{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:04:51Z","timestamp":1753891491367,"version":"3.41.2"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>Copper deficiency is an acquired condition that can lead to neurologic dysfunctions, such as myelopathy, motor neuron impairment, polyneuropathy, cognitive impairment, and optic nerve neuropathy. Associated biological findings are low serum copper and ceruloplasmin levels with low copper urinary excretion. We report the case of a previously healthy 59-year-old man who presented a complex neurological picture starting with symptoms and radiological signs consistent with degenerative myelopathy in the presence of persisting low serum copper and ceruloplasmin despite oral and intravenous copper supplementation. Over time, his symptoms evolved into a motor neuron disease evocating an amyotrophic lateral sclerosis (ALS) phenotype. The potential role of copper deficiency is discussed, together with the difficulties in biomonitoring copper supplementation.<\/jats:p>","DOI":"10.3389\/fneur.2022.1063803","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T11:50:15Z","timestamp":1672833015000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Case report: Motor neuron disease phenotype associated with symptomatic copper deficiency: Challenging diagnosis and treatment"],"prefix":"10.3389","volume":"13","author":[{"given":"Adam","family":"Benkirane","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thibault","family":"Warlop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Ivanoiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Baret","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsa","family":"Wiame","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Haufroid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Duprez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Hantson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1002\/ncp.10582","article-title":"Clinical manifestations of copper deficiency: a case report and review of the literature","volume":"36","author":"Moon","year":"2021","journal-title":"Nutr Clin Pract."},{"key":"B2","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/oby.2008.614","article-title":"Acquired copper deficiency: a potentially serious and preventable complication following gastric bypass surgery","volume":"17","author":"Griffith","year":"2009","journal-title":"Obesity."},{"key":"B3","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1097\/NRL.0b013e31819428a8","article-title":"Copper deficiency myeloneuropathy due to occult celiac disease","volume":"15","author":"Goodman","year":"2009","journal-title":"Neurologist."},{"key":"B4","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1002\/ncp.10328","article-title":"Copper deficiency: causes, manifestations, and treatment","volume":"34","author":"Altarelli","year":"2019","journal-title":"Nutr Clin Pract."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1007\/s00415-006-0259-z","article-title":"Copper deficiency myelopathy induced by repetitive parenteral zinc supplementation during chronic hemodialysis","volume":"253","author":"Yaldizli","year":"2006","journal-title":"J Neurol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1016\/j.neuro.2009.08.008","article-title":"Myelopolyneuropathy and pancytopenia due to copper deficiency and high zinc levels of unknown origin II. 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