{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:29:18Z","timestamp":1790062158092,"version":"4.0.1"},"reference-count":78,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:00:00Z","timestamp":1651449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>In this systematic review, we aim to evaluate the evidence regarding the correlation between tinnitus distress and the severity of depressive symptoms in patients with chronic tinnitus. Also, the prevalence of clinically relevant depressive symptoms scores in patients with chronic tinnitus was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a systematic review in PubMed, EMBASE, and the Cochrane library in June 2021 using the terms \u201cdepression\u201d and \u201ctinnitus,\u201d and their synonyms, following PRISMA guidelines. Studies were selected on relevance and critically appraised regarding risk of bias using the Newcastle\u2013Ottowa Quality Assessment Scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1,912 articles were screened on title and abstract after the removal of the duplicates. Eventually, 33 (1.5%) articles were included for the final analysis. Only cross-sectional cohort studies and case\u2013control studies with a low level of evidence and a high risk of bias due to the study design and patient selection were found. Statistically significant correlations between the experienced tinnitus distress and depressive symptoms were reported in 31 out of 33 studies. Clinically relevant depression scores had a prevalence of 4.6\u201341.7%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this systematic review, in which mostly cross-sectional studies were included, a statistically significant correlation was found between the experienced tinnitus distress and the reported severity of symptoms of depression in patients with chronic tinnitus. A wide range of clinically relevant depression scores were reported in included studies. Due to the high risk of bias of included studies it is not possible to provide a definite answer on the existence of this relationship. Future population-based studies are necessary to provide more clarity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2022.870433","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T01:43:19Z","timestamp":1651455799000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Correlation Between Chronic Tinnitus Distress and Symptoms of Depression: A Systematic Review"],"prefix":"10.3389","volume":"13","author":[{"given":"Sebastiaan M.","family":"Meijers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maaike","family":"Rademaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rutger L.","family":"Meijers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Stegeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana L.","family":"Smit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/S0030-6665(02)00160-3","article-title":"Classification and epidemiology of tinnitus","volume":"36","author":"Heller","year":"2003","journal-title":"Otolaryngol Clin North Am."},{"key":"B2","doi-asserted-by":"publisher","first-page":"802","DOI":"10.3389\/fnins.2019.00802","article-title":"Why is there no cure for tinnitus?","volume":"13","author":"McFerran","year":"2019","journal-title":"Front Neurosci."},{"key":"B3","article-title":"Prevalence of sleep impairment in patients with tinnitus: a systematic review and single-arm meta-analysis","volume-title":"Eur Arch otorhinolaryngol.","author":"Gu","year":"2021"},{"key":"B4","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1177\/0194599820957296","article-title":"Prevalence of tinnitus in an aging population and its relation to age and hearing loss","volume":"164","author":"Oosterloo","year":"2021","journal-title":"Otolaryngol neck Surg."},{"key":"B5","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1080\/00016489.2021.1876919","article-title":"Association between hearing status and tinnitus distress","volume":"141","author":"Waechter","year":"2021","journal-title":"Acta Otolaryngol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3988\/jcn.2021.17.1.1","article-title":"Tinnitus update","volume":"17","author":"Han","year":"2021","journal-title":"J Clin Neurol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.cpr.2017.12.006","article-title":"A systematic review and meta-analysis of psychological functioning in chronic tinnitus","volume":"60","author":"Trevis","year":"2018","journal-title":"Clin Psychol Rev."},{"key":"B8","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/0163-8343(88)90037-0","article-title":"Disabling tinnitus. 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