{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:22:06Z","timestamp":1791199326471,"version":"4.1.0"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> The objective of this study is to present the rare case of a young girl with idiopathic intracranial hypertension secondary to hypoparathyroidism.<\/jats:p><jats:p><jats:bold>Background:<\/jats:bold> Idiopathic intracranial hypertension is a neurological syndrome characterized by elevated intracranial pressure (&amp;gt; 25 cmH<jats:sub>2<\/jats:sub>O) in the absence of intracerebral abnormalities or hydrocephalus. The pathophysiology of idiopathic intracranial hypertension is unknown, and rare cases of idiopathic intracranial hypertension secondary to hypoparathyroidism have been described. It is supposed that hypocalcemia causes decrease in the absorption of cerebrospinal fluid in arachnoidal granulations.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The workup of the girl with idiopathic intracranial hypertension and hypoparathyroidism included physical examination, blood tests, diagnostic imaging, and lumbar puncture.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> We present a 9-year-old female patient who was hospitalized for headache associated with nausea and vomiting for 3 weeks. She underwent an ophthalmologic examination that revealed papilledema. Lumbar puncture revealed an opening pressure of 65 cm H<jats:sub>2<\/jats:sub>O; cerebrospinal fluid analysis and brain computed tomography scan were normal. The patient started taking acetazolamide. Blood tests revealed hypocalcemia associated with high phosphorus level and undetectable PTH hormone, which led us to suspect hypoparathyroidism. She had never had cramps, paraesthesias, or tetany. Chvostek's and Trousseau's signs were positive. In the neck ultrasonography, parathyroids were not visible. Oral supplementation with calcitriol and calcium was started. Headache, nausea, and vomiting immediately disappeared after the lumbar puncture, and the papilledema improved gradually.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Several anecdotal cases of idiopathic intracranial hypertension secondary to hypoparathyroidism have been described. However, our case report is of particular interest, since the child did not present with typical neurological hypoparathyroidism symptoms. Therefore, we recommend that hypoparathyroidism should be included in diagnostic investigations on children with clinical findings of idiopathic intracranial hypertension, because clinical manifestations of hypoparathyroidism are variable and may involve almost all organ systems.<\/jats:p>","DOI":"10.3389\/fneur.2021.818638","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T09:35:38Z","timestamp":1641807338000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Benign Intracranial Hypertension Due to Hypoparathyroidism: A Case Report"],"prefix":"10.3389","volume":"12","author":[{"given":"Giorgia","family":"Sforza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Deodati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Moavero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Papetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Frattale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Vigevano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Cianfarani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Valeriani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1111\/head.13236","article-title":"Idiopathic Intracranial Hypertension in Children and Adolescents: An Update","volume":"58","author":"Cleves-Bayon","year":"2018","journal-title":"Headache."},{"key":"B2","first-page":"67","article-title":"Idiopathic intracranial hypertension in children: diagnostic and management approach","volume":"16","author":"Albakr","year":"2016","journal-title":"Sudanese J Paediatr"},{"key":"B3","doi-asserted-by":"publisher","first-page":"819","DOI":"10.3389\/fneur.2018.00819","article-title":"Clinical features of pediatric idiopathic intracranial hypertension and applicability of new ICHD-3 criteria","volume":"9","author":"Moavero","year":"2018","journal-title":"Front Neurol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1001\/archneur.1988.00520320065016","article-title":"The incidence of pseudotumor cerebri. 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