{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:37:04Z","timestamp":1787161024737,"version":"build-2736575974"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T00:00:00Z","timestamp":1666569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["222300420411"],"award-info":[{"award-number":["222300420411"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the correlation of serum biological markers and related scales to the occurrence of delayed cerebral ischemia and clinical prognosis in patients with aneurysmal subarachnoid hemorrhage (aSAH) complicated with acute hydrocephalus before admission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The clinical data of 227 patients with pre-admission aSAH complicated with acute hydrocephalus admitted to Henan Provincial People's Hospital from April 2017 to December 2020 were retrospectively analyzed. Patients were grouped according to the presence or absence of delayed cerebral ischemia (DCI) after surgery and the prognosis at 6 months after discharge. Univariate and multivariable logistic regression analysis were performed to analyze the relationship between serum biological indicators combined with aneurysm related clinical score scale and the occurrence and prognosis of delayed cerebral ischemia. ROC curves and nomogram were drawn.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Multivariable Logistic regression analysis showed that high Hunt-Hess grade and surgical clipping were independent risk factors for postoperative DCI (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.05). Older age, higher Hunt-Hess grade, higher CRP and neutrophil levels were independent risk factors for poor prognosis at 6 months after surgery (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.05). ROC curve analysis showed that the area under the curve (AUC) of Hunt-Hess grade and surgical method for predicting DCI in patients with aSAH combined with hydrocephalus after surgery were 0.665 and 0.593. The combined AUC of Hunt-Hess grade and surgical method was 0.685, the sensitivity was 64.9%, and the specificity was 64.7%. The AUC of CRP, neutrophil, age and Hunt-Hess grade for predicting poor prognosis in patients with aSAH combined with hydrocephalus at 6 months after surgery were 0.804, 0.735, 0.596, 0.757, respectively. The combined AUC of CRP, neutrophil, age, Hunt-Hess grade was 0.879, the sensitivity was 79%, and the specificity was 84.5%. According to the correction curve, the predicted probability of the nomogram is basically consistent with the actual probability.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hunt-Hess grade and surgical method are independent predictors of postoperative DCI in patients with aSAH complicated with hydrocephalus. \u201cCRP,\u201d \u201cneutrophil,\u201d \u201cage\u201d and \u201cHunt-Hess grade\u201d at admission are independent predictors of clinical prognosis in patients with aSAH complicated with hydrocephalus. The combination of the above indicators has high predictive value.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2022.1014501","type":"journal-article","created":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T04:41:53Z","timestamp":1666586513000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Risk factors and predictive models of poor prognosis and delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage complicated with hydrocephalus"],"prefix":"10.3389","volume":"13","author":[{"given":"Lintao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanwan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fandi","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanqiang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongcan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Hernesniemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Andrade-Barazarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1001\/jamaneurol.2019.0006","article-title":"Worldwide incidence of aneurysmal subarachnoid hemorrhage according to region, time period, blood pressure, and smoking prevalence in the population: a systematic review and meta-analysis","volume":"76","author":"Etminan","year":"2019","journal-title":"JAMA Neurol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/S0140-6736(16)30668-7","article-title":"Spontaneous subarachnoid haemorrhage","volume":"389","author":"Macdonald","year":"2017","journal-title":"Lancet."},{"key":"B3","doi-asserted-by":"publisher","first-page":"328","DOI":"10.4103\/0970-9185.137261","article-title":"Principles of neuroanesthesia in aneurysmal subarachnoid hemorrhage","volume":"30","author":"Kundra","year":"2014","journal-title":"J Anaesthesiol Clin Pharmacol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1007\/s12975-020-00867-0","article-title":"Aneurysmal subarachnoid hemorrhage: the last decade","volume":"12","author":"Neifert","year":"2021","journal-title":"Transl Stroke Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"e01547","DOI":"10.1002\/brb3.1547","article-title":"Early stage neuroglobin level as a predictor of delayed cerebral ischemia in patients with aneurysmal subarachnoid hemorrhage","volume":"10","author":"Ding","year":"2020","journal-title":"Brain Behav."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1007\/s00701-022-05321-8","article-title":"Acute hydrocephalus and delayed cerebral infarction after aneurysmal subarachnoid hemorrhage","volume":"164","author":"Masson","year":"2022","journal-title":"Acta Neurochir."},{"key":"B7","doi-asserted-by":"publisher","first-page":"226","DOI":"10.3238\/arztebl.2017.0226","article-title":"Aneurysmal subarachnoid hemorrhage","volume":"114","author":"Petridis","year":"2017","journal-title":"Dtsch Arztebl Int."