{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T08:28:46Z","timestamp":1792052926890,"version":"4.4.0"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>Stroke is a leading cause of mortality and disability worldwide. Transient ischemic attack (TIA) is defined as transient brain ischemia with temporary neurological deficits. In animal models, prior TIA seems to enhance brain ischemic tolerance to withstand further ischemic events, which might be explained by brain preconditioning. Thus, this review aims to formulate evidence of whether TIAs can induce positive preconditioning and enhance the functional outcomes in patients suffering from subsequent ischemic strokes. Five databases were searched (PubMed, Embase, SAGE, Web of Science, and Scopus), and twelve studies were included in the quantitative analysis. Studies were eligible when comparing patients with acute ischemic stroke (AIS) and previous TIA with those with AIS without TIA. Comparisons included the National Institute of Health Stroke Scale (NIHSS) score at admission and 7 days from the stroke event, modified Rankin score (mRS), and Trial of ORG 10,172 in Acute Stroke Treatment (TOAST) classification. Odds ratio (OR), mean difference (MD), and 95% confidence interval (CI) were used to describe our results using the random effect model. Our results revealed that patients with stroke and prior TIAs had lower NIHSS scores at admission than those without prior TIAs. However, the NIHSS score was not significantly different between the two groups at 7 days. Furthermore, there was no statistically significant difference between both groups in terms of mortality. Despite the differences in the admission mRS score groups, patients with prior TIAs had lower mRS scores at discharge.<\/jats:p>","DOI":"10.3389\/fneur.2021.755167","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T22:44:32Z","timestamp":1638312272000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Transient Ischemic Attacks Preceding Ischemic Stroke and the Possible Preconditioning of the Human Brain: A Systematic Review and Meta-Analysis"],"prefix":"10.3389","volume":"12","author":[{"given":"Sherief","family":"Ghozy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salah Eddine Oussama","family":"Kacimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Elfil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Gomaa","family":"Sobeeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Reda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin M.","family":"Kallmes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro A.","family":"Rabinstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"David R.","family":"Holmes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed","family":"Brinjikji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramanathan","family":"Kadirvel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F.","family":"Kallmes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,11,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e146","DOI":"10.1161\/cir.0000000000000485","article-title":"Heart disease and stroke statistics-2017 update: a report from the american heart association","volume":"135","author":"Benjamin","year":"2017","journal-title":"Circulation."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2361","DOI":"10.1161\/STR.0b013e31829734f2","article-title":"Forecasting the future of stroke in the United States: a policy statement from the American Heart Association and American Stroke Association","volume":"44","author":"Ovbiagele","year":"2013","journal-title":"Stroke."},{"key":"B3","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1161\/01.cir.0000151788.08740.5c","article-title":"Cardiac rehabilitation and secondary prevention of coronary heart disease: an American Heart Association scientific statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Cardiac Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity), in collaboration with the American association of Cardiovascular and Pulmonary Rehabilitation","volume":"111","author":"Leon","year":"2005","journal-title":"Circulation."},{"key":"B4","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1002\/ana.20741","article-title":"1,026 experimental treatments in acute stroke","volume":"59","author":"O'Collins","year":"2006","journal-title":"Ann Neurol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"CD009874","DOI":"10.1002\/14651858.cd009874","article-title":"Increased consumption of fruit and vegetables for the primary prevention of cardiovascular diseases","volume":"2013","author":"Hartley","year":"2013","journal-title":"Cochrane Database Syst Rev."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2532","DOI":"10.1161\/str.0000000000000022","article-title":"Physical activity and exercise recommendations for stroke survivors: a statement for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"45","author":"Billinger","year":"2014","journal-title":"Stroke."