{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:11:43Z","timestamp":1785499903014,"version":"3.56.0"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T00:00:00Z","timestamp":1669939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009101","name":"Education Department of Henan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009101","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Periventricular leukomalacia (PVL) is an essential cause of cerebral palsy in preterm infants, and cystic PVL (cPVL) is the most severe form of the disease. The pathogenesis of cPVL is complex, and immune imbalances and inflammatory responses may play an essential role in it.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p><jats:italic>This study aimed<\/jats:italic> to investigate the correlation between peripheral blood lymphocyte subsets, especially <jats:italic>\u03b3\u03b4<\/jats:italic>T cells with the pathogenesis of cPVL in preterm infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Peripheral blood from preterm infants with GA &amp;lt; 32 weeks and BW &amp;lt; 1,500 g was used in this study and was collected at 34 weeks corrected gestational age and within 24 h after the diagnosis with cranial MRI or cranial ultrasound. The infants were divided into cPVL groups and control groups. Flow cytometry was used to detect peripheral blood <jats:italic>\u03b3\u03b4<\/jats:italic>T, CD3+, CD4+, CD8+, and the proportion of total lymphocytes. Multiplex cell assays were used to detect the concentration of extracellular serum cytokines IL-6, IL-2, IL-8, IL-17A, IL-10, IL-1RA, eotaxin (CCL11), MCP-1 (CCL2), CXCL1, G-CSF, and IFN<jats:italic>\u03b3<\/jats:italic>. A follow-up visit was carried out when the patient was 3 years old.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After correcting for confounding factors, the proportion of peripheral blood <jats:italic>\u03b3\u03b4<\/jats:italic>T in the cPVL group was significantly lower than that in the control group (\u03b2: 0.216; 95% CI: 0.058\u20130.800, <jats:italic>P<\/jats:italic> &amp;lt; 0.022). Peripheral blood <jats:italic>\u03b3\u03b4<\/jats:italic>T (AUC: 0.722, <jats:italic>P<\/jats:italic>=0.006) and multivariate binary regression model (AUC: 0.865, <jats:italic>P<\/jats:italic> &amp;lt; 0.000) have good diagnostic values for cPVL. Peripheral blood <jats:italic>\u03b3\u03b4<\/jats:italic>T has some predictive power for neurodevelopmental outcomes in preterm infants (AUC: 0.743, <jats:italic>P<\/jats:italic> = 0.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It seems that peripheral blood <jats:italic>\u03b3\u03b4<\/jats:italic>T cells are inversely correlated with cPVL, which is not only a risk factor for cPVL disease but also neurodevelopmental outcomes in preterm infants. However, the causality of cPVL and various lymphocytes is unclear and needs further study.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2022.1043142","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T08:47:10Z","timestamp":1669970830000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["The association of \u03b3\u03b4T lymphocytes with cystic leukomalacia in premature 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