{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T17:11:28Z","timestamp":1781975488336,"version":"3.54.5"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T00:00:00Z","timestamp":1628553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>Hashimoto's encephalopathy (HE) is an autoimmune encephalopathy that presents with various clinical symptoms, including cognitive deterioration, convulsive seizures, and personality changes. HE is associated with thyroid autoimmunity; however, few cases have been reported to develop as paraneoplastic syndrome. Herein, we report the case of a 73-year-old woman with onset of rapidly progressive dementia. Brain magnetic resonance imaging showed diffuse T2 hyperintensity areas involving the bilateral cerebral white matter, right midbrain tegmental area, left cerebral peduncle, and right middle cerebellar peduncle without clear diffusion hyperintensities and gadolinium enhancement. Her neurological symptoms worsened rapidly, and she presented with the apallic syndrome. Electroencephalogram showed periodic synchronous discharge, suggestive of Creutzfeldt\u2013Jakob disease. However, a brain biopsy revealed infiltration of atypical lymphoid cells expressing CD20, and the anti-NH2 terminal of the \u03b1-enolase antibody was detected, diagnosing the complication with lymphomatosis cerebri and HE. High-dose intravenous methylprednisolone therapy and oral prednisolone with whole cranial irradiation enabled her to have simple conversations and consume food orally; however, severe cognitive impairment persisted. Although HE is a rare complication of malignant lymphoma, clinicians should be aware that it could be strongly suspected if the clinical symptoms worsen in the absence of imaging changes.<\/jats:p>","DOI":"10.3389\/fneur.2021.701178","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T04:40:25Z","timestamp":1628570425000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Case Report: Paraneoplastic Hashimoto's Encephalopathy Associated With Lymphomatosis Cerebri With Periodic Synchronous Discharges Resembling Creutzfeldt\u2013Jakob Disease"],"prefix":"10.3389","volume":"12","author":[{"given":"Ryota","family":"Amano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Setsuro","family":"Tsukada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Kosuge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Yano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenjiro","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Yoneda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsumi","family":"Taki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,8,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/S0140-6736(66)92876-5","article-title":"Hashimoto's disease and encephalopathy","volume":"2","author":"Brain","year":"1966","journal-title":"Lancet."},{"key":"B2","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1212\/WNL.41.2_Part_1.228","article-title":"Hashimoto's encephalopathy: a steroid-responsive disorder associated with high anti-thyroid antibody titers\u2013report of 5 cases","volume":"41","author":"Shaw","year":"1991","journal-title":"Neurology."},{"key":"B3","doi-asserted-by":"publisher","first-page":"e217","DOI":"10.1212\/WNL.0000000000008785","article-title":"Hashimoto encephalopathy in the 21st century","volume":"94","author":"Mattozzi","year":"2020","journal-title":"Neurology."},{"key":"B4","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1186\/s12888-016-0897-3","article-title":"Steroid responsive encephalopathy associated with autoimmune thyroiditis (SREAT) presenting as major depression","volume":"16","author":"Endres","year":"2016","journal-title":"BMC Psychiatry."},{"key":"B5","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3389\/fpsyt.2017.00064","article-title":"Steroid-responsive chronic schizophreniform syndrome in the context of mildly increased antithyroid peroxidase antibodies","volume":"8","author":"Endres","year":"2017","journal-title":"Front Psychiatry."},{"key":"B6","doi-asserted-by":"publisher","first-page":"716","DOI":"10.5692\/clinicalneurol.53.716","article-title":"Hashimoto's encephalopathy presenting periodic synchronous discharge, as a differential diagnosis for Creutzfeldt\u2013Jakob disease","volume":"53","author":"Muramatsu","year":"2013","journal-title":"Rinsho Shinkeigaku."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1016\/0140-6736(92)91265-A","article-title":"Thyroid and other organ-specific autoantibodies in healthy centenarians","volume":"339","author":"Mariotti","year":"1992","journal-title":"Lancet."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1210\/jc.83.4.1121","article-title":"Serum thyroglobulin autoantibodies: prevalence, influence on serum thyroglobulin measurement, and prognostic significance in patients with differentiated thyroid carcinoma","volume":"83","author":"Spencer","year":"1998","journal-title":"J Clin Endocrinol Metab."},{"key":"B9","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1210\/jcem-71-3-661","article-title":"Antithyroid peroxidase autoantibodies in thyroid diseases","volume":"71","author":"Mariotti","year":"1990","journal-title":"J Clin Endocrinol Metab."},{"key":"B10","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.jneuroim.2007.01.018","article-title":"High prevalence of serum autoantibodies against the amino terminal of alpha-enolase in Hashimoto's encephalopathy","volume":"185","author":"Yoneda","year":"2007","journal-title":"J Neuroimmunol."