{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T04:23:13Z","timestamp":1793074993040,"version":"4.5.0"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T00:00:00Z","timestamp":1644192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"Objective<\/jats:title>To investigate the efficacy and safety of ultrasound-guided nerve hydrodissection (HD) with 5% dextrose (D5W) as add-on therapy after corticosteroid injection in carpal tunnel syndrome (CTS), and provide a novel strategy.<\/jats:p><\/jats:sec>Methods<\/jats:title>In this retrospective study, patients with CTS who received ultrasound-guided nerve HD with D5W as add-on therapy after corticosteroid injection (combination group) were enrolled. Patients who received corticosteroid injection without add-on therapy (steroid group) were recruited as the control group. Ultrasound-guided nerve HD with D5W was performed 4 weeks after corticosteroid injection. Treatment effectiveness were assessed by visual analog scale (VAS) and Boston Carpal Tunnel Syndrome Questionnaire (BCTQ). The assessment was performed at baseline and 4, 8, and 12 weeks after corticosteroid injection. In addition, adverse events were recorded in this study.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 49 patients and 62 wrists meeting the criteria were included, with 24 patients and 31 wrists in the steroid group and 25 patients and 31 wrists in the combination group. Compared with baseline data, both groups showed greater improvement in VAS, BCTQs (BCTQ severity), and BCTQf (BCTQ function) at 4, 8, and 12 weeks follow-up. VAS, BCTQs, and BCTQf scores at baseline and week 4 were comparable between steroid group and combination group. Compared with steroid group, combination group exhibited a significant reduction in VAS, BCTQs, and BCTQf at 8- and 12-week follow-up (P<\/jats:italic> \u2264 0.01). No adverse event occurred in any group.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our results showed that ultrasound-guided nerve HD with D5W as add-on therapy after corticosteroid injection was efficacious and safe in CTS, and combination therapy is more beneficial than corticosteroid monotherapy in the improvement of symptoms and function at 8- and 12-week follow-up.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2021.782319","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T06:19:22Z","timestamp":1644214762000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Ultrasound-Guided Nerve Hydrodissection With 5% Dextrose 4 Weeks After Steroid Injection in Treatment of Carpal Tunnel Syndrome: A Retrospective Study"],"prefix":"10.3389","volume":"12","author":[{"given":"Juan-juan","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-mei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zu-lin","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang-shan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-hai","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-xi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.ocl.2016.03.005","article-title":"Acute carpal tunnel syndrome: a review of current literature","volume":"47","author":"Gillig","year":"2016","journal-title":"Orthop Clin North Am."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1016\/S1474-4422(16)30231-9","article-title":"Carpal tunnel syndrome: clinical features, diagnosis, and management","volume":"15","author":"Padua","year":"2016","journal-title":"Lancet Neurol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"e7333","DOI":"10.7759\/cureus.7333","article-title":"Carpal tunnel syndrome: a review of literature","volume":"12","author":"Genova","year":"2020","journal-title":"Cureus."},{"key":"B4","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1136\/bmj.319.7214.884","article-title":"Injection with methylprednisolone proximal to the carpal tunnel: randomised double blind trial","volume":"319","author":"Dammers","year":"1999","journal-title":"BMJ."},{"key":"B5","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1002\/ana.25332","article-title":"Randomized double-blinded clinical trial of 5% dextrose versus triamcinolone injection for carpal tunnel syndrome patients","volume":"84","author":"Wu","year":"2018","journal-title":"Ann Neurol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.2147\/JPR.S247208","article-title":"Ultrasound-guided nerve hydrodissection for pain management: rationale, methods, current literature, and theoretical mechanisms","volume":"13","author":"Lam","year":"2020","journal-title":"J Pain Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1016\/j.mayocp.2017.05.025","article-title":"Six-month efficacy of perineural dextrose for carpal tunnel syndrome: a prospective, randomized, double-blind, controlled trial","volume":"92","author":"Wu","year":"2017","journal-title":"Mayo Clin Proc."},{"key":"B8","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/s41598-017-00224-6","article-title":"Six-month efficacy of platelet-rich plasma for carpal tunnel syndrome: a prospective randomized, single-blind controlled trial","volume":"7","author":"Wu","year":"2017","journal-title":"Sci Rep."},{"key":"B9","doi-asserted-by":"publisher","first-page":"E175","DOI":"10.36076\/ppj.2020\/23\/E175","article-title":"Efficacy of hyalase hydrodissection in the treatment of carpal tunnel syndrome: a randomized, double-blind, controlled, clinical trial","volume":"23","author":"Elawamy","year":"2020","journal-title":"Pain Physician."},{"key":"B10","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1249\/JSR.0000000000000226","article-title":"Ultrasound-guided nerve hydrodissection: what is it? 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