},{"key":"B8","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.jocn.2011.06.032","article-title":"Prognosis and treatment of acute hydrocephalus following aneurysmal subarachnoid haemorrhage","volume":"19","author":"Lu","year":"2012","journal-title":"J Clin Neurosci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.nec.2009.10.013","article-title":"Hydrocephalus after aneurysmal subarachnoid hemorrhage","volume":"21","author":"Germanwala","year":"2010","journal-title":"Neurosurg Clin N Am."},{"key":"B10","doi-asserted-by":"publisher","first-page":"8584753","DOI":"10.1155\/2017\/8584753","article-title":"Hydrocephalus after subarachnoid hemorrhage: pathophysiology, diagnosis, and treatment","volume":"2017","author":"Chen","year":"2017","journal-title":"Biomed Res Int."},{"key":"B11","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.clineuro.2018.06.044","article-title":"Red blood cell distribution width is an independent predictor of mortality in patients with aneurysmal subarachnoid hemorrhage","volume":"172","author":"Hong","year":"2018","journal-title":"Clin Neurol Neurosurg."},{"key":"B12","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1227\/NEU.0000000000000963","article-title":"Elevated Baseline C-reactive protein as a predictor of outcome after aneurysmal subarachnoid hemorrhage: data from the simvastatin in aneurysmal subarachnoid hemorrhage (Stash) trial","volume":"77","author":"Turner","year":"2015","journal-title":"Neurosurgery."},{"key":"B13","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jcrc.2020.07.018","article-title":"Initial inflammatory response is an independent predictor of unfavorable outcome in patients with good-grade aneurysmal subarachnoid hemorrhage","volume":"60","author":"Guresir","year":"2020","journal-title":"J Crit Care."},{"key":"B14","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.clineuro.2016.02.042","article-title":"Predictors of good functional outcomes and mortality in patients with severe re-bleeding after aneurysmal subarachnoid hemorrhage","volume":"144","author":"Zhao","year":"2016","journal-title":"Clin Neurol Neurosurg."},{"key":"B15","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1177\/0885066616669328","article-title":"Blood glucose variability: a strong independent predictor of neurological outcomes in aneurysmal subarachnoid hemorrhage","volume":"33","author":"Okazaki","year":"2018","journal-title":"J Intensive Care Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"3266","DOI":"10.1161\/STROKEAHA.120.034024","article-title":"Neutrophil counts as promising marker for predicting in-hospital mortality in aneurysmal subarachnoid hemorrhage","volume":"52","author":"Zhang","year":"2021","journal-title":"Stroke."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3171\/2018.1.JNS172925","article-title":"A sustained systemic inflammatory response syndrome is associated with shunt-dependent hydrocephalus after aneurysmal subarachnoid hemorrhage","volume":"130","author":"Wessell","year":"2018","journal-title":"J Neurosurg."},{"key":"B18","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1227\/01.NEU.0000053222.74852.2D","article-title":"Factors related to hydrocephalus after aneurysmal subarachnoid hemorrhage","volume":"52","author":"Dorai","year":"2003","journal-title":"Neurosurgery."},{"key":"B19","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1055\/s-0034-1394189","article-title":"Intraventricular hemorrhage is associated with early hydrocephalus, symptomatic vasospasm, and poor outcome in aneurysmal subarachnoid hemorrhage","volume":"76","author":"Wilson","year":"2015","journal-title":"J Neurol Surg A Cent Eur Neurosurg."},{"key":"B20","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1038\/nm.4361","article-title":"Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in post-hemorrhagic hydrocephalus","volume":"23","author":"Karimy","year":"2017","journal-title":"Nat Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/s00701-021-05088-4","article-title":"Bumetanide lowers acute hydrocephalus in a rat model of subarachnoid hemorrhage","volume":"164","author":"Metayer","year":"2022","journal-title":"Acta Neurochir."},{"key":"B22","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1007\/s00415-011-6243-2","article-title":"Occurrence and impact of delayed cerebral ischemia after coiling and after clipping in the international subarachnoid aneurysm trial (Isat)","volume":"259","author":"Dorhout Mees","year":"2012","journal-title":"J Neurol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1007\/s10143-006-0045-5","article-title":"Comparison between clipping and coiling on the incidence of cerebral vasospasm after aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis","volume":"30","author":"de Oliveira","year":"2007","journal-title":"Neurosurg Rev."},{"key":"B24","doi-asserted-by":"publisher","first-page":"497","DOI":"10.3390\/ijms17040497","article-title":"Aneurysmal subarachnoid hemorrhage and neuroinflammation: a comprehensive review","volume":"17","author":"Lucke-Wold","year":"2016","journal-title":"Int J Mol Sci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1254\/jjp.88.227","article-title":"Cerebrovascular inflammation following subarachnoid hemorrhage","volume":"88","author":"Sercombe","year":"2002","journal-title":"Jpn J Pharmacol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"5050","DOI":"10.3390\/ijms22095050","article-title":"The pathogenesis of hydrocephalus following aneurysmal subarachnoid hemorrhage","volume":"22","author":"Kuo","year":"2021","journal-title":"Int J Mol Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"5028","DOI":"10.3390\/ijms16035028","article-title":"Methemoglobin is an endogenous toll-like receptor 4 ligand-relevance to subarachnoid hemorrhage","volume":"16","author":"Kwon","year":"2015","journal-title":"Int J Mol Sci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"739506","DOI":"10.3389\/fncel.2021.739506","article-title":"Inflammation and oxidative stress: potential targets for improving prognosis after subarachnoid hemorrhage","volume":"15","author":"Wu","year":"2021","journal-title":"Front Cell Neurosci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s12028-010-9432-4","article-title":"Relevance of cerebral interleukin-6 after aneurysmal subarachnoid hemorrhage","volume":"13","author":"Sarrafzadeh","year":"2010","journal-title":"Neurocrit Care."