{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:06:21Z","timestamp":1753891581143,"version":"3.41.2"},"reference-count":9,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070605"],"award-info":[{"award-number":["82070605"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016079","name":"Science and Technology Department of Xinjiang Uygur Autonomous Region","doi-asserted-by":"publisher","award":["2020A03004-3"],"award-info":[{"award-number":["2020A03004-3"]}],"id":[{"id":"10.13039\/100016079","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>Peripheral nerve injury is one of the rare complications of adult-onset Still's disease (AOSD). We report a 20-year-old woman diagnosed with AOSD combined with severe sensory neuropathy. She presented with a sore throat, joint pain, rash, and lymphadenopathy. After receiving glucocorticoid therapy, her fever, rash, and inflammatory markers improved. Unexpectedly, 3 weeks after the onset, she experienced sudden paresthesia in her extremities, decreased muscle strength, and diminished tendon reflexes. The electrophysiological examination and peripheral nerve biopsy confirmed immune-mediated severe sensory neuropathy. For the first time, we report typical Wallerian degeneration in AOSD patients with sensory neuropathy by nerve biopsy. Compared with other common symptoms, the delayed aggravation of neurological symptoms may be an important characteristic of sensory neuropathy secondary to AOSD. We emphasize that intensive attention to neurological symptoms after general symptoms control, administration of adequate and appropriate prolonged immunosuppressive therapy, and long-term follow-up are essential for these patients.<\/jats:p>","DOI":"10.3389\/fneur.2022.1016393","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T17:21:07Z","timestamp":1666200067000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case report: Wallerian degeneration: The innate-immune response to adult-onset Still's disease peripheral nerve injury"],"prefix":"10.3389","volume":"13","author":[{"given":"Hao","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gui-Qiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,19]]},"reference":[{"key":"B1","first-page":"424","article-title":"Preliminary criteria for classification of adult Still's disease","volume":"19","author":"Yamaguchi","year":"1992","journal-title":"J Rheumatol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.jaut.2018.07.018","article-title":"A comprehensive review on adult onset Still's disease","volume":"93","author":"Giacomelli","year":"2018","journal-title":"J Autoimmun."},{"key":"B3","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1086\/520170","article-title":"Aseptic meningitis and cranial nerve palsy revealing adult-onset Still's disease","volume":"29","author":"Marie","year":"1999","journal-title":"Clin Infect Dis."},{"key":"B4","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1093\/rheumatology\/41.2.216","article-title":"Miller Fisher syndrome in adult onset Still's disease: case report and review of the literature of other neurological manifestations","volume":"41","author":"Desai","year":"2002","journal-title":"Rheumatology."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1007\/s00296-008-0599-3","article-title":"Encephalic large arteries narrowness and peripheral neuropathy in a patient with adult-onset Still's disease","volume":"28","author":"Zhao","year":"2008","journal-title":"Rheumatol Int."},{"key":"B6","doi-asserted-by":"publisher","first-page":"111","DOI":"10.3969\/j.issn.1000-4963.2009.02.023","article-title":"Adult Still's disease complicated by peripheral neuropathy: a case report","volume":"38","author":"Yanxi","year":"2009","journal-title":"J Clin Dermatol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1001\/jamaneurol.2015.2347","article-title":"The importance of rare subtypes in diagnosis and treatment of peripheral neuropathy","volume":"72","author":"Callaghan","year":"2015","journal-title":"JAMA Neurol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1016\/S0140-6736(05)67665-9","article-title":"Guillain-Barr\u00e9 syndrome","volume":"366","author":"Hughes","year":"2005","journal-title":"Lancet."},{"key":"B9","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1146\/annurev-genet-071819-103917","article-title":"The drama of Wallerian degeneration: the cast, crew, and script","volume":"55","author":"Zhang","year":"2021","journal-title":"Annu Rev Genet."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2022.1016393\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T17:21:17Z","timestamp":1666200077000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2022.1016393\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,19]]},"references-count":9,"alternative-id":["10.3389\/fneur.2022.1016393"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2022.1016393","relation":{},"ISSN":["1664-2295"],"issn-type":[{"type":"electronic","value":"1664-2295"}],"subject":[],"published":{"date-parts":[[2022,10,19]]},"article-number":"1016393"}}