},{"key":"B11","first-page":"365","article-title":"Hashimoto's encephalopathy and autoantibodies","volume":"65","author":"Yoneda","year":"2013","journal-title":"Brain Nerve."},{"key":"B12","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.crad.2016.02.006","article-title":"Lymphomatous involvement of the central nervous system","volume":"71","author":"Bathla","year":"2016","journal-title":"Clin Radiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1159\/000017116","article-title":"Lymphomatosis cerebri presenting as a rapidly progressive dementia: clinical, neuroimaging and pathologic findings","volume":"10","author":"Bakshi","year":"1999","journal-title":"Dement Geriatr Cogn Disord."},{"key":"B14","doi-asserted-by":"publisher","first-page":"e14367","DOI":"10.1097\/MD.0000000000014367","article-title":"Diffuse large B-cell lymphoma of the central nervous system presenting as \u201clymphomatosis cerebri\u201d and dementia in elderly man: case report and review of the literature","volume":"98","author":"Kerbauy","year":"2019","journal-title":"Med."},{"key":"B15","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.critrevonc.2017.03.019","article-title":"Primary central nervous system lymphoma","volume":"113","author":"Citterio","year":"2017","journal-title":"Crit Rev Oncol Hematol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"e183","DOI":"10.1111\/j.1552-6569.2010.00477.x","article-title":"MRI findings in lymphomatosis cerebri: description of a case and revision of the literature","volume":"21","author":"Raz","year":"2011","journal-title":"J Neuroimaging."},{"key":"B17","first-page":"231","article-title":"Successful treatment of subacute sclerosing panencephalitis with long-term intrathecal large dose of alpha-interferon\u2013a case report","volume":"27","author":"Horiguchi","year":"1995","journal-title":"No To Hattatsu."},{"key":"B18","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1177\/155005940403500310","article-title":"case of mild Alzheimer's disease accompanied by periodic synchronous discharges","volume":"35","author":"Ishikawa","year":"2004","journal-title":"Clin EEG Neurosci."},{"key":"B19","first-page":"559","article-title":"Case report of a patient with Hashimoto's encephalopathy associated with Basedow's disease mimicking Creutzfeldt\u2013Jakob disease","volume":"60","author":"Sakurai","year":"2008","journal-title":"Brain Nerve."},{"key":"B20","first-page":"359","article-title":"Case report of Hashimoto's encephalopathy to present symptom of non-herpetic acute limbic encephalopathy (NHALE)","volume":"52","author":"Izumi","year":"2010","journal-title":"Clin Electro."},{"key":"B21","doi-asserted-by":"publisher","first-page":"102488","DOI":"10.1016\/j.msard.2020.102488","article-title":"Lymphomatosis cerebri masquerading as the Marburg variant of multiple sclerosis","volume":"46","author":"Alohaly","year":"2020","journal-title":"Mult Scler Relat Disord."},{"key":"B22","doi-asserted-by":"publisher","first-page":"203","DOI":"10.3988\/jcn.2017.13.2.203","article-title":"Evolution of neurolymphomatosis to lymphomatosis cerebri","volume":"13","author":"Chang","year":"2017","journal-title":"J Clin Neurol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"420","DOI":"10.3340\/jkns.2013.54.5.420","article-title":"Lymphomatosis cerebri","volume":"54","author":"Choi","year":"2013","journal-title":"J Korean Neurosurg Soc."},{"key":"B24","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1159\/000343947","article-title":"Lymphomatosis cerebri Presenting as a Recurrent leukoencephalopathy","volume":"4","author":"Courtois","year":"2012","journal-title":"Case Rep Neurol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"667","DOI":"10.33588\/rn.4611.2007660","article-title":"Lymphomatosis cerebri as the cause of leukoencephalopathy","volume":"46","author":"De Toledo","year":"2008","journal-title":"Rev Neurol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/00207454.2020.1759593","article-title":"Lymphomatosis cerebri with cauda equina lymphoma","volume":"2020","author":"Deng","year":"2020","journal-title":"Int J Neurosci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/WNN.0000000000000048","article-title":"Neurocognitive features distinguishing primary central nervous system lymphoma from other possible causes of rapidly progressive dementia","volume":"28","author":"Deutsch","year":"2015","journal-title":"Cogn Behav Neurol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"760","DOI":"10.11406\/rinketsu.58.76","article-title":"Peripheral T-cell lymphoma, not otherwise specified accompanied by central nervous system involvement with features of lymphomatosis cerebri","volume":"58","author":"Fuseya","year":"2017","journal-title":"Rinsho Ketsueki."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.4103\/0028-3886.273648","article-title":"Slow and steady infiltrates the brain: an autopsy report of lymphomatosis cerebri","volume":"67","author":"Gupta","year":"2019","journal-title":"Neurol India."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.2169\/internalmedicine.54.3283","article-title":"Interleukin 10 level in the cerebrospinal fluid as a possible biomarker for lymphomatosis cerebri","volume":"54","author":"Hashiguchi","year":"2015","journal-title":"Intern Med."