{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:34:40Z","timestamp":1767652480154,"version":"3.41.2"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T00:00:00Z","timestamp":1629936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Defective pantomime of tool use is a hall mark of limb apraxia. Contextual information has been demonstrated to improve tool use performance. Further, knowledge about the potential impact of technological aids such as augmented reality for patients with limb apraxia is still scarce.<\/jats:p><jats:p><jats:bold>Objective:<\/jats:bold> Since augmented reality offers a new way to provide contextual information, we applied it to pantomime of tool use. We hypothesize that the disturbed movement execution can be mitigated by holographic stimulation. If visual stimuli facilitate the access to the appropriate motor program in patients with apraxia, their performance should improve with increased saliency, i.e., should be better when supported by dynamic and holographic cues vs. static and screen-based cues.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Twenty one stroke patients and 23 healthy control subjects were randomized to mime the use of five objects, presented in two <jats:italic>Environments<\/jats:italic> (Screen vs. Head Mounted Display, HMD) and two <jats:italic>Modes<\/jats:italic> (Static vs. Dynamic) resulting in four conditions (Screen<jats:sup>Stat<\/jats:sup>, Screen<jats:sup>Dyn<\/jats:sup>, HMD<jats:sup>Stat<\/jats:sup>, HMD<jats:sup>Dyn<\/jats:sup>), followed by a real tool demonstration. Pantomiming was analyzed by a scoring system using video recordings. Additionally, the sense of presence was assessed using a questionnaire.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Healthy control participants performed close to ceiling and significantly better than patients. Patients achieved significantly higher scores with holographic or dynamic cues. Remarkably, when their performance was supported by animated holographic cues (e.g., striking hammer), it did not differ significantly from real tool demonstration. As the sense of presence increases with animated holograms, so does the pantomiming.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Patients' performance improved with visual stimuli of increasing saliency. Future assistive technology could be implemented upon this knowledge and thus, positively impact the rehabilitation process and a patient's autonomy.<\/jats:p>","DOI":"10.3389\/fneur.2021.711900","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T22:43:31Z","timestamp":1630104211000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Improvement of Apraxia With Augmented Reality: Influencing Pantomime of Tool Use via Holographic Cues"],"prefix":"10.3389","volume":"12","author":[{"given":"Nina","family":"Rohrbach","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Krewer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"L\u00f6hnert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"Thierfelder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Randerath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Jahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Hermsd\u00f6rfer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,8,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1136\/jnnp-2011-300968","article-title":"Systematic assessment of apraxia and functional predictions from the Birmingham Cognitive Screen","volume":"83","author":"Bickerton","year":"2012","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"B2","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1191\/026921500668935800","article-title":"Prevalence of apraxia among patients with a first left hemisphere stroke in rehabilitation centres and nursing homes","volume":"14","author":"Donkervoort","year":"2000","journal-title":"Clin Rehabil."},{"key":"B3","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1080\/13854046.2019.1585575","article-title":"Limb apraxia profiles in different clinical samples","volume":"34","author":"Buchmann","year":"2020","journal-title":"Clin Neuropsychol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/B978-0-444-63622-5.00017-6","article-title":"Limb apraxia and the left parietal lobe","volume":"151","author":"Buxbaum","year":"2018","journal-title":"Handb Clin Neurol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1016\/j.nicl.2018.06.019","article-title":"It takes two to pantomime: communication meets motor cognition","volume":"19","author":"Finkel","year":"2018","journal-title":"NeuroImage Clin."},{"key":"B6","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.cortex.2015.07.023","article-title":"Apraxia and spatial inattention dissociate in left hemisphere stroke","volume":"71","author":"Timpert","year":"2015","journal-title":"Cortex."},{"key":"B7","first-page":"1","volume-title":"Introduction to Limb Apraxia","author":"Rothi","year":"1997"},{"key":"B8","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.1212\/01.wnl.0000247279.63483.1f","article-title":"Rehabilitation of limb apraxia improves daily life activities in patients with stroke","volume":"67","author":"Smania","year":"2006","journal-title":"Neurology."},{"key":"B9","doi-asserted-by":"publisher","first-page":"353","DOI":"10.3389\/fpsyg.2014.00353","article-title":"The tool in the brain: apraxia in ADL. 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