{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:32:50Z","timestamp":1792290770568,"version":"4.4.0"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T00:00:00Z","timestamp":1641859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:title>Graphical Abstract<\/jats:title><jats:p\/>","DOI":"10.3389\/fneur.2021.782317","type":"journal-article","created":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T07:57:06Z","timestamp":1665129426000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Platelet, Plasma, Urinary Tryptophan-Serotonin-Kynurenine Axis Markers in Hyperacute Brain Ischemia Patients: A Prospective Study"],"prefix":"10.3389","volume":"12","author":[{"given":"Luigi F.","family":"Saccaro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Pico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Laure","family":"Chadenat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Richard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marie","family":"Launay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Bastenaire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Jullien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jer\u00f4me","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Feuga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryline","family":"Macquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Callebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odile","family":"Spreux-Varoquaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,1,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/S1474-4422(19)30034-1","article-title":"Global, regional, and national burden of stroke, 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"18","author":"Johnson","year":"2019","journal-title":"Lancet Neurol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1001\/jamaneurol.2019.3063","article-title":"Rate and prognosis of brain ischemia in patients with lower-risk transient or persistent minor neurologic events","volume":"76","author":"Coutts","year":"2019","journal-title":"J Am Med Assoc Neurol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fneur.2019.00778","article-title":"Systematic review on the involvement of the kynurenine pathway in stroke: pre-clinical and clinical evidence","volume":"10","author":"Colpo","year":"2019","journal-title":"Front Neurol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"32438592","DOI":"10.3390\/metabo10050208","article-title":"Tryptophan metabolism, inflammation, and oxidative stress in patients with neurovascular disease","volume":"10","author":"Hajsl","year":"","journal-title":"Metabolites"},{"key":"B5","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1007\/s12031-013-0097-2","article-title":"Inflammation-induced catabolism of tryptophan and tyrosine in acute ischemic stroke","volume":"51","author":"Ormstad","year":"2013","journal-title":"J Mol Neurosci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1097\/FJC.0b013e31822f6b8d","article-title":"Modulation of vasoactivity and platelet aggregation by selective 5-HT receptor antagonism in humans","volume":"58","author":"Moerland","year":"2011","journal-title":"J Cardiovasc Pharmacol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.4088\/JCP.v65n1209","article-title":"Cerebrovascular effects of selective serotonin reuptake inhibitors: a systematic review","volume":"65","author":"Ramasubbu","year":"2004","journal-title":"J Clin Psychiatry United States."},{"key":"B8","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1159\/000498911","article-title":"Serotonergic regulation and cognition after stroke: the role of antidepressant treatment and genetic variation","volume":"47","author":"Damsbo","year":"2019","journal-title":"Cerebrovasc Dis."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.1373\/clinchem.2004.037465","article-title":"Simultaneous measurement of kynurenine and tryptophan in human plasma and supernatants of cultured human cells by HPLC with coulometric detection","volume":"50","author":"Maneglier","year":"2004","journal-title":"Clin Chem England."},{"key":"B10","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/S0024-3205(01)01158-4","article-title":"Differential abnormalities in plasma 5-HIAA and platelet serotonin concentrations in violent suicide attempters: relationships with impulsivity and depression","volume":"69","author":"Spreux-Varoquaux","year":"2001","journal-title":"Life Sci Netherlands."},{"key":"B11","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/S0009-9236(99)90071-1","article-title":"Decreased platelet serotonin transporter sites and increased platelet inositol triphosphate levels in patients with unipolar depression: effects of clomipramine and fluoxetine","volume":"66","author":"Alvarez","year":"1999","journal-title":"Clin Pharmacol Ther United States."},{"key":"B12","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1159\/000488364","article-title":"The serotonin transporter gene polymorphisms and risk of ischemic stroke","volume":"45","author":"Mortensen","year":"2018","journal-title":"Cerebrovasc Dis."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1111\/j.1460-9568.2007.05838.x","article-title":"Altered kynurenine metabolism correlates with infarct volume in stroke","volume":"26","author":"Darlington","year":"2007","journal-title":"Eur J Neurosci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1007\/s11064-010-0187-2","article-title":"The role of tryptophan catabolism along the kynurenine pathway in acute ischemic stroke","volume":"35","author":"Brouns","year":"2010","journal-title":"Neurochem Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.2174\/1381612822666151214125950","article-title":"The kynurenine pathway in the acute and chronic phases of cerebral ischemia","volume":"22","author":"Cuartero","year":"2016","journal-title":"Curr Pharm Des."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2021.782317\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T07:57:10Z","timestamp":1665129430000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2021.782317\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,11]]},"references-count":15,"alternative-id":["10.3389\/fneur.2021.782317"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2021.782317","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,11]]},"article-number":"782317"}}