{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T06:25:47Z","timestamp":1772000747980,"version":"3.50.1"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T00:00:00Z","timestamp":1646956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Paediatric aneurysms are rare and difficult to treat. Studies on the long-term angiographic and clinical outcomes conducted within the past decade are lacking. We aimed to investigate the clinical and radiographic outcomes of paediatric aneurysms treated with different strategies in a contemporary series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective medical record review of paediatric patients examined at our institution between 2011 and 2018. Patient charts were retrospectively reviewed for age, presentation, type and location of the aneurysm, modalities of treatment, complications, and clinical and angiographic outcomes. The rates of aneurysm recurrence and <jats:italic>de novo<\/jats:italic> formation were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We evaluated 61 patients (mean age, 11.6 years; 23 females, 38 males) with 69 intracranial aneurysms. Their presentations included headache, neurological deficits, aneurysmal subarachnoid haemorrhage, incidental aneurysm, and traumatic subarachnoid haemorrhage. Of the aneurysms, 30 (49.2%) were giant. Forty-five (73.8%) patients underwent treatment for their aneurysms, and 16 (26.2%) patients were managed conservatively. The perioperative morbidity rate was 17.8%. There were no deaths. The long-term morbidity rate was 4.6%. The clinical outcomes were favourable in 82.2 and 95.3% at discharge and follow-up, respectively (mean, 41.5 months; range, 1.5\u20139 years). For treated aneurysms, 2\/43 (4.6%) risk of aneurysm recurrence, 1\/43 (2.3%) risk of aneurysm bleeding, 1\/43 (2.3%) risk of <jats:italic>de novo<\/jats:italic> aneurysm formation. The annual bleeding, recurrence, and <jats:italic>de novo<\/jats:italic> formation or growth risk were 0.7, 1.4, and 0.7%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In neurovascular centres where microsurgical and endovascular options are available, most children with intracranial aneurysms can be successfully treated with low morbidity and mortality. However, they have higher rates of recurrence and a greater risk of <jats:italic>de novo<\/jats:italic> formation or growth than their adult counterparts, which mandates lifelong follow-up.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2022.684093","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T13:50:05Z","timestamp":1647006605000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Paediatric Intracranial Aneurysms: Long-term Angiographic and Clinical Outcomes in a Contemporary Series"],"prefix":"10.3389","volume":"13","author":[{"given":"Junlin","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingtao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanli","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jizong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s00381-004-1125-x","article-title":"Intracranial aneurysms in children aged under 15 years: review of 59 consecutive children with 75 aneurysms","volume":"21","author":"Lasjaunias","year":"2005","journal-title":"Childs Nerv Syst"},{"key":"B2","doi-asserted-by":"publisher","first-page":"340","DOI":"10.3171\/2012.7.PEDS11455","article-title":"Clinical and radiological profiles and outcomes in pediatric patients with intracranial aneurysms","volume":"10","author":"Mehrotra","year":"2012","journal-title":"J Neurosurg Pediatr"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e1203","DOI":"10.1016\/j.wneu.2019.01.280","article-title":"Pediatric intracranial aneurysms: favorable outcomes despite rareness and complexity","volume":"125","author":"Kim","year":"2019","journal-title":"World Neurosurg"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.3174\/ajnr.A1587","article-title":"Intracranial aneurysms in childhood: 27-year single-institution experience","volume":"30","author":"Hetts","year":"2009","journal-title":"AJNR Am J Neuroradiol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1016\/S0140-6736(02)11314-6","article-title":"International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping vs. endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial","volume":"360","author":"Molyneux","year":"2002","journal-title":"Lancet"},{"key":"B6","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/S0140-6736(05)67214-5","article-title":"International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping vs. endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and aneurysm occlusion","volume":"366","author":"Molyneux","year":"2005","journal-title":"Lancet"},{"key":"B7","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1056\/NEJMra052760","article-title":"Cerebral aneurysms","volume":"355","author":"Brisman","year":"2006","journal-title":"N Engl J Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"396","DOI":"10.3171\/jns.1999.91.3.0396","article-title":"Late angiographic follow-up review of surgically treated aneurysms","volume":"91","author":"David","year":"1999","journal-title":"J Neurosurg"},{"key":"B9","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.nic.2013.03.018","article-title":"Pediatric cerebral aneurysms","volume":"23","author":"Gemmete","year":"2013","journal-title":"Neuroimaging Clin N Am"},{"key":"B10","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s00701-005-0481-y","article-title":"Intracranial aneurysms in patients 18 years of age or under, are they different from aneurysms in adult population?","volume":"147","author":"Krishna","year":"2005","journal-title":"Acta Neurochir"},{"key":"B11","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3171\/ped.2006.104.2.3","article-title":"Pediatric intracranial aneurysms: durability of treatment following microsurgical and endovascular management","volume":"104","author":"Sanai","year":"2006","journal-title":"J Neurosurg"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1007\/s00381-005-1152-2","article-title":"The role of endovascular treatment for pediatric aneurysms","volume":"21","author":"Agid","year":"2005","journal-title":"Childs Nerv Syst"},{"key":"B13","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.jocn.2005.07.006","article-title":"Aneurysms in children: review of 15 years experience","volume":"13","author":"Aryan","year":"2006","journal-title":"J Clin Neurosci"},{"key":"B14","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1227\/01.NEU.0000371727.71991.64","article-title":"Microsurgical treatment of pediatric intracranial aneurysms: long-term angiographic and clinical outcomes","volume":"67","author":"Kakarla","year":"2010","journal-title":"Neurosurgery"},{"key":"B15","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/S0140-6736(16)30668-7","article-title":"Spontaneous subarachnoid haemorrhage","volume":"389","author":"Macdonald","year":"2017","journal-title":"Lancet"},{"key":"B16","doi-asserted-by":"publisher","first-page":"328","DOI":"10.3171\/ped.2007.106.4.328","article-title":"Pediatric aneurysms","volume":"106","author":"Agid","year":"2007","journal-title":"J Neurosurg"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2022.684093\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T13:50:07Z","timestamp":1647006607000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2022.684093\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,11]]},"references-count":16,"alternative-id":["10.3389\/fneur.2022.684093"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2022.684093","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,11]]},"article-number":"684093"}}