},{"key":"B7","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s00234-006-0183-z","article-title":"Reperfusion injury following cerebral ischemia: pathophysiology, MR imaging, and potential therapies","volume":"49","author":"Pan","year":"2007","journal-title":"Neuroradiology."},{"key":"B8","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1152\/physiol.00044.2007","article-title":"Ion transport and energetics during cell death and protection","volume":"23","author":"Murphy","year":"2008","journal-title":"Physiology (Bethesda)."},{"key":"B9","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/s0008-6363(02)00461-3","article-title":"Effect of inhibition of Na(+)\/Ca(2+) exchanger at the time of myocardial reperfusion on hypercontracture and cell death","volume":"55","author":"Inserte","year":"2002","journal-title":"Cardiovasc Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.jphs.2016.05.003","article-title":"LLDT-8 protects against cerebral ischemia\/reperfusion injury by suppressing post-stroke inflammation","volume":"131","author":"Chen","year":"2016","journal-title":"J Pharmacol Sci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"9896","DOI":"10.1074\/jbc.M116.768325","article-title":"Reactive oxygen species production induced by pore opening in cardiac mitochondria: The role of complex II","volume":"292","author":"Korge","year":"2017","journal-title":"J Biol Chem."},{"key":"B12","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/s0008-6363(03)00533-9","article-title":"Mitochondrial permeability transition pore opening during myocardial reperfusion\u2013a target for cardioprotection","volume":"61","author":"Halestrap","year":"2004","journal-title":"Cardiovasc Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1002\/cphy.c160006","article-title":"Ischemia\/Reperfusion","volume":"7","author":"Kalogeris","year":"2016","journal-title":"Compr Physiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1113\/EP087122","article-title":"Ischaemic and hypoxic conditioning: potential for protection of vital organs","volume":"104","author":"Sprick","year":"2019","journal-title":"Exp Physiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/0006-8993(90)90189-i","article-title":"\u2018Ischemic tolerance\u2019 phenomenon found in the brain","volume":"528","author":"Kitagawa","year":"1990","journal-title":"Brain Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/0006-8993(91)90831-f","article-title":"Temporal profile of the effects of pretreatment with brief cerebral ischemia on the neuronal damage following secondary ischemic insult in the gerbil: cumulative damage and protective effects","volume":"553","author":"Kato","year":"1991","journal-title":"Brain Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/jcbfm.1991.62","article-title":"Induced tolerance to ischemia in gerbil hippocampal neurons","volume":"11","author":"Kirino","year":"1991","journal-title":"J Cereb Blood Flow Metab."},{"key":"B18","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/0006-8993(91)91596-s","article-title":"\u2018Ischemic tolerance\u2019 phenomenon detected in various brain regions","volume":"561","author":"Kitagawa","year":"1991","journal-title":"Brain Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1097\/00004647-199607000-00006","article-title":"Stress proteins and tolerance to focal cerebral ischemia","volume":"16","author":"Chen","year":"1996","journal-title":"J Cereb Blood Flow Metab."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1161\/01.str.26.8.1348","article-title":"Silent brain infarcts and transient ischemic attacks. A three-year study of first-ever ischemic stroke patients: the Klosterneuburg Stroke Data Bank","volume":"26","author":"Brainin","year":"1995","journal-title":"Stroke."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1161\/01.str.30.9.1851","article-title":"Attenuated stroke severity after prodromal TIA: a role for ischemic tolerance in the brain?","volume":"30","author":"Weih","year":"1999","journal-title":"Stroke."},{"key":"B22","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1212\/wnl.54.11.2089","article-title":"Do transient ischemic attacks have a neuroprotective effect?","volume":"54","author":"Moncayo","year":"2000","journal-title":"Neurology."},{"key":"B23","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1161\/01.str.0000115767.17923.6a","article-title":"Transient ischemic attacks before ischemic stroke: preconditioning the human brain? A multicenter magnetic resonance imaging study","volume":"35","author":"Wegener","year":"2004","journal-title":"Stroke."},{"key":"B24","doi-asserted-by":"publisher","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/17476348.2021.1932471","article-title":"Association between sarcoidosis and diabetes mellitus: a systematic review and meta-analysis","volume":"2021","author":"Benmelouka","year":"2021","journal-title":"Expert Rev Respir Med."},{"key":"B26","first-page":"1","volume-title":"The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses","author":"Peterson","year":"2011"},{"key":"B27","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur J Epidemiol."