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1001\/jamaneurol.2015.1149","article-title":"Lymphomatosis cerebri: a diagnostic challenge","volume":"72","author":"Hatanpaa","year":"2015","journal-title":"J Am Med Assoc Neurol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1111\/j.1440-1789.2011.01203.x","article-title":"An autopsy case of lymphomatosis cerebri showing pathological changes of intravascular large B-cell lymphoma in visceral organs","volume":"31","author":"Hishikawa","year":"2011","journal-title":"Neuropathology."},{"key":"B33","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1159\/000495033","article-title":"Central nervous system peripheral T cell lymphoma manifesting as lymphomatosis cerebri that was misdiagnosed as neuro-Beh\u00e7et's disease: a case report","volume":"11","author":"Imataki","year":"2018","journal-title":"Case Rep Oncol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1093\/neuonc\/nov197","article-title":"Lymphomatosis cerebri: a rare form of primary central nervous system lymphoma. Analysis of 7 cases and systematic review of the literature","volume":"18","author":"Izquierdo","year":"2016","journal-title":"Neuro Oncol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.remn.2013.04.002","article-title":"Primary central nervous system lymphoma with lymphomatosis cerebri in an immunocompetent child: MRI and 18F-FDG PET-CT findings","volume":"32","author":"Jain","year":"2013","journal-title":"Rev Esp Med Nucl Imagen Mol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s11060-007-9437-9","article-title":"A case of \u201clymphomatosis cerebri\u201d diagnosed in an early phase and treated by whole brain radiation: case report and literature review","volume":"86","author":"Kanai","year":"2008","journal-title":"J Neurooncol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s11060-012-0931-3","article-title":"Lymphomatosis cerebri presenting with orthostatic hypotension, anorexia, and paraparesis","volume":"109","author":"Keswani","year":"2012","journal-title":"J Neurooncol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s10014-011-0064-y","article-title":"Lymphomatosis cerebri: clinical characteristics, neuroimaging, and pathological findings","volume":"29","author":"Kitai","year":"2012","journal-title":"Brain Tumor Pathol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"623","DOI":"10.2169\/internalmedicine.5200-20","article-title":"Distribution of deep gray matter lesions on magnetic resonance imaging in lymphomatosis cerebri","volume":"60","author":"Kobayashi","year":"2021","journal-title":"Intern Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1007\/s00415-011-5965-5","article-title":"Lymphomatosis cerebri presenting as a rapidly progressive dementia with a high methylmalonic acid","volume":"258","author":"Leschziner","year":"2011","journal-title":"J Neurol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1136\/jnnp.2006.106385","article-title":"Dementia and leukoencephalopathy due to lymphomatosis cerebri","volume":"78","author":"Lewerenz","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"B42","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1136\/bcr.08.2008.0752","article-title":"Dementia and leukoencephalopathy due to lymphomatosis cerebri","volume":"2008","author":"Lewerenz","year":"2009","journal-title":"BMJ Case Rep."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.3892\/ol.2018.8839","article-title":"Neuroradiological features of lymphomatosis cerebri: a systematic review of the English literature with a new case report","volume":"16","author":"Li","year":"2018","journal-title":"Oncol Lett."},{"key":"B44","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.jns.2019.01.014","article-title":"Lymphomatosis cerebri and anti-NMDAR antibodies: a unique constellation","volume":"398","author":"Mariotto","year":"2019","journal-title":"J Neurol Sci."},{"key":"B45","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1007\/s00415-020-09819-y","article-title":"Parkinsonism as a late presentation of lymphomatosis cerebri following high-dose chemotherapy with autologous stem cell transplantation for primary central nervous system lymphoma","volume":"267","author":"Merrill","year":"2020","journal-title":"J Neurol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/s12883-016-0655-7","article-title":"A case of lymphomatosis cerebri mimicking inflammatory diseases","volume":"16","author":"Murakami","year":"2016","journal-title":"BMC Neurol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.jns.2010.02.023","article-title":"Lymhomatosis cerebri\u2013a rare cause of leukoencephalopathy","volume":"293","author":"Pandit","year":"2010","journal-title":"J Neurol Sci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"201246","DOI":"10.1136\/bcr-2013-201246","article-title":"Lymphomatosis cerebri mimicking iatrogenic Creutzfeldt\u2013Jakob disease","volume":"2014","author":"Rivero Sanz","year":"2014","journal-title":"BMJ Case Rep."