{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:03:36Z","timestamp":1766084616904,"version":"3.41.2"},"reference-count":48,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T00:00:00Z","timestamp":1633996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>Visuospatial working memory (VSWM) impairment is common in patients with right temporal lobe epilepsy (rTLE). The posterior hippocampus is critical for spatial memory, but the contributions of the different subfields to VSWM deficits remain unclear. Forty-six rTLE patients and 42 healthy controls (HCs) were recruited. Resting-state fMRI (rsfMRI) and structural MRI scans were administered, followed by a VSWM_Nback test. The right posterior hippocampus was automatically segmented, and the surface-based functional connectivity (SBFC) of the subiculum (Sub), CA1, CA3, dentate gyrus (DG), hippocampal tail, and right entorhinal cortex (EC) were compared between groups. Correlation analysis was performed between the altered SBFC and VSWM_Nback scores for rTLE patients. The results showed that rTLE patients underperformed in the VSWM_Nback test, with longer mean reaction time of accurate response (ACCmeanRT) in 0back and 2back condition, lower hit rate (HR) and higher false alarm rate (FAR) in 2back condition. Compared with HCs, the rCA3 in the rTLE group exhibited decreased SBFC with inferior parietal cortex (IPC), temporal lateral cortex (TLC), and posterior visual cortex (PVC) in the right hemisphere as well as the bilateral dorsolateral prefrontal cortex (DLPFC). The SBFC of the rEC and right anterior cingulate cortex (rACC) increased in the rTLE group. Within the rTLE group, the decreased SBFC of the rCA3-rIPC and rCA3-rLTC were correlated with worse VSWM performance. Therefore, the decreased SBFC of the rCA3-rIPC and rCA3-rLTC might be the critical aberrant FC pattern reflecting VSWM impairment in rTLE patients. The mechanism might involve functional disruption between the core subsystem and the medial temporal subsystem of the default mode network (DMN).<\/jats:p>","DOI":"10.3389\/fneur.2021.735689","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T17:24:30Z","timestamp":1634145870000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Disruption in Surface-Based Functional Connectivity in the Right Posterior Hippocampal CA3 Subfield: A Probable Neural Basis of Visuospatial Working Memory Impairment in Patients With Right Temporal Lobe Epilepsy"],"prefix":"10.3389","volume":"12","author":[{"given":"Zongxia","family":"Lv","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zirong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomin","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liluo","family":"Nie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qijia","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinou","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,10,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.eplepsyres.2011.10.009","article-title":"Frontal lobe function in temporal lobe epilepsy","volume":"98","author":"Stretton","year":"2012","journal-title":"Epilepsy Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1016\/j.yebeh.2005.07.004","article-title":"I just want to be normal: a qualitative study exploring how children and adolescents view the impact of intractable epilepsy on their quality of life","volume":"7","author":"Elliott","year":"2005","journal-title":"Epilepsy Behav."},{"key":"B3","first-page":"47","article-title":"Working memory","volume-title":"Psychology of Learning and Motivation: Advances in Research and Theory.","author":"Baddeley","year":"1974"},{"key":"B4","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1002\/hbm.20131","article-title":"N-back working memory paradigm: a meta-analysis of normative functional neuroimaging studies","volume":"25","author":"Owen","year":"2005","journal-title":"Hum Brain Mapp."},{"key":"B5","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.nicl.2017.01.004","article-title":"Alterations in visual cortical activation and connectivity with prefrontal cortex during working memory updating in major depressive disorder","volume":"14","author":"Le","year":"2017","journal-title":"Neuroimage Clin."},{"key":"B6","doi-asserted-by":"publisher","first-page":"374","DOI":"10.4103\/0972-2327.144003","article-title":"Neuropsychological deficits in temporal lobe epilepsy: a comprehensive review","volume":"17","author":"Zhao","year":"2014","journal-title":"Ann Indian Acad Neurol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev-psych-120710-100422","article-title":"Working memory: theories, models, and controversies","volume":"63","author":"Baddeley","year":"2012","journal-title":"Annu Rev Psychol."},{"volume-title":"Visuo-Spatial Working Memory","year":"1995","author":"Logie","key":"B8"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1002\/hbm.21514","article-title":"The organization of intrinsic brain activity differs between genders: a resting-state fMRI study in a large cohort of young healthy subjects","volume":"34","author":"Filippi","year":"2013","journal-title":"Hum Brain Mapp."},{"key":"B10","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.yebeh.2014.04.001","article-title":"Alteration of functional connectivity within visuospatial working memory-related brain network in patients with right temporal lobe epilepsy: a resting-state fMRI study","volume":"35","author":"Lv","year":"2014","journal-title":"Epilepsy Behav."