},{"key":"B28","volume-title":"R: A Language and Environment for Statistical Computing","year":"2017"},{"key":"B29","article-title":"Identifying and measuring heterogeneity","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins","year":"2011"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/rmv.2147","article-title":"Association of dengue disease severity and blood group: a systematic review and meta-analysis","volume":"31","author":"Hashan","year":"2021","journal-title":"Rev Med Virol."},{"key":"B31","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ."},{"key":"B32","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1001\/jama.295.6.676","article-title":"Comparison of two methods to detect publication bias in meta-analysis","volume":"295","author":"Peters","year":"2006","journal-title":"Jama."},{"key":"B33","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1159\/000080356","article-title":"Relevance of transient ischemic attack to early neurological recovery after nonlacunar ischemic stroke","volume":"18","author":"Arboix","year":"2004","journal-title":"Cerebrovasc Dis."},{"key":"B34","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1159\/000331593","article-title":"Why do acute ischemic stroke patients with a preceding transient ischemic attack present with less severe strokes? Insights from the German Stroke Study","volume":"66","author":"Weber","year":"2011","journal-title":"Eur Neurol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.neulet.2004.12.004","article-title":"Ischemic preconditioning as induction of ischemic tolerance after transient ischemic attacks in human brain: its clinical relevance","volume":"377","author":"Schaller","year":"2005","journal-title":"Neurosci Lett."},{"key":"B36","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1111\/j.1440-1819.2008.01874.x","article-title":"Prior transient ischemic attack is independently associated with lesser in-hospital case fatality in acute stroke","volume":"62","author":"Zsuga","year":"2008","journal-title":"Psychiatry Clin Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1002\/ana.10765","article-title":"The release of tumor necrosis factor-alpha is associated with ischemic tolerance in human stroke","volume":"54","author":"Castillo","year":"2003","journal-title":"Ann Neurol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1136\/jnnp.2003.015875","article-title":"Transient ischaemic attack preceding anterior circulation infarction is independently associated with favourable outcome","volume":"75","author":"Sitzer","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"B39","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.jstrokecerebrovasdis.2008.03.004","article-title":"Transient ischemic attack before nonlacunar ischemic stroke in the elderly","volume":"17","author":"Della Morte","year":"2008","journal-title":"J Stroke Cerebrovasc Dis."},{"key":"B40","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/j.1747-4949.2011.00690.x","article-title":"Thrombolytic therapy for acute ischemic stroke after recent transient ischemic attack","volume":"7","author":"Alonso de Lecinana","year":"2012","journal-title":"Int J Stroke"},{"key":"B41","doi-asserted-by":"publisher","first-page":"552470","DOI":"10.3389\/fneur.2020.552470","article-title":"Inflammatory response of ischemic tolerance in circulating plasma: preconditioning-induced by transient ischemic attack (TIA) phenomena in acute ischemia patients (AIS)","volume":"11","author":"Colas-Campas","year":"2020","journal-title":"Front Neurol."},{"key":"B42","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2307\/2529310","article-title":"The measurement of observer agreement for categorical data","volume":"33","author":"Landis","year":"1977","journal-title":"Biometrics."},{"key":"B43","doi-asserted-by":"publisher","first-page":"3238165","DOI":"10.1155\/2018\/3238165","article-title":"Stroke in the 21(st) century: a snapshot of the burden, epidemiology, and quality of life","volume":"2018","author":"Donkor","year":"2018","journal-title":"Stroke Res Treat."},{"key":"B44","article-title":"Transient ischemic attack","volume-title":"StatPearls","author":"Panuganti","year":"2021"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1056\/NEJMcp020891","article-title":"Clinical practice. Transient ischemic attack","volume":"347","author":"Johnston","year":"2002","journal-title":"N Engl J Med."},{"key":"B46","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1161\/01.str.25.3.715","article-title":"Could transient ischemic attacks have a cerebroprotective role?","volume":"25","author":"Hakim","year":"1994","journal-title":"Stroke."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1161\/01.cir.74.5.1124","article-title":"Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium","volume":"74","author":"Murry","year":"1986","journal-title":"Circulation."},{"key":"B48","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1097\/01.WCB.0000035180.38851.38","article-title":"Cortical spreading depression causes a long-lasting decrease in cerebral blood flow and induces tolerance to permanent focal ischemia in rat brain","volume":"23","author":"Otori","year":"2003","journal-title":"J Cereb Blood Flow Metab."