{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T23:13:12Z","timestamp":1782515592894,"version":"3.54.5"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:00:00Z","timestamp":1628121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Parkinson's disease (PD) is a progressive neurodegenerative disease with motor- and non-motor symptoms. When the disease progresses, symptom burden increases. Consequently, additional care demands develop, the complexity of treatment increases, and the patient's quality of life is progressively threatened. To address these challenges, there is growing awareness of the potential benefits of palliative care for people with PD. This includes communication about end-of-life issues, such as Advance Care Planning (ACP), which helps to elicit patient's needs and preferences on issues related to future treatment and care. In this study, we will assess the impact and feasibility of a nurse-led palliative care intervention for people with PD across diverse European care settings.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The intervention will be evaluated in a multicentre, open-label randomized controlled trial, with a parallel group design in seven European countries (Austria, Estonia, Germany, Greece, Italy, Sweden and United Kingdom). The \u201cPD_Pal intervention\u201d comprises (1) several consultations with a trained nurse who will perform ACP conversations and support care coordination and (2) use of a patient-directed \u201cParkinson Support Plan-workbook\u201d. The primary endpoint is defined as the percentage of participants with documented ACP-decisions assessed at 6 months after baseline (t1). Secondary endpoints include patients' and family caregivers' quality of life, perceived care coordination, patients' symptom burden, and cost-effectiveness. In parallel, we will perform a process evaluation, to understand the feasibility of the intervention. Assessments are scheduled at baseline (t0), 6 months (t1), and 12 months (t2). Statistical analysis will be performed by means of Mantel\u2013Haenszel methods and multilevel logistic regression models, correcting for multiple testing.<\/jats:p><jats:p><jats:bold>Discussion:<\/jats:bold> This study will contribute to the current knowledge gap on the application of palliative care interventions for people with Parkinson's disease aimed at ameliorating quality of life and managing end-of-life perspectives. Studying the impact and feasibility of the intervention in seven European countries, each with their own cultural and organisational characteristics, will allow us to create a broad perspective on palliative care interventions for people with Parkinson's disease across settings.<\/jats:p><jats:p><jats:bold>Clinical Trial Registration:<\/jats:bold><jats:ext-link>www.trialregister.nl<\/jats:ext-link>, NL8180.<\/jats:p>","DOI":"10.3389\/fneur.2021.673893","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T06:16:22Z","timestamp":1628144182000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Advance Care Planning and Care Coordination for People With Parkinson's Disease and Their Family Caregivers\u2014Study Protocol for a Multicentre, Randomized Controlled Trial"],"prefix":"10.3389","volume":"12","author":[{"given":"Marjan J.","family":"Meinders","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Gentile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anette E.","family":"Schrag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spiros","family":"Konitsiotis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Eggers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pille","family":"Taba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Lorenzl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Odin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Rosqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Ray","family":"Chaudhuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Antonini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastiaan R.","family":"Bloem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke M.","family":"Groot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,8,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1001\/jamaneurol.2017.3299","article-title":"The Parkinson pandemic-a call to action","volume":"75","author":"Dorsey","year":"2018","journal-title":"JAMA Neurol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1007\/s00415-010-5566-8","article-title":"Late-stage Parkinson's disease: the Barcelona and Lisbon cohort","volume":"257","author":"Coelho","year":"2010","journal-title":"J Neurol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1111\/ene.12567","article-title":"Dementia and severity of parkinsonism determines the handicap of patients in late-stage Parkinson's disease: the Barcelona-Lisbon cohort","volume":"22","author":"Coelho","year":"2015","journal-title":"Eur J Neurol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1111\/jnc.13691","article-title":"The clinical symptoms of Parkinson's disease","volume":"139","author":"Sveinbjornsdottir","year":"2016","journal-title":"J Neurochem."