{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:08:12Z","timestamp":1790849292486,"version":"4.1.0"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>A serious complication of acute ischemic stroke (AIS) after mechanical thrombectomy (MT) is hemorrhagic transformation (HT), which is potentially associated with clinical deterioration. This study examined predictors of HT following MT in AIS patients. Patients with AIS due to large artery occlusion in the anterior circulation, treated with MT and successfully recanalized (modified Thrombolysis in Cerebral Infarction score 2b\/3), were studied retrospectively. HT was evaluated by computed tomography (CT) 24 h after MT and was diagnosed and classified into parenchymal hematoma (PH) and hemorrhagic infarction (HI). Multivariate logistic regression models were used to determine the risk factors for HT. Receiver operating characteristic (ROC) curve analysis was performed to determine the predictive utility of risk factors for HT. We enrolled 135 patients: 49 in the HT group and 86 in the non-HT group. The two groups differed significantly in baseline fibrinogen levels (<jats:italic>p<\/jats:italic> = 0.003) and platelet counts (<jats:italic>p<\/jats:italic> = 0.006). Multivariate logistic regression analyses showed that lower fibrinogen levels [odds ratio (OR), 0.41; 95% CI, 0.23\u20130.72; <jats:italic>p<\/jats:italic> = 0.002] and platelet counts (OR, 0.58; 95% CI, 0.33\u20130.99; <jats:italic>p<\/jats:italic> = 0.048) were independently associated with a higher risk of HT. Together, the binary variates fibrinogen and platelets well-predicted HT (area under the curve, 0.703; specificity, 77.9%; sensitivity, 55.1%). The combination of fibrinogen &amp;lt;2.165 g\/L and platelets &amp;lt;171.5 \u00d7 10<jats:sup>9<\/jats:sup>\/L was the strongest predictor of HT (OR, 23.17; 95% CI, 5.75\u2013126.80; <jats:italic>p<\/jats:italic> &amp;lt; 0.0001). Our study suggests that lower baseline fibrinogen levels and platelet counts may be risk factors for HT in AIS patients following MT and reperfusion. Specifically, the combination of fibrinogen level and platelet count may predict the risk of HT after MT in these patients.<\/jats:p>","DOI":"10.3389\/fneur.2021.716020","type":"journal-article","created":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T22:32:57Z","timestamp":1630708377000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Fibrinogen Level Combined With Platelet Count for Predicting Hemorrhagic Transformation in Acute Ischemic Stroke Patients Treated With Mechanical Thrombectomy"],"prefix":"10.3389","volume":"12","author":[{"given":"Changchun","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peisheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianren","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,8,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"l6983","DOI":"10.1136\/bmj.l6983","article-title":"Management of acute ischemic stroke","volume":"368","author":"Phipps","year":"2020","journal-title":"BMJ."},{"key":"B2","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1056\/NEJMoa1713973","article-title":"Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging","volume":"378","author":"Albers","year":"2018","journal-title":"New Eng J Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1056\/NEJMoa1706442","article-title":"Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct","volume":"378","author":"Nogueira","year":"2018","journal-title":"New Eng J Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1016\/S1474-4422(16)30177-6","article-title":"Mechanical thrombectomy after intravenous alteplase versus alteplase alone after stroke (THRACE): a randomised controlled trial","volume":"15","author":"Bracard","year":"2016","journal-title":"Lancet Neurol."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.23736\/S0390-5616.20.05141-3","article-title":"Risk factors and functional outcome were associated with hemorrhagic transformation after mechanical thrombectomy for acute large vessel occlusion stroke","author":"Li","year":"2020","journal-title":"J Neurosurg Sci"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.1161\/STROKEAHA.110.604603","article-title":"Collateral flow averts hemorrhagic transformation after endovascular therapy for acute ischemic stroke","volume":"42","author":"Bang","year":"2011","journal-title":"Stroke."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1136\/neurintsurg-2019-014898","article-title":"The impact of general anesthesia, baseline ASPECTS, time to treatment, and IV tPA on intracranial hemorrhage after neurothrombectomy: pooled analysis of the SWIFT PRIME. 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