{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:29:29Z","timestamp":1791584969768,"version":"4.3.4"},"reference-count":61,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T00:00:00Z","timestamp":1641859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> An increased number of otic capsule dehiscence (OCD) variants <jats:italic>relying on the third window pathomechanism<\/jats:italic> have been reported lately. Therefore, a characterization of the anatomical structures involved and an accurate radiological description of the third window (TW) interface location have become essential for improving the diagnosis and appropriate therapeutic modalities. The purpose of this article is to propose a classification based on <jats:italic>clinical<\/jats:italic>, anatomical, and radiological data of third mobile window abnormalities (TMWA) and to discuss the alleged <jats:italic>pathomechanism in lesser-known clinical variants<\/jats:italic>.<\/jats:p><jats:p><jats:bold>Materials and Methods:<\/jats:bold> The imaging records of 259 patients who underwent, over the last 6 years, a high-resolution CT (HRCT) of the petrosal bone for conductive hearing loss were analyzed retrospectively. Patients with degenerative, traumatic, or chronic infectious petrosal bone pathology were excluded. <jats:italic>As cases with a clinical presentation similar to those of a TW syndrome have recently been described in the literature but without these being confirmed radiologically, we thought it necessary to be integrated in a separated branch of this classification as \u201cCT - TMWA.\u201d The same goes for certain intralabyrinthine pathologies also recently reported in the literature, which mimic to some extent the symptoms of a TW pathology. Therefore, we suggest to call them intralabyrinthine TW-like abnormalities<\/jats:italic>.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Temporal bone HRCT and, in some cases, 3T MRI of 97 patients presenting symptomatic or pauci-symptomatic, single or multiple, unilateral or bilateral OCD were used to develop this classification. According to the topography and anatomical structures involved at the site of the interface of the TW, a <jats:italic>third<\/jats:italic>-type classification of OCD is proposed.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> A classification reuniting all types of TMWA as the one proposed in this article would allow for a better systematization and understanding of this complex pathology and possibly paves the way for innovative therapeutic approaches. <jats:italic>To encompass all clinical and radiological variants of TMWA reported in the literature so far, TMWAs have been conventionally divided into two major subgroups: Extralabyrinthine (or \u201ctrue\u201d OCD with three subtypes) and Intralabyrinthine (in which an additional mobile window-like mechanism is highly suspected) or TMWA-like subtype. Along these subgroups, clinical forms of OCD with multiple localization (multiple OCD) and those that, despite the fact that they have obvious characteristics of OCD have a negative CT scan (or CT \u2013 TMWA), were also included<\/jats:italic>.<\/jats:p>","DOI":"10.3389\/fneur.2021.792545","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T04:36:10Z","timestamp":1641875770000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Proposal for a Unitary Anatomo-Clinical and Radiological Classification of Third Mobile Window 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