated occlusion of the proximal MCA with good collaterals. Thrombectomy was realized. Complete recanalization (TICI 3) was obtained under general anesthesia after two passes of a stent retriever. Time from symptoms onset to full recanalization was 9 h. The acute ischemic stroke was caused by embolic thrombus from a congenital heart disease. Clinical recovery was complete. Three months after the thrombectomy, the young patient was doing well without any neurological sequelae (PedNIHSS 0; modified Rankin Scale: 0). This case report is an example of a decision-making process to perform thrombectomy in a very young child, which included cardio-embolic etiology as a parameter that potentially might have participated to the successful outcome of the therapeutic procedure.<\/jats:p>","DOI":"10.3389\/fneur.2021.670565","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T07:41:54Z","timestamp":1622187714000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Case Report: Late Successful Thrombectomy for Ischemic Stroke in a 2-Year-Old Child"],"prefix":"10.3389","volume":"12","author":[{"given":"Nathalie","family":"Nasr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Delamarre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Cheuret","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Chausseray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Marc","family":"Olivot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Acar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrice","family":"Bonneville","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,5,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.pediatrneurol.2016.09.007","article-title":"Thrombectomy for acute stroke in childhood: a case report, literature review, and recommendations","volume":"66","author":"Buompadre","year":"2017","journal-title":"Pediatr Neurol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1136\/neurintsurg-2016-012320","article-title":"Mechanical thrombectomy for pediatric acute ischemic stroke: review of the literature","volume":"9","author":"Satti","year":"2017","journal-title":"J Neurointerv Surg."},{"key":"B3","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1001\/jamaneurol.2019.3403","article-title":"Feasibility, safety, and outcome of endovascular recanalization in childhood stroke: the save ChildS Study","volume":"77","author":"Sporns","year":"2020","journal-title":"JAMA Neurol."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706442","article-title":"Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct","author":"Nogueira","year":"2018","journal-title":"N Engl J Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1056\/NEJMoa1713973","article-title":"Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging","volume":"378","author":"Albers","year":"2018","journal-title":"N Engl J Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"e343","DOI":"10.1212\/WNL.0000000000011107","article-title":"Clinical diffusion mismatch to select pediatric patients for embolectomy 6 to 24 hours after stroke: an analysis of the Save ChildS Study","volume":"96","author":"Sporns","year":"2021","journal-title":"Neurology."},{"key":"B7","doi-asserted-by":"publisher","first-page":"S158","DOI":"10.1212\/WNL.0b013e31826958bf","article-title":"Endovascular therapy in children with acute ischemic stroke: review and recommendations","volume":"79","author":"Ellis","year":"2012","journal-title":"Neurology."},{"key":"B8","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1002\/ana.22427","article-title":"Acute ischemic stroke in children versus young adults","volume":"70","author":"Bigi","year":"2011","journal-title":"Ann Neurol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1016\/S1474-4422(09)70241-8","article-title":"International Pediatric Stroke Study Group. 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