{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:35:29Z","timestamp":1792690529598,"version":"4.5.0"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Plasma neurofilament light chain (pNFL) represents one of the scaffolding proteins of central nervous system axonal injury. The aim of this study was to evaluate pNFL as a predictive biomarker for early neurological deterioration (END) in medically managed patients with large vessel occlusion (LVO) and mild presentation (NIHSS &amp;lt; 6).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study was developed from a prospectively collected stroke database, which was conducted at a large academic comprehensive stroke center in western China. Patients who first presented with acute ischemic stroke (AIS) within 24 h of symptom onset were continuously included. Stroke severity was analyzed at admission using the NIHSS score. The pNFL drawn on admission was analyzed with a novel ultrasensitive single-molecule array.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty-nine consecutive patients were included in the analysis, and 19 (48.72%) patients experienced END. Patients who experienced END had significantly higher pNFL levels (mean, 65.20 vs. 48.28 pg\/mL; <jats:italic>P<\/jats:italic> &amp;lt; 0.001) and larger infarct volume (mean, 15.46 vs. 9.56 mL; <jats:italic>P<\/jats:italic> &amp;lt; 0.001). pNFL was valuable for the prediction of END (OR, 1.170; 95% CI, 1.049\u20131.306; <jats:italic>P<\/jats:italic> = 0.005), even after adjusted for age and sex (OR, 1.178; 95% CI, 1.038\u20131.323; <jats:italic>P<\/jats:italic> = 0.006), blood sampling time, baseline NIHSS, TOAST classification, and infarct volume (OR, 1.168; 95% CI, 1.034\u20131.320; <jats:italic>P<\/jats:italic> = 0.012). The area under the ROC curve was 85.0% (95% CI, 0.731\u20130.970; <jats:italic>P<\/jats:italic> &amp;lt; 0.001). The sensitivity was 73.7%, and the specificity was 80%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>END in minor stroke with LVO was distinguishable from those without END following the determination of pNFL in the blood samples within 24 h of onset. The pNFL is a promising biomarker of END in minor stroke with LVO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical trial registration<\/jats:title><jats:p>ChiCTR1800020330.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2022.1019530","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T16:01:26Z","timestamp":1679068886000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Biomarker of early neurological deterioration in minor stroke and proximal large vessel occlusion: A pilot study"],"prefix":"10.3389","volume":"13","author":[{"given":"Zhiqiang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianyan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaodan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingsong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1159\/000341696","article-title":"Transient ischemic attack and minor stroke are the most common manifestations of acute cerebrovascular disease: a prospective, population-based study\u2013the Aarhus TIA study","volume":"40","author":"Von Weitzel-Mudersbach","year":"2013","journal-title":"Neuroepidemiology."},{"key":"B2","doi-asserted-by":"publisher","first-page":"3274","DOI":"10.1161\/STROKEAHA.117.018113","article-title":"Mechanical thrombectomy for minor and mild stroke patients harboring large vessel occlusion in the anterior circulation: a multicenter cohort study","volume":"48","author":"Dargazanli","year":"2017","journal-title":"Stroke."},{"key":"B3","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1177\/2396987317746003","article-title":"Minor stroke due to large artery occlusion. 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