{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:10:10Z","timestamp":1788365410410,"version":"build-2803163510"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the contribution of duration and temporal dispersion (TD) of the distal compound muscle action potential (CMAP) in discriminating chronic inflammatory demyelinating polyneuropathy (CIDP) from diabetic sensorimotor polyneuropathy (DSP) and from CIDP+DSP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective review of patients diagnosed with CIDP, DSP and CIDP+DSP (responsive to immunotherapy) and examined differences in CMAP duration and TD at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 59 subjects: 17 CIDP, 21 DSP and 21 CIDP+DSP. Of these, 16 (94.1%) CIDP, 18 (85.7%) CIDP+DSP and 1 (4.7%) DSP fulfilled the 2010 EFNS\/PNS criteria for definite CIDP. There was no difference in CMAP duration or TD in all nerves (compound outcome) or in individual motor nerves. Patients with CIDP\/CIDP+DSP had more conduction blocks, slower conduction velocities and more prolonged F wave latencies than those with DSP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Measures of CMAP duration and TD were not helpful in distinguishing CIDP, DSP or CIDP+DSP patients; however, parameters such as F-wave latencies, conduction blocks or the number of demyelinating parameters were useful in this separation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>There are no definite nerve conduction criteria to distinguish patients with CIDP+DSP from DSP alone. Further studies focusing on measures of demyelination may provide stronger evidence to guide treatment decisions in CIDP + DSP patients.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2022.872762","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T09:04:54Z","timestamp":1650963894000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Temporal Dispersion and Duration of the Distal Compound Muscle Action Potential Do Not Distinguish Diabetic Sensorimotor Polyneuropathy From Chronic Inflammatory Demyelinating Polyneuropathy"],"prefix":"10.3389","volume":"13","author":[{"given":"Monica","family":"Alcantara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mylan","family":"Ngo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"de la Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Menon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Barnett-Tapia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Katzberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Bril","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"136","DOI":"10.2337\/dc16-2042","article-title":"Diabetic neuropathy: a position statement by the American diabetes association","volume":"40","author":"Pop-Busui","year":"2017","journal-title":"Diabetes Care."},{"key":"B2","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1002\/mus.27014","article-title":"Diabetic neuropathies","volume":"63","author":"Patel","year":"2021","journal-title":"Muscle Nerve."},{"key":"B3","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1055\/s-0035-1558972","article-title":"Diabetic neuropathies","volume":"35","author":"Izenberg","year":"2015","journal-title":"Semin Neurol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1002\/dmrr.1226","article-title":"Diabetic polyneuropathies: update on research definition, diagnostic criteria and estimation of severity","volume":"27","author":"Dyck","year":"2011","journal-title":"Diabetes Metab Res Rev."},{"key":"B5","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/nrneurol.2017.123","article-title":"CIDP and other inflammatory neuropathies in diabetes - diagnosis and management","volume":"13","author":"Rajabally","year":"2017","journal-title":"Nat Rev Neurol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1002\/brb3.177","article-title":"Comparison of diabetes patients with \u201cdemyelinating\u201d diabetic sensorimotor polyneuropathy to those diagnosed with CIDP","volume":"3","author":"Dunnigan","year":"2013","journal-title":"Brain Behav."},{"key":"B7","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1136\/jnnp-2019-320314","article-title":"Chronic inflammatory demyelinating polyneuropathy: update on diagnosis, immunopathogenesis and treatment","volume":"90","author":"Lehmann","year":"2019","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"B8","doi-asserted-by":"publisher","first-page":"3684","DOI":"10.2337\/dc13-0746","article-title":"Conduction slowing in diabetic sensorimotor polyneuropathy","volume":"36","author":"Dunnigan","year":"2013","journal-title":"Diabetes Care."},{"key":"B9","doi-asserted-by":"publisher","first-page":"e89344","DOI":"10.1371\/journal.pone.0089344","article-title":"The characteristics of chronic inflammatory demyelinating polyneuropathy in patients with and without diabetes\u2013an observational study","volume":"9","author":"Dunnigan","year":"2014","journal-title":"PLoS ONE."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1016\/j.jdiacomp.2016.05.007","article-title":"The dilemma of diabetes in chronic inflammatory demyelinating polyneuropathy","volume":"30","author":"Bril","year":"2016","journal-title":"J Diabetes Complications."},{"key":"B11","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1212\/WNL.0b013e3181aaea47","article-title":"Incidence and prevalence of CIDP and the association of diabetes mellitus","volume":"73","author":"Laughlin","year":"2009","journal-title":"Neurology."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1136\/jnnp-2020-323615","article-title":"Frequency of diabetes and other comorbidities in chronic inflammatory demyelinating polyradiculoneuropathy and their impact on clinical presentation and response to therapy","volume":"91","author":"Doneddu","year":"2020","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"B13","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1007\/s004150200066","article-title":"Symptomatic diabetic and non-diabetic neuropathies in a series of 100 diabetic patients","volume":"249","author":"Lozeron","year":"2002","journal-title":"J Neurol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/s11892-004-0048-y","article-title":"Chronic inflammatory demyelinating polyradiculoneuropathy in diabetes mellitus","volume":"4","author":"Ayyar","year":"2004","journal-title":"Curr Diab Rep."