{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:57:28Z","timestamp":1793408248669,"version":"4.5.0"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Body composition analysis is a valuable tool for assessing and monitoring the nutritional status of children with spinal muscular atrophy (SMA). This study was designed to compare the consistency of bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DXA), as the gold standard method for assessing body composition in clinical practice when treating children with type II and III SMA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From 2019 to 2021, we performed a retrospective analysis of body composition by DXA and BIA measurement methods in patients with type II and III SMA treated at a Chinese tertiary children's hospital. Fat mass (FM), muscle mass (MM), bone mineral content (BMC), and visceral fat area (VFA) were compared using paired sample t-tests. We calculated Lin's concordance correlation coefficient (CCC) and Spearman correlation coefficient to verify the correlation between DXA and BIA measurements. Bland\u2013Altman analysis was used to assess the consistency of the two methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty-seven children with type II and III SMA were recruited. Compared with body composition measured by DXA, the average FM measured by BIA is significantly lower (<jats:italic>P<\/jats:italic> &amp;lt;0.001), whereas the average MM, BMC, and VFA measured by BIA are significantly higher (<jats:italic>P<\/jats:italic> &amp;lt; 0.001) in children with SMA. Overall, the difference between MM (Delta [BIA-DAX] = 1.6 kg) and FM (Delta [BIA-DAX] = \u22121.6 kg) measured by DXA and BIA was minor, whereas the difference of VFA (Delta [BIA-DAX] = \u221243.5 cm) was significantly large. Correlation analysis indicated a substantial correlation of MM (CCC = 0.96 [95% confidence interval (CI) = 0.93\u20130.98], <jats:italic>r<\/jats:italic> = 0.967 [<jats:italic>P<\/jats:italic> &amp;lt; 0.0001]) and FM (CCC = 0.95 [95% CI = 0.92\u20130.97], <jats:italic>r<\/jats:italic> = 0.953 [<jats:italic>P<\/jats:italic> &amp;lt; 0.0001]), and poor correlation of BMC (CCC = 0.61 [95% CI = 0.42\u20130.75], <jats:italic>r<\/jats:italic> = 0.612 [<jats:italic>P<\/jats:italic> &amp;lt; 0.0001]) and VFA (CCC = 0.54 [95% CI = 0.33\u20130.70], <jats:italic>r<\/jats:italic> = 0.689 [<jats:italic>P<\/jats:italic> &amp;lt; 0.0001]) measurements between the two methods. The Bland\u2013Altman analysis suggests that the majority of participants were within LOA. In addition, differences in MM and VFA measurements between BIA and DAX increased according to patients' increasing height, whereas differences in FM and BMC did not differ with height.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BIA overestimates MM and underestimates the FM, BMC, and VFA in children with SMA compared with DXA measurements. Overall, the non-invasive, easy-to-use, and repeatable BIA measurements were found to be in good agreement with DXA measurements, especially for FM and MM, which are essential parameters for the nutritional evaluation of children with SMA.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2022.1034894","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T05:40:41Z","timestamp":1668750041000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["A comparative analysis of body composition assessment by BIA and DXA in children with type II and III spinal muscular 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