{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T03:09:53Z","timestamp":1785294593579,"version":"3.55.0"},"reference-count":76,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T00:00:00Z","timestamp":1624492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH111600"],"award-info":[{"award-number":["R01MH111600"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH114881"],"award-info":[{"award-number":["R01MH114881"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Concussion symptoms in adolescents typically resolve within 4 weeks. However, 20 \u2013 30% of adolescents experience a prolonged recovery. Abnormalities in tracts implicated in visuospatial attention and emotional regulation (i.e., inferior longitudinal fasciculus, ILF; inferior fronto-occipital fasciculus, IFOF; uncinate fasciculus; UF) have been consistently reported in concussion; yet, to date, there are no objective markers of prolonged recovery in adolescents. Here, we evaluated the utility of diffusion MRI in outcome prediction. Forty-two adolescents (12.1 \u2013 17.9 years; female: 44.0%) underwent a diffusion Magnetic Resonance Imaging (dMRI) protocol within the first 10 days of concussion. Based on days of injury until medical clearance, adolescents were then categorized into SHORT (&amp;lt;28 days; <jats:italic>N<\/jats:italic> = 21) or LONG (&amp;gt;28 days; <jats:italic>N<\/jats:italic> = 21) recovery time. Fractional anisotropy (FA) in the ILF, IFOF, UF, and\/or concussion symptoms were used as predictors of recovery time (SHORT, LONG). Forty-two age- and sex-matched healthy controls served as reference. Higher FA in the ILF (<jats:italic>left<\/jats:italic>: adjusted odds ratio; AOR = 0.36, 95% CI = 0.15 \u2013 0.91, <jats:italic>P<\/jats:italic> = 0.030; <jats:italic>right<\/jats:italic>: AOR = 0.28, 95% CI = 0.10 \u2013 0.83, <jats:italic>P<\/jats:italic> = 0.021), IFOF (<jats:italic>left:<\/jats:italic> AOR = 0.21, 95% CI = 0.07 \u2013 0.66, <jats:italic>P<\/jats:italic> = 0.008; <jats:italic>right<\/jats:italic>: AOR = 0.30, 95% CI = 0.11 \u2013 0.83, <jats:italic>P<\/jats:italic> = 0.020), and UF (<jats:italic>left<\/jats:italic>: AOR = 0.26, 95% CI = 0.09 \u2013 0.74, <jats:italic>P<\/jats:italic> = 0.011; <jats:italic>right:<\/jats:italic> AOR = 0.28, 95% CI = 0.10 \u2013 0.73, <jats:italic>P<\/jats:italic> = 0.010) was associated with SHORT recovery. In additional analyses, while adolescents with SHORT recovery did not differ from HC, those with LONG recovery showed lower FA in the ILF and IFOF (<jats:italic>P<\/jats:italic> &amp;lt; 0.014). Notably, inclusion of dMRI findings increased the sensitivity and specificity (AUC = 0.93) of a prediction model including clinical variables only (AUC = 0.75). Our findings indicate that higher FA in long associative tracts (especially ILF) might inform a more objective and accurate prognosis for recovery time in adolescents following concussion.<\/jats:p>","DOI":"10.3389\/fneur.2021.681467","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T05:19:03Z","timestamp":1624511943000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["White Matter Abnormalities Associated With Prolonged Recovery in Adolescents Following Concussion"],"prefix":"10.3389","volume":"12","author":[{"given":"Jo\u00e3o Paulo","family":"Lima Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony 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