},{"key":"B11","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1136\/jnnp.20.1.11","article-title":"Loss of recent memory after bilateral hippocampal lesions","volume":"20","author":"Scoville","year":"1957","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"B12","doi-asserted-by":"publisher","first-page":"3228","DOI":"10.1073\/pnas.0911531107","article-title":"Cross-frequency coupling supports multi-item working memory in the human hippocampus","volume":"107","author":"Axmacher","year":"2010","journal-title":"Proc Natl Acad Sci USA."},{"key":"B13","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/S0896-6273(01)00411-1","article-title":"Medial temporal lobe activity associated with active maintenance of novel information","volume":"31","author":"Ranganath","year":"2001","journal-title":"Neuron."},{"key":"B14","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.bbr.2013.05.030","article-title":"The hippocampus supports high-resolution binding in the service of perception, working memory and long-term memory","volume":"254","author":"Yonelinas","year":"2013","journal-title":"Behav Brain Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1038\/319774a0","article-title":"Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5","volume":"319","author":"Morris","year":"1986","journal-title":"Nature."},{"key":"B16","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.neubiorev.2021.05.033","article-title":"The nucleus reuniens orchestrates prefrontal-hippocampal synchrony during spatial working memory","volume":"128","author":"Griffin","year":"2021","journal-title":"Neurosci Biobehav Rev."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1111\/epi.12193","article-title":"Structural correlates of impaired working memory in hippocampal sclerosis","volume":"54","author":"Winston","year":"2013","journal-title":"Epilepsia."},{"key":"B18","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1006\/brcg.1999.1095","article-title":"Hippocampal involvement in spatial and working memory: a structural MRI analysis of patients with unilateral mesial temporal lobe sclerosis","volume":"41","author":"Abrahams","year":"1999","journal-title":"Brain Cogn."},{"key":"B19","doi-asserted-by":"publisher","first-page":"3280","DOI":"10.1523\/JNEUROSCI.3420-04.2005","article-title":"A dissociation of encoding and retrieval processes in the human hippocampus","volume":"25","author":"Eldridge","year":"2005","journal-title":"J Neurosci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1016\/j.pnpbp.2009.03.037","article-title":"The role of the CA3 hippocampal subregion in spatial memory: a process oriented behavioral assessment","volume":"33","author":"Gilbert","year":"2009","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry."},{"key":"B21","doi-asserted-by":"publisher","first-page":"101857","DOI":"10.1016\/j.nicl.2019.101857","article-title":"Reduced hippocampal subfield volumes and memory function in school-aged children born preterm with very low birthweight (VLBW)","volume":"23","author":"Aanes","year":"2019","journal-title":"Neuroimage Clin."},{"key":"B22","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1038\/s41593-017-0061-5","article-title":"Dentate network activity is necessary for spatial working memory by supporting CA3 sharp-wave ripple generation and prospective firing of CA3 neurons","volume":"21","author":"Sasaki","year":"2018","journal-title":"Nat Neurosci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1002\/hipo.23164","article-title":"Meta-analytic and functional connectivity evidence from functional magnetic resonance imaging for an anterior to posterior gradient of function along the hippocampal axis","volume":"30","author":"Grady","year":"2020","journal-title":"Hippocampus."},{"key":"B24","doi-asserted-by":"publisher","first-page":"5737","DOI":"10.1038\/s41598-020-62832-z","article-title":"Surface-based analysis increases the specificity of cortical activation patterns and connectivity results","volume":"10","author":"Brodoehl","year":"2020","journal-title":"Sci Rep."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2038","DOI":"10.1093\/cercor\/bhaa343","article-title":"Oscillation-driven memory encoding, maintenance, and recall in an entorhinal-hippocampal circuit model","volume":"31","author":"Kurikawa","year":"2021","journal-title":"Cereb Cortex."},{"key":"B26","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1111\/j.1528-1167.2010.02522.x","article-title":"Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE commission on classification and terminology, 2005-2009","volume":"51","author":"Berg","year":"2010","journal-title":"Epilepsia."},{"key":"B27","doi-asserted-by":"publisher","first-page":"S102","DOI":"10.1016\/S1053-8119(09)70884-5","article-title":"Unbiased nonlinear average age-appropriate brain templates from birth to adulthood","volume":"47","author":"Fonov","year":"2009","journal-title":"Neuroimage"},{"key":"B28","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1016\/j.neuroimage.2012.01.021","article-title":"FreeSurfer","volume":"62","author":"Fischl","year":"2012","journal-title":"Neuroimage."},{"key":"B29","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.neuroimage.2015.04.042","article-title":"A computational atlas of the hippocampal formation using ex vivo, ultra-high resolution MRI: application to adaptive segmentation of in vivo MRI","volume":"115","author":"Iglesias","year":"2015","journal-title":"Neuroimage."},{"key":"B30","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/s41592-018-0235-4","article-title":"fMRIPrep: a robust preprocessing pipeline for functional MRI","volume":"16","author":"Esteban","year":"2019","journal-title":"Nat Methods."