},{"key":"B5","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.parkreldis.2020.05.016","article-title":"The late stage of Parkinson's -results of a large multinational study on motor and non-motor complications","volume":"75","author":"Schrag","year":"2020","journal-title":"Parkinsonism Relat Disord."},{"key":"B6","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1002\/mdc3.12968","article-title":"The prevalence and determinants of neuropsychiatric symptoms in late-stage Parkinsonism","volume":"7","author":"Hommel","year":"2020","journal-title":"Mov Disord Clin Pract."},{"key":"B7","doi-asserted-by":"publisher","first-page":"e46327","DOI":"10.1371\/journal.pone.0046327","article-title":"Symptoms and quality of life in late stage Parkinson syndromes: a longitudinal community study of predictive factors","volume":"7","author":"Higginson","year":"2012","journal-title":"PLoS ONE."},{"key":"B8","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.parkreldis.2006.11.009","article-title":"Measuring symptom load in Idiopathic Parkinson's disease","volume":"13","author":"Lee","year":"2007","journal-title":"Parkinsonism Relat Disord."},{"key":"B9","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1177\/0269216308100773","article-title":"Palliative stage Parkinson's disease: patient and family experiences of health-care services","volume":"23","author":"Giles","year":"2009","journal-title":"Palliat Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1177\/0269216310371414","article-title":"An exploration into the palliative and end-of-life experiences of carers of people with Parkinson's disease","volume":"24","author":"Hasson","year":"2010","journal-title":"Palliat Med."},{"key":"B11","doi-asserted-by":"publisher","first-page":"120","DOI":"10.3389\/fneur.2018.00120","article-title":"Impaired quality of life and need for palliative care in a german cohort of advanced parkinson's disease patients","volume":"9","author":"Klietz","year":"2018","journal-title":"Front Neurol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1177\/0269216313490436","article-title":"Place of death, and its relation with underlying cause of death, in Parkinson's disease, motor neurone disease, and multiple sclerosis: a population-based study","volume":"27","author":"Sleeman","year":"2013","journal-title":"Palliat Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1001\/jamaneurol.2019.4697","article-title":"Palliative programs for persons with parkinsonism-the next frontier","volume":"77","author":"Bloem","year":"2020","journal-title":"JAMA Neurol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1007\/s13311-020-00989-1","article-title":"Palliative care for Parkinson's spectrum disorders: an emerging approach","volume":"17","author":"Katz","year":"2020","journal-title":"Neurotherapeutics."},{"key":"B15","unstructured":"WHO Definition of palliative care2012"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e543","DOI":"10.1016\/S1470-2045(17)30582-X","article-title":"Definition and recommendations for advance care planning: an international consensus supported by the European Association for Palliative Care","volume":"18","author":"Rietjens","year":"2017","journal-title":"Lancet Oncol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.1200\/JCO.2010.32.4459","article-title":"Longitudinal perceptions of prognosis and goals of therapy in patients with metastatic non-small-cell lung cancer: results of a randomized study of early palliative care","volume":"29","author":"Temel","year":"2011","journal-title":"J Clin Oncol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1016\/S0140-6736(13)62416-2","article-title":"Early palliative care for patients with advanced cancer: a cluster-randomised controlled trial","volume":"383","author":"Zimmermann","year":"2014","journal-title":"Lancet."},{"key":"B19","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1200\/JCO.2016.70.1474","article-title":"Integration of palliative care into standard oncology care: american society of clinical oncology clinical practice guideline update","volume":"35","author":"Ferrell","year":"2017","journal-title":"J Clin Oncol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1178224218813914","DOI":"10.1177\/1178224218813914","article-title":"Palliative care in motor neurone disease: where are we now?","volume":"12","author":"Oliver","year":"2019","journal-title":"Palliat Care."