{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:30:30Z","timestamp":1762900230975,"version":"3.41.2"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:00:00Z","timestamp":1633910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>We report three cases of pediatric patients suffering from migraine aura triggered seizures. This entity, also called migralepsy, still does not have a unique definition today. Migraine and epilepsy are both episodic neurological disorders with periods of interictal well-being; this is indicative of similar pathophysiological mechanisms, such as increased neuronal excitation and ion channel dysfunction. The purpose of this paper is to discuss the clinical and instrumental features of migralepsy through the description of three clinical cases in which the symptoms of the usual migraine aura developed into a generalized tonic\u2013clonic or focal seizure.<\/jats:p>","DOI":"10.3389\/fneur.2021.711858","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T07:23:18Z","timestamp":1633936998000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Case Report: Migralepsy: The Two-Faced Janus of Neurology"],"prefix":"10.3389","volume":"12","author":[{"given":"Giorgia","family":"Sforza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Ruscitto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romina","family":"Moavero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana","family":"Ursitti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela Ada Noris","family":"Ferilli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuela","family":"Tarantino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Balestri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Vigevano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"Valeriani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Papetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,10,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"771","DOI":"10.3389\/fneur.2019.00771","article-title":"Prophylactic treatment of pediatric migraine: is there anything new in the last decade?","volume":"10","author":"Papetti","year":"2019","journal-title":"Front Neurol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.ncl.2008.11.003","article-title":"Pediatric migraine","volume":"27","author":"Lewis","year":"2009","journal-title":"Neurol Clin."},{"key":"B3","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.yebeh.2012.09.025","article-title":"\u201cHeadache and epilepsy\u201d\u2014how are they connected?","volume":"26","author":"Papetti","year":"2013","journal-title":"Epilepsy Behav."},{"key":"B4","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1111\/j.1528-1167.2012.03711.x","article-title":"Migraine in the borderland of epilepsy: \u201cmigralepsy\u201d an overlapping syndrome of children and adults?","volume":"7","author":"Kasteleijn-Nolst","year":"2012","journal-title":"Epilepsia."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/0333102417738202","article-title":"The International Classification of Headache Disorders, 3rd edition","volume":"38","year":"2018","journal-title":"Cephalalgia"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2487","DOI":"10.1111\/j.1528-1167.2009.02265.x","article-title":"Migralepsy: a call for a revision of the definition","volume":"50","author":"Sances","year":"2009","journal-title":"Epilepsia."},{"key":"B7","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.yebeh.2011.03.004","article-title":"Should \u201cmigralepsy\u201d be considered an obsolete concept? 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