},{"key":"B31","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.media.2007.06.004","article-title":"Symmetric diffeomorphic image registration with cross-correlation: evaluating automated labeling of elderly and neurodegenerative brain","volume":"12","author":"Avants","year":"2008","journal-title":"Med Image Anal."},{"key":"B32","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.neuroimage.2016.11.052","article-title":"Towards a consensus regarding global signal regression for resting state functional connectivity MRI","volume":"154","author":"Murphy","year":"2017","journal-title":"Neuroimage."},{"key":"B33","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/nyas.12360","article-title":"The default network and self-generated thought: component processes, dynamic control, and clinical relevance","volume":"1316","author":"Andrews-Hanna","year":"2014","journal-title":"Ann N Y Acad Sci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"e3001275","DOI":"10.1371\/journal.pbio.3001275","article-title":"Intrinsic connectivity reveals functionally distinct cortico-hippocampal networks in the human brain","volume":"19","author":"Barnett","year":"2021","journal-title":"PLoS Biol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"107686","DOI":"10.1016\/j.yebeh.2020.107686","article-title":"Mechanisms of cognitive impairment in temporal lobe epilepsy: a systematic review of resting-state functional connectivity studies","volume":"115","author":"Ives-Deliperi","year":"2021","journal-title":"Epilepsy Behav."},{"key":"B36","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1038\/s41467-019-09569-0","article-title":"Coordinated representational reinstatement in the human hippocampus and lateral temporal cortex during episodic memory retrieval","volume":"10","author":"Pacheco Estefan","year":"2019","journal-title":"Nat Commun."},{"key":"B37","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1101\/lm.850808","article-title":"Prefrontal cortex and hippocampus subserve different components of working memory in rats","volume":"15","author":"Yoon","year":"2008","journal-title":"Learn Mem."},{"key":"B38","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.rehab.2016.01.002","article-title":"Visual perception is dependent on visuospatial working memory and thus on the posterior parietal cortex","volume":"60","author":"Pisella","year":"2017","journal-title":"Ann Phys Rehabil Med."},{"key":"B39","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1177\/0963721411415340","article-title":"The functional organization and capacity limits of working memory","volume":"20","author":"Logie","year":"2011","journal-title":"Curr Direct Psychol Sci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.yebeh.2019.02.031","article-title":"Default mode network deactivation in pediatric temporal lobe epilepsy: relationship to a working memory task and executive function tests","volume":"94","author":"Oyegbile","year":"2019","journal-title":"Epilepsy Behav."},{"key":"B41","doi-asserted-by":"publisher","first-page":"298","DOI":"10.3390\/bs3020298","article-title":"Hippocampal physiology, structure and function and the neuroscience of schizophrenia: a unified account of declarative memory deficits, working memory deficits and schizophrenic symptoms","volume":"3","author":"Wible","year":"2013","journal-title":"Behav Sci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1016\/j.cortex.2012.05.022","article-title":"Dorsolateral prefrontal contributions to human working memory","volume":"49","author":"Barbey","year":"2013","journal-title":"Cortex."},{"key":"B43","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/nature18933","article-title":"A multi-modal parcellation of human cerebral cortex","volume":"536","author":"Glasser","year":"2016","journal-title":"Nature."},{"key":"B44","doi-asserted-by":"publisher","first-page":"10273","DOI":"10.1523\/JNEUROSCI.6386-11.2012","article-title":"Supplementary eye field during visual search: salience, cognitive control, and performance monitoring","volume":"32","author":"Purcell","year":"2012","journal-title":"J Neurosci."},{"key":"B45","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1146\/annurev.neuro.31.061307.090723","article-title":"Place cells, grid cells, and the brain's spatial representation system","volume":"31","author":"Moser","year":"2008","journal-title":"Annu Rev Neurosci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/0168-0102(94)90065-5","article-title":"Ipsilateral connections of the anterior cingulate cortex with the frontal and medial temporal cortices in the macaque monkey","volume":"21","author":"Arikuni","year":"1994","journal-title":"Neurosci Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1093\/brain\/awu100","article-title":"Differential influence of hippocampal subfields to memory formation: insights from patients with temporal lobe epilepsy","volume":"137","author":"Coras","year":"2014","journal-title":"Brain."},{"key":"B48","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/978-1-4684-7971-3_18","article-title":"Anatomical organization of excitatory amino acid receptors and their properties","volume":"203","author":"Cotman","year":"1986","journal-title":"Adv Exp Med Biol."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2021.735689\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T17:24:32Z","timestamp":1634145872000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2021.735689\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,12]]},"references-count":48,"alternative-id":["10.3389\/fneur.2021.735689"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2021.735689","relation":{},"ISSN":["1664-2295"],"issn-type":[{"type":"electronic","value":"1664-2295"}],"subject":[],"published":{"date-parts":[[2021,10,12]]},"article-number":"735689"}}