{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T02:52:25Z","timestamp":1793674345354,"version":"4.5.1"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003500","name":"Universit\u00e0 degli Studi di Padova","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003500","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mild cognitive impairment in Parkinson's disease (PD-MCI) is associated with faster cognitive decline and conversion to dementia. There is uncertainty about the role of \u03b2-amyloid (A\u03b2) co-pathology and its contribution to the variability in PD-MCI profile and cognitive progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To study how presence of A\u03b2 affects clinical and cognitive manifestations as well as regional brain volumes in PD-MCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Twenty-five PD-MCI patients underwent simultaneous PET\/3T-MRI with [\n                      <jats:sup>18<\/jats:sup>\n                      F]flutemetamol and a clinical and neuropsychological examination allowing level II diagnosis. We tested pairwise differences in motor, clinical, and cognitive features with Mann\u2013Whitney U test. We calculated [\n                      <jats:sup>18<\/jats:sup>\n                      F]flutemetamol (FMM) standardized uptake value ratios (SUVR) in striatal and cortical ROIs, and we performed a univariate linear regression analysis between the affected cognitive domains and the mean SUVR. Finally, we investigated differences in cortical and subcortical brain regional volumes with magnetic resonance imaging (MRI).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 8 A\u03b2+ and 17 A\u03b2- PD-MCI. They did not differ for age, disease duration, clinical, motor, behavioral, and global cognition scores. PD-MCI-A\u03b2+ showed worse performance in the overall executive domain (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.037). Subcortical ROIs analysis showed significant A\u03b2 deposition in PD-MCI-A\u03b2+ patients in the right caudal and rostral middle frontal cortex, in precuneus, in left paracentral and pars triangularis (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.0001), and bilaterally in the putamen (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.038). Cortical regions with higher amyloid load correlated with worse executive performances (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.05). Voxel-based morphometry (VBM) analyses showed no between groups differences.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Presence of cerebral A\u03b2 worsens executive functions, but not motor and global cognitive abilities in PD-MCI, and it is not associated with middle-temporal cortex atrophy. These findings, together with the observation of significant proportion of PD-MCI-A\u03b2-, suggest that A\u03b2 may not be the main pathogenetic determinant of cognitive deterioration in PD-MCI, but it would rather aggravate deficits in domains vulnerable to Parkinson primary pathology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2021.760518","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T23:57:21Z","timestamp":1646092641000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["Quantification of Brain \u03b2-Amyloid Load in Parkinson's Disease With Mild Cognitive Impairment: A PET\/MRI 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