{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:31:36Z","timestamp":1756992696098,"version":"3.41.2"},"reference-count":63,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["F30DC018711","K23DC018302"],"award-info":[{"award-number":["F30DC018711","K23DC018302"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002046","name":"Hearing Health Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>Meniere's disease is an inner ear disorder without a known cause. Endolymphatic hydrops is a swelling of the endolymph spaces that has been observed consistently on post-mortem histology in patients with a history of Meniere's disease but can occur in asymptomatic individuals and in association with other diseases. Since its discovery, Meniere's disease has been a disorder managed primarily by otolaryngologists. Surgical treatments, therefore, have accompanied attempts at medical management. Inspired by patients' sensations of ear fullness and later by the histologic findings of hydrops, surgeons began manipulating the membranous labyrinth to relieve episodes of vertigo while attempting to preserve hearing. This review highlights this history of manipulation of the membranous labyrinth. These procedures indicate a rich history of innovation that parallels developments in otologic surgery. The studies involving patients are uniformly retrospective, with some procedures performed first in animal models of endolymphatic hydrops. Many approaches were endorsed by eminent otologic surgeons. Surgeries on the endolymphatic sac are performed by some surgeons today; however, procedures on the membranous labyrinth resulted in similar symptomatic relief through a minimally invasive technique, in many cases performed using only local anesthetic. Episodic vertigo in patients with Meniere's disease is a distressing symptom, yet spontaneous remissions are common. The reports of procedures on the membranous labyrinth reviewed here consistently indicated fewer vertigo episodes. Variable degrees of hearing loss were common following these procedures, and many were abandoned. Additional innovative surgeries are inevitable, but we must understand better the relationships among endolymphatic hydrops, Meniere's disease pathophysiology, and patient symptoms.<\/jats:p>","DOI":"10.3389\/fneur.2021.794741","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T08:47:05Z","timestamp":1640249225000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["A Historical Perspective on Surgical Manipulation of the Membranous Labyrinth for Treatment of Meniere's Disease"],"prefix":"10.3389","volume":"12","author":[{"given":"Calvin J.","family":"Kersbergen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan K.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,12,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1001\/archneur.58.7.1151","article-title":"Prosper Meniere and his disease","volume":"58","author":"Baloh","year":"2001","journal-title":"Arch Neurol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1017\/S0022215100003947","article-title":"Observations on the pathology of Meniere's syndrome","volume":"63","author":"Hallpike","year":"1938","journal-title":"J Laryngol Otol."},{"key":"B3","first-page":"2310","article-title":"Uber die pathologisch Veranderung bei einem M\u00e9ni\u00e8re-Kranken","volume":"4","author":"Yamakawa","year":"1938","journal-title":"J Otorhinolaryngol Soc Jpn."},{"key":"B4","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1288\/00005537-199303000-00007","article-title":"Symptomatic versus asymptomatic endolymphatic hydrops: a histopathological comparison","volume":"103","author":"Sperling","year":"1993","journal-title":"Laryngoscope."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/00034894800896S201","article-title":"Meniere's disease and endolymphatic hydrops: clinical-histopathological correlations","volume":"89","author":"Fraysse","year":"1980","journal-title":"Ann Otol Rhinol Laryngol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/00034894830920S501","article-title":"Endolymphatic hydrops: an overview and classification","volume":"92","author":"Schuknecht","year":"1983","journal-title":"Ann Otol Rhinol Laryngol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1097\/00129492-200501000-00013","article-title":"Pathophysiology of Meniere's syndrome: are symptoms caused by endolymphatic hydrops?","volume":"26","author":"Merchant","year":"2005","journal-title":"Otol Neurotol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1177\/000348948909801108","article-title":"Meniere's syndrome and endolymphatic hydrops: Double-blind temporal bone study","volume":"98","author":"Rauch","year":"1989","journal-title":"Ann Otol Rhinol Laryngol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1288\/00005537-198408000-00001","article-title":"Otosclerosis and endolymphatic hydrops","volume":"94","author":"Liston","year":"1984","journal-title":"Laryngoscope."},{"key":"B10","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s11940-015-0341-x","article-title":"Treatment of Meniere's disease","volume":"17","author":"Sharon","year":"2015","journal-title":"Curr Treat Options Neurol."},{"volume-title":"A Clinical Analysis of the Inflammatory Affections of the Inner Ear.","year":"1871","author":"Knapp","key":"B11"},{"key":"B12","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1001\/jama.1893.02420730010002a","article-title":"The relief of chronic deafness, tinnitus aurium and tympanic vertigo, by removal of the incus and stapes. 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