{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:25:55Z","timestamp":1793125555847,"version":"4.5.0"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T00:00:00Z","timestamp":1673222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We investigated the effects of brain-computer interface (BCI) combined with mental practice (MP) and occupational therapy (OT) on performance in activities of daily living (ADL) in stroke survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Participants were randomized into two groups: experimental (\n                      <jats:italic>n<\/jats:italic>\n                      = 23, BCI controlling a hand exoskeleton combined with MP and OT) and control (\n                      <jats:italic>n<\/jats:italic>\n                      = 21, OT). Subjects were assessed with the functional independence measure (FIM), motor activity log (MAL), amount of use (MAL-AOM), and quality of movement (MAL-QOM). The box and blocks test (BBT) and the Jebsen hand functional test (JHFT) were used for the primary outcome of performance in ADL, while the Fugl-Meyer Assessment was used for the secondary outcome. Exoskeleton activation and the degree of motor imagery (measured as event-related desynchronization) were assessed in the experimental group. For the BCI, the EEG electrodes were placed on the regions of FC3, C3, CP3, FC4, C4, and CP4, according to the international 10\u201320 EEG system. The exoskeleton was placed on the affected hand. MP was based on functional tasks. OT consisted of ADL training, muscle mobilization, reaching tasks, manipulation and prehension, mirror therapy, and high-frequency therapeutic vibration. The protocol lasted 1 h, five times a week, for 2 weeks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was a difference between baseline and post-intervention analysis for the experimental group in all evaluations: FIM (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001,\n                      <jats:italic>d<\/jats:italic>\n                      = 0.56), MAL-AOM (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001,\n                      <jats:italic>d<\/jats:italic>\n                      = 0.83), MAL-QOM (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.006,\n                      <jats:italic>d<\/jats:italic>\n                      = 0.84), BBT (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004,\n                      <jats:italic>d<\/jats:italic>\n                      = 0.40), and JHFT (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001,\n                      <jats:italic>d<\/jats:italic>\n                      = 0.45). Within the experimental group, post-intervention improvements were detected in the degree of motor imagery (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.001) and the amount of exoskeleton activations (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.001). For the control group, differences were detected for MAL-AOM (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001,\n                      <jats:italic>d<\/jats:italic>\n                      = 0.72), MAL-QOM (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.013,\n                      <jats:italic>d<\/jats:italic>\n                      = 0.50), and BBT (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.005,\n                      <jats:italic>d<\/jats:italic>\n                      = 0.23). Notably, the effect sizes were larger for the experimental group. No differences were detected between groups at post-intervention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BCI combined with MP and OT is a promising tool for promoting sensorimotor recovery of the upper limb and functional independence in subacute post-stroke survivors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2022.1041978","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T08:03:40Z","timestamp":1673337820000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["Brain-computer interface combined with mental practice and occupational therapy enhances upper limb motor recovery, activities of daily living, and participation in subacute stroke"],"prefix":"10.3389","volume":"13","author":[{"given":"Aristela de 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