{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T13:45:31Z","timestamp":1769521531259,"version":"3.49.0"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T00:00:00Z","timestamp":1651190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to evaluate the diagnostic performance of some anatomical variables with regard to endolymphatic sac (ES) and duct (ED), measured by non-contrast three-dimensional sampling perfection with application-optimized contrasts using different flip angle evolutions (3D-SPACE) magnetic resonance imaging (MRI), in differentiating vestibular migraine (VM) from unilateral M\u00e9ni\u00e8re's disease (MD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, 81 patients with VM, 97 patients with unilateral MD, and 50 control subjects were enrolled. The MRI-visualized parameters, such as the distance between the vertical part of the posterior semicircular canal and the posterior fossa (MRI-PP distance) and visibility of vestibular aqueduct (MRI-VA), were measured bilaterally. The diagnostic value of the MRI-PP distance and MRI-VA visibility for differentiating VM from unilateral MD was examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>(1) Compared with the VM patients, patients with unilateral MD exhibited shorter MRI-PP distance and poorer MRI-VA visibility. No differences in the MRI-PP distance and MRI-VA visibility were detected between patients with VM and control subjects. (2) No significant interaural difference in the MRI-PP distance and MRI-VA visibility was observed in patients with VM and those with unilateral MD, respectively. (3) Area under the curve (AUC) showed a low diagnostic value for the MRI-PP distance and MRI-VA visibility, respectively, in differentiating between the VM and unilateral MD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on non-enhanced MRI-visualized measurement, anatomical variables with regard to the endolymphatic drainage system differed significantly between the patients with VM and those with unilateral MD. Further investigations are needed to improve the diagnostic value of these indices in differentiating VM from unilateral MD.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2022.814518","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T06:08:32Z","timestamp":1651212512000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Non-contrast MRI of Inner Ear Detected Differences of Endolymphatic Drainage System Between Vestibular Migraine and Unilateral M\u00e9ni\u00e8re's Disease"],"prefix":"10.3389","volume":"13","author":[{"given":"Yangming","family":"Leng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingzhao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaijun","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3182735","DOI":"10.1155\/2016\/3182735","article-title":"The intimate relationship between vestibular migraine and meniere disease: a review of pathogenesis and presentation","volume":"2016","author":"Liu","year":"2016","journal-title":"Behav Neurol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"265","DOI":"10.3389\/fneur.2014.00265","article-title":"Accompanying symptoms overlap during attacks in meniere's disease and vestibular migraine","volume":"5","author":"Lopez-Escamez","year":"2014","journal-title":"Front Neurol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1212\/01.WNL.0000036903.22461.39","article-title":"Migraine and Meniere's disease: is there a link?","volume":"59","author":"Radtke","year":"2002","journal-title":"Neurology."},{"key":"B4","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1002\/lary.25344","article-title":"Migraine features in patients with Meniere's disease","volume":"126","author":"Ghavami","year":"2016","journal-title":"Laryngoscope."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.3109\/00016489.2014.939300","article-title":"Caloric stimulation and video-head impulse testing in Meniere's disease and vestibular migraine","volume":"134","author":"Blodow","year":"2014","journal-title":"Acta Otolaryngol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1177\/0194599811434073","article-title":"Can vestibular-evoked myogenic potentials help differentiate Meniere disease from vestibular migraine?","volume":"146","author":"Zuniga","year":"2012","journal-title":"Otolaryngol Head Neck Surg."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.3389\/fimmu.2019.01229","article-title":"Differential proinflammatory signature in vestibular migraine and Meniere disease","volume":"10","author":"Flook","year":"2019","journal-title":"Front Immunol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2931","DOI":"10.1007\/s00405-015-3835-y","article-title":"Comparison of linear motion perception thresholds in vestibular migraine and Meniere's disease","volume":"273","author":"Bremova","year":"2016","journal-title":"Eur Arch Otorhinolaryngol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2382","DOI":"10.1002\/lary.26518","article-title":"Magnetic resonance imaging of intratympanic gadolinium helps differentiate vestibular migraine from Meniere disease","volume":"127","author":"Sun","year":"2017","journal-title":"Laryngoscope."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1111\/j.1468-2982.2009.01860.x","article-title":"Does migraine-associated vertigo share a common pathophysiology with Meniere's disease? 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