{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:07:17Z","timestamp":1785575237259,"version":"3.56.0"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T00:00:00Z","timestamp":1670284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008005","name":"Yonsei University College of Medicine","doi-asserted-by":"publisher","award":["6-2020-0069"],"award-info":[{"award-number":["6-2020-0069"]}],"id":[{"id":"10.13039\/501100008005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to analyze the prevalence and risk factors of neuromuscular complications after lung transplantation (LT), as well as the association between neuromuscular complications and extracorporeal membrane oxygenation (ECMO) support.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively included 201 patients who underwent LT between 2013 and 2020. Patients were classified into three groups based on the presence and the pattern of postoperative leg weakness: no weakness group, asymmetric weakness group, and symmetric weakness group. Comorbidities, duration of ECMO therapy, and postoperative complications were compared between the three groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 201 recipients, 16 (8.0%) and 29 (14.4%) patients developed asymmetric and symmetric leg weakness, respectively. Foot drop was the main complaint in patients with asymmetric weakness. The presumed site of nerve injury in the asymmetric weakness group was the lumbosacral plexus in 8 (50%), peroneal nerve in 4 (25%), sciatic nerve in 2 (12.5%), and femoral nerve in 2 (12.5%) patients. In multivariate analysis, the use of preoperative ECMO was found to be independently associated with asymmetric weakness (OR, 3.590; 95% CI [1.227\u201310.502]). Symmetric leg weakness was associated with age at LT (1.062 [1.002\u20131.125]), diabetes mellitus (2.873 [1.037\u20137.965]), myositis (13.250 [2.179\u201380.584]), postoperative continuous renal replacement therapy (4.858 [1.538\u201315.350]), and duration of stay in the intensive care unit (1.052 [1.015\u20131.090]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>More than 20% of patients developed leg weakness after LT. Early suspicion for peripheral neuropathy is required in patients after LT who used ECMO preoperatively, and who suffered from medical complications after LT.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2022.1066104","type":"journal-article","created":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T05:34:15Z","timestamp":1670304855000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Risk factors for neuromuscular complications in lower limbs after lung transplantation"],"prefix":"10.3389","volume":"13","author":[{"given":"Soomi","family":"Cho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee Eun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byeong Joo","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song Yee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moo Suk","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo-Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Gu","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo Chae","family":"Paik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha Young","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Woo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1097\/MOT.0000000000000753","article-title":"Survival in adult lung transplantation: where are we in 2020?","volume":"25","author":"Bos","year":"2020","journal-title":"Curr Opin Organ Transplant."},{"key":"B2","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1111\/j.1600-6143.2009.02998.x","article-title":"neurological complications following adult lung transplantation","volume":"10","author":"Mateen","year":"2010","journal-title":"Am J Transplant."},{"key":"B3","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1097\/TP.0b013e318280b359","article-title":"Early major neurologic complications after lung transplantation: incidence, risk factors, and outcome","volume":"95","author":"Shigemura","year":"2013","journal-title":"Transplantation."},{"key":"B4","doi-asserted-by":"publisher","first-page":"e353","DOI":"10.1097\/TXD.0000000000000766","article-title":"Neurological sequelae and clinical outcomes after lung transplantation","volume":"4","author":"Smith","year":"2018","journal-title":"Transplant Direct."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.21037\/jtd.2016.06.18","article-title":"Transition to routine use of venoarterial extracorporeal oxygenation during lung transplantation could improve early outcomes","volume":"8","author":"Yu","year":"2016","journal-title":"J Thorac Dis."