},{"key":"B49","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.humpath.2005.01.014","article-title":"Lymphomatosis cerebri as a cause of white matter dementia","volume":"36","author":"Rollins","year":"2005","journal-title":"Hum Pathol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1136\/jnnp-2013-307327","article-title":"Lymphomatosis cerebri: a treatable cause of rapidly progressive dementia","volume":"86","author":"Samani","year":"2015","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"B51","doi-asserted-by":"publisher","first-page":"2561","DOI":"10.2169\/internalmedicine.52.0748","article-title":"Lymphomatosis cerebri with intramedullary spinal cord involvement","volume":"52","author":"Sato","year":"2013","journal-title":"Intern Med."},{"key":"B52","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1111\/j.1440-1789.2009.01004.x","article-title":"Primary central nervous system lymphoma initially mimicking lymphomatosis cerebri: an autopsy case report","volume":"29","author":"Sugie","year":"2009","journal-title":"Neuropathology."},{"key":"B53","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s10014-012-0094-0","article-title":"Primary central nervous system anaplastic large-cell lymphoma mimicking lymphomatosis cerebri","volume":"30","author":"Sugino","year":"2013","journal-title":"Brain Tumor Pathol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"778","DOI":"10.5692\/clinicalneurol.cn-001076","article-title":"Symmetrical lesions of the cerebral peduncles and internal capsules on MRI in a patient with extranodal NK\/T cell lymphoma","volume":"57","author":"Takeuchi","year":"2017","journal-title":"Rinsho Shinkeigaku."},{"key":"B55","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1111\/j.1750-3639.2007.00044_2.x","article-title":"A 64-year-old woman with progressive dementia and leukoencephalopathy","volume":"17","author":"Vital","year":"2007","journal-title":"Brain Pathol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"486","DOI":"10.5692\/clinicalneurol.52.486","article-title":"Remission of lymphomatosis cerebri induced by corticosteroid and high-doses intravenous methotrexate","volume":"52","author":"Watanabe","year":"2012","journal-title":"Rinsho Shinkeigaku."},{"key":"B57","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1097\/01.nrl.0000254706.85609.95","article-title":"Lymphomatosis cerebri presenting as rapidly progressive dementia","volume":"13","author":"Weaver","year":"2007","journal-title":"Neurologist."},{"key":"B58","doi-asserted-by":"publisher","first-page":"286","DOI":"10.5692\/clinicalneurol.cn-001269","article-title":"A case of lymphomatosis cerebri rapidly confirmed by brain biopsy","volume":"59","author":"Yamaguchi","year":"2019","journal-title":"Rinsho Shinkeigaku."},{"key":"B59","doi-asserted-by":"publisher","first-page":"2931","DOI":"10.2169\/internalmedicine.4382-19","article-title":"Pathologically proven gadolinium-enhanced MRI lesions in the bilateral corticospinal tracts in lymphomatosis cerebri","volume":"59","author":"Yamaura","year":"2020","journal-title":"Intern Med."},{"key":"B60","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s40644-017-0128-2","article-title":"Lymphomatosis cerebri: a rare variant of primary central nervous system lymphoma and MR imaging features","volume":"17","author":"Yu","year":"2017","journal-title":"Cancer Imaging."},{"key":"B61","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.jns.2009.09.030","article-title":"Clinical manifestations, diagnostic criteria and therapy of Hashimoto's encephalopathy: report of two cases","volume":"288","author":"Mijajlovic","year":"2010","journal-title":"J Neurol Sci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1111\/j.1365-2141.1987.tb02333.x","article-title":"Spectrum and frequency of autoimmune derangements in lymphoproliferative disorders: analysis of 637 cases and comparison with myeloproliferative diseases","volume":"67","author":"D\u00fchrsen","year":"1987","journal-title":"Br J Haematol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.1183\/09031936.96.09102022","article-title":"Pulmonary B-cell non-Hodgkin's lymphoma associated with autoimmune disorders: a clinicopathological review of six cases","volume":"9","author":"Nicholson","year":"1996","journal-title":"Eur Respir J."},{"key":"B64","doi-asserted-by":"publisher","first-page":"405","DOI":"10.5306\/wjco.v11.i6.405","article-title":"Angioimmunoblastic T-cell lymphoma accompanied by pure red cell aplasia: a case report","volume":"11","author":"Kawahigashi","year":"2020","journal-title":"World J Clin Oncol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/s11060-014-1622-z","article-title":"Diagnostic value of interleukin-10 in cerebrospinal fluid for diffuse large B-cell lymphoma of the central nervous system","volume":"121","author":"Sasagawa","year":"2015","journal-title":"J Neurooncol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1007\/s00415-010-5623-3","article-title":"Soluble CSF interleukin 2 receptor as indicator of neurosarcoidosis","volume":"257","author":"Petereit","year":"2010","journal-title":"J Neurol."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2021.701178\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T04:40:33Z","timestamp":1628570433000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2021.701178\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,10]]},"references-count":66,"alternative-id":["10.3389\/fneur.2021.701178"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2021.701178","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,10]]},"article-number":"701178"}}