{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T05:29:03Z","timestamp":1776749343086,"version":"3.51.2"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T00:00:00Z","timestamp":1632441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["CoG 818715, SECRETE-HF"],"award-info":[{"award-number":["CoG 818715, SECRETE-HF"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002129","name":"Heart Foundation","doi-asserted-by":"publisher","award":["CVON DOSIS, grant 2014-40"],"award-info":[{"award-number":["CVON DOSIS, grant 2014-40"]}],"id":[{"id":"10.13039\/100002129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002129","name":"Heart Foundation","doi-asserted-by":"publisher","award":["CVON PREDICT2, grant 2018-30"],"award-info":[{"award-number":["CVON PREDICT2, grant 2018-30"]}],"id":[{"id":"10.13039\/100002129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002129","name":"Heart Foundation","doi-asserted-by":"publisher","award":["CVON RED-CVD, grant 2017-11"],"award-info":[{"award-number":["CVON RED-CVD, grant 2017-11"]}],"id":[{"id":"10.13039\/100002129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002129","name":"Heart Foundation","doi-asserted-by":"publisher","award":["CVON SHE-PREDICTS-HF, grant 2017-21"],"award-info":[{"award-number":["CVON SHE-PREDICTS-HF, grant 2017-21"]}],"id":[{"id":"10.13039\/100002129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Accurate measurement of kidney function in patients with neuromuscular disorders is challenging. Cystatin C, a marker not influenced by skeletal muscle degradation, might be of clinical value in these patients.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We consecutively enrolled 39 patients with neuromuscular disorders. We investigated the association of the eGFR, based on plasma creatinine and Cystatin C, with clinical and biochemical variables associated with kidney function, namely age and galectin-3.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Creatinine-based eGFR was 242 (\u00b180) and Cystatin C-based eGFR was 110 (\u00b123) mL\/min\/1.73 m<jats:sup>2<\/jats:sup>. Cystatin C-based eGFR was associated with age (\u03b2 \u22120.63 <jats:italic>p<\/jats:italic> &amp;lt; 0.0001) and galectin-3 levels (\u03b2 \u22120.43 <jats:italic>p<\/jats:italic> &amp;lt; 0.01), while creatinine-based eGFR was not (\u03b2 \u22120.22 <jats:italic>p<\/jats:italic> = 0.20; \u03b2 \u22120.28 <jats:italic>p<\/jats:italic> = 0.10). Sensitivity analyses in Duchenne and Becker patients revealed the same results: Cystatin C-based eGFR was associated with age (\u03b2 \u22120.61 <jats:italic>p<\/jats:italic> &amp;lt; 0.01) and galectin-3 levels (\u03b2 \u22120.43 <jats:italic>p<\/jats:italic> = 0.05), while creatinine-based eGFR was not (\u03b2 \u22120.32 <jats:italic>p<\/jats:italic> = 0.13; \u03b2 \u22120.34 <jats:italic>p<\/jats:italic> = 0.14).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> These data indicate that estimation of renal function in patients with neuromuscular disorders cannot reliably be achieved with creatinine, while Cystatin C appears a reasonable alternative. Since a large proportion of patients with neuromuscular disorders develops heart failure, and requires heart failure medication, adequate monitoring of renal function is warranted.<\/jats:p>","DOI":"10.3389\/fneur.2021.688246","type":"journal-article","created":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T00:44:22Z","timestamp":1632530662000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Kidney Function in Patients With Neuromuscular Disease: Creatinine Versus Cystatin C"],"prefix":"10.3389","volume":"12","author":[{"given":"Elles M.","family":"Screever","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny E.","family":"Kootstra-Ros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce","family":"Doorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jellie A.","family":"Nieuwenhuis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henk E. 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