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e964","DOI":"10.1097\/CCM.0000000000001865","article-title":"In-hospital neurologic complications in adult patients undergoing venoarterial extracorporeal membrane oxygenation: results from the extracorporeal life support organization registry","volume":"44","author":"Lorusso","year":"2016","journal-title":"Crit Care Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1097\/CCM.0000000000002502","article-title":"Neurologic injury in adults supported with veno-venous extracorporeal membrane oxygenation for respiratory failure: findings from the extracorporeal life support organization database","volume":"45","author":"Lorusso","year":"2017","journal-title":"Crit Care Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2774","DOI":"10.21037\/jtd.2017.08.62","article-title":"Neurologic complications during V-V extracorporeal membrane oxygenation: still counting","volume":"9","author":"Pappalardo","year":"2017","journal-title":"J Thorac Dis."},{"key":"B9","doi-asserted-by":"publisher","first-page":"3275","DOI":"10.21037\/jtd.2016.11.48","article-title":"Risk factors and outcome of primary graft dysfunction after lung transplantation in Korea","volume":"8","author":"Moon","year":"2016","journal-title":"J Thorac Dis."},{"key":"B10","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1097\/MAT.0000000000001052","article-title":"The effect of additional stepwise venous inflow on differential hypoxia of veno-arterial extracorporeal membrane oxygenation","volume":"66","author":"Lee","year":"2020","journal-title":"ASAIO J."},{"key":"B11","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.jns.2009.02.308","article-title":"Neurologic complications following lung transplantation","volume":"280","author":"Zivkovic","year":"2009","journal-title":"J Neurol Sci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"e0174092","DOI":"10.1371\/journal.pone.0174092","article-title":"Influence of early neurological complications on clinical outcome following lung transplant","volume":"12","author":"Gamez","year":"2017","journal-title":"PLoS ONE."},{"key":"B13","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1097\/MAT.0000000000001580","article-title":"Is foot drop an underreported sequela of extracorporeal membrane oxygenation?","volume":"3","author":"Bergeron","year":"2021","journal-title":"ASAIO J."},{"key":"B14","doi-asserted-by":"publisher","first-page":"443","DOI":"10.3400\/avd.ra.18-00074","article-title":"Acute limb ischemia","volume":"11","author":"Obara","year":"2018","journal-title":"Ann Vasc Dis."},{"key":"B15","doi-asserted-by":"publisher","first-page":"75","DOI":"10.5152\/npa.2017.19340","article-title":"A case report of a drop foot developed after common femoral artery cannulation for venoarterial extracorporeal membrane oxygenation","volume":"56","author":"Aydin","year":"2019","journal-title":"Noro Psikiyatr Ars."},{"key":"B16","doi-asserted-by":"publisher","first-page":"575","DOI":"10.5535\/arm.2014.38.4.575","article-title":"Delayed onset of acute limb compartment syndrome with neuropathy after venoarterial extracorporeal membrane oxygenation therapy","volume":"38","author":"Go","year":"2014","journal-title":"Ann Rehabil Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1186\/s13054-019-2541-3","article-title":"Limb ischemia in peripheral veno-arterial extracorporeal membrane oxygenation: a narrative review of incidence, prevention, monitoring, and treatment","volume":"23","author":"Bonicolini","year":"2019","journal-title":"Crit Care."},{"key":"B18","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1186\/s12872-020-01675-y","article-title":"Femoral neuropathy following venoarterial-extracorporeal membrane oxygenation therapy: a case report","volume":"20","author":"Jang","year":"2020","journal-title":"BMC Cardiovasc Disord."},{"key":"B19","doi-asserted-by":"publisher","first-page":"101","DOI":"10.4103\/1673-5374.125337","article-title":"Critical illness polyneuropathy and myopathy: a systematic review","volume":"9","author":"Zhou","year":"2014","journal-title":"Neural Regen Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1002\/art.23571","article-title":"Interstitial lung disease in polymyositis and dermatomyositis: longitudinal evaluation by pulmonary function and radiology","volume":"59","author":"Fathi","year":"2008","journal-title":"Arthritis Rheum."},{"key":"B21","doi-asserted-by":"publisher","first-page":"3789","DOI":"10.1007\/s10067-021-05704-9","article-title":"Survival and outcomes after lung transplantation for connective tissue disease-associated interstitial lung diseases","volume":"40","author":"Yang","year":"2021","journal-title":"Clin Rheumatol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1007\/s00134-014-3251-6","article-title":"Screening for critical illness polyneuromyopathy with single nerve conduction studies","volume":"40","author":"Moss","year":"2014","journal-title":"Intensive Care Med."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2022.1066104\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T05:34:18Z","timestamp":1670304858000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2022.1066104\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,6]]},"references-count":22,"alternative-id":["10.3389\/fneur.2022.1066104"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2022.1066104","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,6]]},"article-number":"1066104"}}