},{"key":"B21","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s11910-015-0542-4","article-title":"Palliative care for Parkinson's disease: has the time come?","volume":"15","author":"Miyasaki","year":"2015","journal-title":"Curr Neurol Neurosci Rep."},{"key":"B22","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1212\/WNL.0000000000000674","article-title":"Palliative care and neurology: time for a paradigm shift","volume":"83","author":"Boersma","year":"2014","journal-title":"Neurology."},{"key":"B23","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.parkreldis.2019.04.014","article-title":"Barriers to reporting non-motor symptoms to health-care providers in people with Parkinson's","volume":"64","author":"Hurt","year":"2019","journal-title":"Parkinsonism Relat Disord."},{"key":"B24","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1001\/jamaneurol.2019.4992","article-title":"Comparison of integrated outpatient palliative care with standard care in patients with parkinson disease and related disorders: a randomized clinical trial","volume":"77","author":"Kluger","year":"2020","journal-title":"JAMA Neurol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s12904-019-0441-6","article-title":"Palliative care for persons with Parkinson's disease: a qualitative study on the experiences of health care professionals","volume":"18","author":"Lennaerts","year":"2019","journal-title":"BMC Palliat Care."},{"key":"B26","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1089\/jpm.2016.0325","article-title":"Palliative Care and Parkinson's Disease: Caregiver Perspectives","volume":"20","author":"Boersma","year":"2017","journal-title":"J Palliat Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.parkreldis.2017.01.008","article-title":"Palliative care and Parkinson's disease: Meeting summary and recommendations for clinical research","volume":"37","author":"Kluger","year":"2017","journal-title":"Parkinsonism Relat Disord."},{"key":"B28","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1002\/mdc3.12702","article-title":"Defining palliative care needs in Parkinson's disease","volume":"6","author":"Kluger","year":"2019","journal-title":"Mov Disord Clin Pract."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1111\/ene.14424","article-title":"Experiences of advance care planning in Parkinson's disease and atypical parkinsonian disorders: a mixed methods systematic review","volume":"27","author":"Nimmons","year":"2020","journal-title":"Eur J Neurol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1177\/0269216313495287","article-title":"Palliative care for Parkinson's disease: a summary of the evidence and future directions","volume":"27","author":"Richfield","year":"2013","journal-title":"Palliat Med."},{"key":"B31","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1177\/1742395309102819","article-title":"Palliative care and Parkinson's disease: managing the chronic-palliative interface","volume":"5","author":"Lanoix","year":"2009","journal-title":"Chron Illn."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1007\/s00415-011-5972-6","article-title":"How well do we recognise non-motor symptoms in a British Parkinson's disease population?","volume":"258","author":"Hu","year":"2011","journal-title":"J Neurol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson's disease","volume":"30","author":"Postuma","year":"2015","journal-title":"Mov Disord."},{"key":"B34","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1007\/s00702-017-1700-4","article-title":"Differentiation of atypical Parkinson syndromes","volume":"124","author":"H\u00f6glinger","year":"2017","journal-title":"J Neural Transm."},{"key":"B35","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1212\/WNL.17.5.427","article-title":"Parkinsonism: onset, progression and mortality","volume":"17","author":"Hoehn","year":"1967","journal-title":"Neurology."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.3233\/JPD-191884","article-title":"How long can I carry on? The need for palliative care in parkinson's disease: a qualitative study from the perspective of bereaved family caregivers","volume":"10","author":"Lennaerts-Kats","year":"2020","journal-title":"J Parkinsons Dis."},{"key":"B37","doi-asserted-by":"publisher","first-page":"e0230611","DOI":"10.1371\/journal.pone.0230611","article-title":"RADPAC-PD: A tool to support healthcare professionals in timely identifying palliative care needs of people with Parkinson's disease","volume":"15","author":"Lennaerts-Kats","year":"2020","journal-title":"PLoS ONE."