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1136\/jnnp-2020-322971","article-title":"Chronic inflammatory demyelinating polyneuropathy associated with diabetes: a European multicentre comparative reappraisal","volume":"91","author":"Rajabally","year":"2020","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"B16","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.jns.2016.11.056","article-title":"Clinical characteristics, and impairment and disability scale scores for different CIDP Disease Activity Status classes","volume":"372","author":"Alabdali","year":"2017","journal-title":"J Neurol Sci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1136\/jnnp-2014-308452","article-title":"Different electrophysiological profiles and treatment response in 'typical' and 'atypical' chronic inflammatory demyelinating polyneuropathy","volume":"86","author":"Kuwabara","year":"2015","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"B18","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1111\/j.1468-1331.2011.03605.x","article-title":"A European multicentre reappraisal of distal compound muscle action potential duration in chronic inflammatory demyelinating polyneuropathy","volume":"19","author":"Rajabally","year":"2012","journal-title":"Eur J Neurol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1002\/mus.20600","article-title":"Dispersion of compound muscle action potential in hereditary neuropathies and chronic inflammatory demyelinating polyneuropathy","volume":"34","author":"Stanton","year":"2006","journal-title":"Muscle Nerve."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1212\/01.WNL.0000034172.47882.20","article-title":"Dispersion of the distal compound muscle action potential as a diagnostic criterion for chronic inflammatory demyelinating polyneuropathy","volume":"59","author":"Thaisetthawatkul","year":"2002","journal-title":"Neurology."},{"key":"B21","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/S1388-2457(98)00028-5","article-title":"Chronic inflammatory demyelinating polyneuropathy in diabetics: motor conductions are important in the differential diagnosis with diabetic polyneuropathy","volume":"110","author":"Uncini","year":"1999","journal-title":"Clin Neurophysiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"e0139674","DOI":"10.1371\/journal.pone.0139674","article-title":"Treatment responsiveness in CIDP patients with diabetes is associated with higher degrees of demyelination","volume":"10","author":"Abraham","year":"2015","journal-title":"PLoS ONE."},{"key":"B23","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1586\/1744666X.2015.1018891","article-title":"Treatment responsiveness in CIDP patients with diabetes is associated with unique electrophysiological characteristics, and not with common criteria for CIDP","volume":"11","author":"Abraham","year":"2015","journal-title":"Expert Rev Clin Immunol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1002\/mus.21186","article-title":"Sensory nerve conduction slowing is a specific marker for CIDP","volume":"38","author":"Bragg","year":"2008","journal-title":"Muscle Nerve."},{"key":"B25","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.clinph.2020.09.001","article-title":"Electrophysiological testing in chronic inflammatory demyelinating polyneuropathy patients treated with subcutaneous immunoglobulin: the polyneuropathy and treatment with hizentra (PATH) study","volume":"132","author":"Bril","year":"2021","journal-title":"Clin Neurophysiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"27","DOI":"10.17161\/rrnmf.v2i3.15250","article-title":"Duration and temporal dispersion measurements in CIDP subjects from the Polyneuropathy And Treatment with Hizentra (PATH) study","volume":"2","author":"Menon","year":"2021","journal-title":"RRNMF Neuromusc J."},{"key":"B27","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1111\/j.1468-1331.2009.02930.x","article-title":"European federation of neurological societies\/peripheral nerve society guideline on management of chronic inflammatory demyelinating polyradiculoneuropathy: report of a joint task force of the european federation of neurological societies and the peripheral nerve society - first revision","volume":"17","author":"Van den Bergh","year":"2010","journal-title":"Eur J Neurol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1111\/j.1529-8027.2009.00226.x","article-title":"Utility of the distal compound muscle action potential duration for diagnosis of demyelinating neuropathies","volume":"14","author":"Isose","year":"2009","journal-title":"J Peripher Nerv Syst."},{"key":"B29","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1111\/jns.12455","article-title":"European academy of neurology\/peripheral nerve society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: report of a joint task force-second revision","volume":"26","author":"Van den Bergh","year":"2021","journal-title":"J Peripher Nerv Syst"},{"key":"B30","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.clinph.2012.05.019","article-title":"Practical electrodiagnostic value of F-wave studies in chronic inflammatory demyelinating polyneuropathy","volume":"124","author":"Rajabally","year":"2013","journal-title":"Clin Neurophysiol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1007\/s00415-020-10287-7","article-title":"Underdiagnosis and diagnostic delay in chronic inflammatory demyelinating polyneuropathy","volume":"268","author":"Chaudhary","year":"2021","journal-title":"J Neurol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.2337\/diacare.27.2007.S5","article-title":"Diagnosis and classification of diabetes mellitus","volume":"27","author":"Association","year":"2004","journal-title":"Diabetes Care."},{"key":"B33","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1212\/WNL.0b013e318208824b","article-title":"Rasch-built overall disability scale (R-ODS) for immune-mediated peripheral neuropathies","volume":"76","author":"van Nes","year":"2011","journal-title":"Neurology."},{"key":"B34","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1136\/jnnp.2005.081547","article-title":"A modified peripheral neuropathy scale: the overall neuropathy limitations scale","volume":"77","author":"Graham","year":"2006","journal-title":"J Neurol Neurosurg Psychiatry."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2022.872762\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T09:04:59Z","timestamp":1650963899000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2022.872762\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,26]]},"references-count":34,"alternative-id":["10.3389\/fneur.2022.872762"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2022.872762","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,26]]},"article-number":"872762"}}