},{"key":"B49","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1212\/01.wnl.0000169031.39264.ff","article-title":"Silent ischemia in minor stroke and TIA patients identified on MR imaging","volume":"65","author":"Coutts","year":"2005","journal-title":"Neurology."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1097\/01.WCB.0000040942.89393.88","article-title":"Ischemic tolerance","volume":"22","author":"Kirino","year":"2002","journal-title":"J Cereb Blood Flow Metab."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1212\/01.wnl.0000240057.71766.71","article-title":"Prior TIA, lipid-lowering drug use, and physical activity decrease ischemic stroke severity","volume":"67","author":"Deplanque","year":"2006","journal-title":"Neurology."},{"key":"B52","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1002\/ana.410330215","article-title":"Delayed peripartum vasculopathy: cerebral eclampsia revisited","volume":"33","author":"Raps","year":"1993","journal-title":"Ann Neurol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1212\/wnl.55.10.1596","article-title":"Do transient ischemic attacks have a neuroprotective effect?","volume":"55","author":"Caplan","year":"2000","journal-title":"Neurology."},{"key":"B54","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1001\/archneur.55.4.481","article-title":"Different predictors of neurological worsening in different causes of stroke","volume":"55","author":"Yamamoto","year":"1998","journal-title":"Arch Neurol."},{"key":"B55","first-page":"5164","article-title":"Study on influence of transient ischemic attack on subsequent cerebral infarction","volume":"20","author":"Huang","year":"2016","journal-title":"Eur Rev Med Pharmacol Sci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"2376","DOI":"10.1016\/j.biocel.2004.05.003","article-title":"Autophagy, proteasomes, lipofuscin, and oxidative stress in the aging brain","volume":"36","author":"Keller","year":"2004","journal-title":"Int J Biochem Cell Biol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.1016\/j.eplepsyres.2005.07.015","article-title":"The neurobiology of aging","author":"Kelly","year":"2006","journal-title":"Epilepsy Res 68 Suppl 1."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1212\/WNL.0b013e318271f76a","article-title":"Upper limb ischemic preconditioning prevents recurrent stroke in intracranial arterial stenosis","volume":"79","author":"Meng","year":"2012","journal-title":"Neurology."},{"key":"B59","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1161\/STROKEAHA.113.001346","article-title":"Remote ischemic perconditioning as an adjunct therapy to thrombolysis in patients with acute ischemic stroke: a randomized trial","volume":"45","author":"Hougaard","year":"2014","journal-title":"Stroke."},{"key":"B60","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/s13311-015-0358-6","article-title":"Ischemic conditioning is safe and effective for octo- and nonagenarians in stroke prevention and treatment","volume":"12","author":"Meng","year":"2015","journal-title":"Neurotherapeutics."},{"key":"B61","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1159\/000447536","article-title":"The interventional effect of remote ischemic preconditioning on cerebral small vessel disease: a pilot randomized clinical trial","volume":"76","author":"Mi","year":"2016","journal-title":"Eur Neurol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1161\/STROKEAHA.116.016429","article-title":"RECAST (remote ischemic conditioning after stroke trial): a pilot randomized placebo controlled phase II trial in acute ischemic stroke","volume":"48","author":"England","year":"2017","journal-title":"Stroke."},{"key":"B63","doi-asserted-by":"publisher","first-page":"3064","DOI":"10.1161\/STROKEAHA.117.017691","article-title":"Remote ischemic conditioning may improve outcomes of patients with cerebral small-vessel disease","volume":"48","author":"Wang","year":"2017","journal-title":"Stroke."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1161\/CIRCULATIONAHA.116.024807","article-title":"Safety and efficacy of remote ischemic preconditioning in patients with severe carotid artery stenosis before carotid artery stenting: a proof-of-concept, randomized controlled trial","volume":"135","author":"Zhao","year":"2017","journal-title":"Circulation."},{"key":"B65","doi-asserted-by":"publisher","first-page":"CD012503","DOI":"10.1002\/14651858.CD012503.pub2","article-title":"Remote ischaemic conditioning for preventing and treating ischaemic stroke","volume":"7","author":"Zhao","year":"2018","journal-title":"Cochrane Database Syst Rev."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2021.755167\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T14:26:10Z","timestamp":1642429570000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2021.755167\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,24]]},"references-count":65,"alternative-id":["10.3389\/fneur.2021.755167"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2021.755167","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,24]]},"article-number":"755167"}}