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1016\/j.pec.2015.06.022","article-title":"Shared decision making: concepts, evidence, and practice","volume":"98","author":"Stiggelbout","year":"2015","journal-title":"Patient Educ Couns."},{"key":"B39","doi-asserted-by":"publisher","first-page":"511","DOI":"10.2307\/3350391","article-title":"Organizing care for patients with chronic illness","volume":"74","author":"Wagner","year":"1996","journal-title":"Milbank Q."},{"key":"B40","doi-asserted-by":"publisher","first-page":"c1345","DOI":"10.1136\/bmj.c1345","article-title":"The impact of advance care planning on end of life care in elderly patients: randomised controlled trial","volume":"340","author":"Detering","year":"2010","journal-title":"BMJ."},{"key":"B41","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.jamda.2018.09.014","article-title":"Interventions guiding advance care planning conversations: a systematic review","volume":"20","author":"Fahner","year":"2019","journal-title":"J Am Med Dir Assoc."},{"key":"B42","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1186\/s12885-016-2298-x","article-title":"Advance care planning\u2013a multi-centre cluster randomised clinical trial: the research protocol of the ACTION study","volume":"16","author":"Rietjens","year":"2016","journal-title":"BMC Cancer."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1001\/jamainternmed.2018.4657","article-title":"Engaging diverse english- and spanish-speaking older adults in advance care planning: the PREPARE randomized clinical trial","volume":"178","author":"Sudore","year":"2018","journal-title":"JAMA Intern Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1186\/s12883-018-1184-3","article-title":"Study protocol: care of late-stage parkinsonism (CLaSP): a longitudinal cohort study","volume":"18","author":"Balzer-Geldsetzer","year":"2018","journal-title":"BMC Neurol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"4156","DOI":"10.1109\/EMBC44109.2020.9175913","article-title":"On-Body Sensor Position Identification with a Simple, Robust and Accurate Method, Validated in Patients with Parkinson's Disease","volume":"2020","author":"Kostikis","year":"2020","journal-title":"Annu Int Conf IEEE Eng Med Biol Soc."},{"key":"B46","doi-asserted-by":"publisher","first-page":"21329","DOI":"10.3390\/s141121329","article-title":"PERFORM: a system for monitoring, assessment and management of patients with Parkinson's disease","volume":"14","author":"Tzallas","year":"2014","journal-title":"Sensors."},{"key":"B47","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1002\/mds.22340","article-title":"Movement disorder society-sponsored revision of the unified parkinson's disease rating scale (MDS-UPDRS): scale presentation and clinimetric testing results","volume":"23","author":"Goetz","year":"2008","journal-title":"Mov Disord."},{"key":"B48","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1002\/mdc3.12728","article-title":"Pilot study of the international parkinson and movement disorder society-sponsored non-motor rating scale (MDS-NMS)","volume":"6","author":"Martinez-Martin","year":"2019","journal-title":"Mov Disord Clin Pract."},{"key":"B49","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J Am Geriatr Soc."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1016\/j.jclinepi.2008.01.006","article-title":"The Charlson comorbidity index is adapted to predict costs of chronic disease in primary care patients","volume":"61","author":"Charlson","year":"2008","journal-title":"J Clin Epidemiol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"e949","DOI":"10.3399\/bjgp12X652364","article-title":"Measuring continuity of care: psychometric properties of the Nijmegen Continuity Questionnaire","volume":"62","author":"Uijen","year":"2012","journal-title":"Br J Gen Pract."},{"key":"B52","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1007\/s12603-010-0316-2","article-title":"The Resource Utilization in Dementia (RUD) instrument is valid for assessing informal care time in community-living patients with dementia","volume":"14","author":"Wimo","year":"2010","journal-title":"J Nutr Health Aging."},{"key":"B53","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jpainsymman.2009.05.012","article-title":"The Quality of Dying and Death Questionnaire (QODD): empirical domains and theoretical perspectives","volume":"39","author":"Downey","year":"2010","journal-title":"J Pain Symptom Manage."