{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T23:50:08Z","timestamp":1794354608039,"version":"4.9.0"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC0901504"],"award-info":[{"award-number":["2016YFC0901504"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010822","name":"Chengdu Science and Technology Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010822","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Subjective cognitive complaints (SCCs), which are associated with a higher risk of cognitive decline, are widespread in the patients with Parkinson's disease (PD). The previous studies have reported inconsistent factors related to SCCs in the patients with late-onset PD (LOPD), and there is limited information on SCCs in the patients with early-onset PD (EOPD).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    We aimed to investigate the factors associated with SCCs in the drug-na\u00efve patients with EOPD and LOPD without cognitive impairment.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    This cross-sectional study included 332 drug-na\u00efve patients with PD, among whom 134 were EOPD and 198 were LOPD. Motor and non-motor symptoms, such as global objective cognitive status, depression, anxiety, apathy, fatigue, sleep, rapid eye movement sleep behavior disorder, orthostatic hypotension, and excessive daytime sleepiness, were assessed.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Twenty-five (18.66%) patients with EOPD and 49 (24.74%) patients with LOPD reported SCCs. A multivariate binary logistic regression analysis revealed that older age at onset [odds ratio (\n                    <jats:italic>OR<\/jats:italic>\n                    ) = 1.24,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.002], higher apathy score (\n                    <jats:italic>OR<\/jats:italic>\n                    = 1.13,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.003), and lower scores in the visuospatial\/executive abilities (\n                    <jats:italic>OR<\/jats:italic>\n                    = 0.25,\n                    <jats:italic>P<\/jats:italic>\n                    &amp;lt; 0.001) and memory (\n                    <jats:italic>OR<\/jats:italic>\n                    = 0.50,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.024) domains of the Montreal Cognitive Assessment were associated with a higher risk of SCCs in the EOPD group. Higher apathy (\n                    <jats:italic>OR<\/jats:italic>\n                    = 1.06,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.011) and anxiety (\n                    <jats:italic>OR<\/jats:italic>\n                    = 1.14,\n                    <jats:italic>P<\/jats:italic>\n                    &amp;lt; 0.001) scores were associated with SCCs in the LOPD group.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Subjective cognitive complaints are only associated with mood disorders in patients with LOPD. In addition, SCCs may reflect subthreshold cognitive impairment in the patients with EOPD.\n                  <\/jats:p>","DOI":"10.3389\/fneur.2021.749471","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T07:38:55Z","timestamp":1638257935000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Different Associated Factors of Subjective Cognitive Complaints in Patients With Early- and Late-Onset Parkinson's 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