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.3389\/fimmu.2020.01323","article-title":"Pro-inflammatory actions of heme and other hemoglobin-derived damps","volume":"11","author":"Bozza","year":"2020","journal-title":"Front Immunol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/emm.2006.40","article-title":"Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease","volume":"38","author":"Kim","year":"2006","journal-title":"Exp Mol Med."},{"key":"B32","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/1742-2094-10-83","article-title":"The role of microglia and the Tlr4 pathway in neuronal apoptosis and vasospasm after subarachnoid hemorrhage","volume":"10","author":"Hanafy","year":"2013","journal-title":"J Neuroinflammation."},{"key":"B33","doi-asserted-by":"publisher","first-page":"108486","DOI":"10.1016\/j.intimp.2021.108486","article-title":"Pharmacological inhibition of Tlr4-Nf-Kappab signaling by Tak-242 attenuates hydrocephalus after intraventricular hemorrhage","volume":"103","author":"Lin","year":"2022","journal-title":"Int Immunopharmacol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1177\/1073858418809941","article-title":"Astrocytes: heterogeneous and dynamic phenotypes in neurodegeneration and innate immunity","volume":"25","author":"Cunningham","year":"2019","journal-title":"Neuroscientist."},{"key":"B35","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1002\/jcp.26918","article-title":"Mfg-E8 reverses microglial-induced neurotoxic astrocyte (A1) Via Nf-Kappab and Pi3k-Akt pathways","volume":"234","author":"Xu","year":"2018","journal-title":"J Cell Physiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"3024","DOI":"10.3390\/s21093024","article-title":"Recent advances in Crp biosensor based on electrical, electrochemical and optical methods","volume":"21","author":"Noh","year":"2021","journal-title":"Sensors."},{"key":"B37","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1227\/NEU.0b013e31828048ce","article-title":"Correlation among systemic inflammatory parameter, occurrence of delayed neurological deficits, and outcome after aneurysmal subarachnoid hemorrhage","volume":"72","author":"Muroi","year":"2013","journal-title":"Neurosurgery"},{"key":"B38","doi-asserted-by":"publisher","first-page":"3276","DOI":"10.1161\/STROKEAHA.120.030950","article-title":"Crp (C-Reactive Protein) in outcome prediction after subarachnoid hemorrhage and the role of machine learning","volume":"52","author":"Gaastra","year":"2021","journal-title":"Stroke."},{"key":"B39","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/S0065-2423(09)48005-3","article-title":"Proinflammatory cytokines in Crp baseline regulation","volume":"48","author":"Eklund","year":"2009","journal-title":"Adv Clin Chem."},{"key":"B40","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.bbr.2017.11.011","article-title":"Inhibition of leukotriene B4 synthesis protects against early brain injury possibly via reducing the neutrophil-generated inflammatory response and oxidative stress after subarachnoid hemorrhage in rats","volume":"339","author":"Ye","year":"2018","journal-title":"Behav Brain Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1179\/1743132813Y.0000000292","article-title":"Correlation between serum Il-1beta levels and cerebral edema extent in a hypertensive intracerebral hemorrhage rat model","volume":"36","author":"Wei","year":"2014","journal-title":"Neurol Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"e535","DOI":"10.1097\/SCS.0000000000003818","article-title":"The prognosis factors for endovascular coiling of aneurysm in patients with ruptured intracranial aneurysm","volume":"28","author":"Zhang","year":"2017","journal-title":"J Craniofac Surg."},{"key":"B43","doi-asserted-by":"publisher","first-page":"e641","DOI":"10.1016\/j.wneu.2019.05.233","article-title":"Risk and prognostic factors for rupture of intracranial aneurysms during endovascular embolization","volume":"129","author":"Jiang","year":"2019","journal-title":"World Neurosurg."},{"key":"B44","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1055\/s-0039-3400952","article-title":"Microsurgical treatment of 86 anterior choroidal artery aneurysms: analysis of factors influencing the prognosis","volume":"81","author":"Lu","year":"2020","journal-title":"J Neurol Surg A Cent Eur Neurosurg."},{"key":"B45","doi-asserted-by":"publisher","first-page":"226","DOI":"10.5137\/1019-5149.JTN.19752-16.1","article-title":"Factors related to the development of shunt-dependent hydrocephalus following subarachnoid hemorrhage in the elderly","volume":"28","author":"Jeong","year":"2018","journal-title":"Turk Neurosurg."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2022.1014501\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T04:41:55Z","timestamp":1666586515000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2022.1014501\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,24]]},"references-count":45,"alternative-id":["10.3389\/fneur.2022.1014501"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2022.1014501","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,24]]},"article-number":"1014501"}}