},{"key":"B54","doi-asserted-by":"publisher","first-page":"S6","DOI":"10.1016\/j.parkreldis.2012.06.013","article-title":"Palliative care for advanced Parkinson disease: an interdisciplinary clinic and new scale, the ESAS-PD","volume":"18","author":"Miyasaki","year":"2012","journal-title":"Parkinsonism Relat Disord."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1136\/jnnp.51.11.1401","article-title":"Parkinson's disease and depression: psychometric properties of the Beck Depression Inventory","volume":"51","author":"Levin","year":"1988","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"B56","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/BF02260863","article-title":"The development and validation of a short measure of functioning and well being for individuals with Parkinson's disease","volume":"4","author":"Peto","year":"1995","journal-title":"Qual Life Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1007\/s11136-011-9903-x","article-title":"Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L)","volume":"20","author":"Herdman","year":"2011","journal-title":"Qual Life Res."},{"key":"B58","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1177\/0269216315608348","article-title":"Discovering the hidden benefits of cognitive interviewing in two languages: The first phase of a validation study of the Integrated Palliative care Outcome Scale","volume":"30","author":"Schildmann","year":"2016","journal-title":"Palliat Med."},{"key":"B59","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.jclinepi.2013.12.010","article-title":"Measuring patient satisfaction with health care treatment using the Short Assessment of Patient Satisfaction measure delivered superior and robust satisfaction estimates","volume":"67","author":"Hawthorne","year":"2014","journal-title":"J Clin Epidemiol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.pec.2013.05.009","article-title":"Developing CollaboRATE: a fast and frugal patient-reported measure of shared decision making in clinical encounters","volume":"93","author":"Elwyn","year":"2013","journal-title":"Patient Educ Couns."},{"key":"B61","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s11136-015-1071-y","article-title":"Development and validation of a carers quality-of-life questionnaire for parkinsonism (PQoL Carers)","volume":"25","author":"Pillas","year":"2016","journal-title":"Qual Life Res."},{"key":"B62","doi-asserted-by":"publisher","first-page":"e0226916","DOI":"10.1371\/journal.pone.0226916","article-title":"Experiences of health services and unmet care needs of people with late-stage Parkinson's in England: A qualitative study","volume":"14","author":"Read","year":"2019","journal-title":"PLoS ONE."},{"key":"B63","doi-asserted-by":"publisher","first-page":"i22","DOI":"10.1136\/bmjqs-2012-001197","article-title":"Conducting a multicentre and multinational qualitative study on patient transitions","volume":"21","author":"Johnson","year":"2012","journal-title":"BMJ Qual Saf."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1002\/mds.28556","article-title":"Palliative care and Parkinson's disease: time to move beyond cancer","volume":"36","author":"Kluger","year":"2021","journal-title":"Mov Disord."},{"key":"B65","doi-asserted-by":"publisher","first-page":"e2015061-e","DOI":"10.1001\/jamanetworkopen.2020.15061","article-title":"Effect of short-term integrated palliative care on patient-reported outcomes among patients severely affected with long-term neurological conditions: a randomized clinical trial","volume":"3","author":"Gao","year":"2020","journal-title":"JAMA Network Open."},{"key":"B66","doi-asserted-by":"publisher","first-page":"S37","DOI":"10.1089\/jpm.2017.0392","article-title":"A review of the essential components of quality palliative care in the home","volume":"21","author":"Seow","year":"2018","journal-title":"J Palliat Med."},{"key":"B67","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.pec.2013.07.002","article-title":"Connecting with patients and instilling realism in an era of emerging communication possibilities: a review on palliative care communication heading to telecare practice","volume":"93","author":"van Gurp","year":"2013","journal-title":"Patient Educ Couns."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2021.673893\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T15:51:06Z","timestamp":1628524266000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2021.673893\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,5]]},"references-count":67,"alternative-id":["10.3389\/fneur.2021.673893"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2021.673893","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,5]]},"article-number":"673893"}}