{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T10:54:25Z","timestamp":1778237665124,"version":"3.51.4"},"reference-count":52,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T00:00:00Z","timestamp":1655337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>Some patients with primary progressive aphasia (PPA) present with various types of hearing deficits. Research on the auditory function and speech sounds in PPA, including temporal, phonemic, and prosodic processing, revealed impairment in some of these auditory processes. Many patients with PPA who present with impaired word recognition subsequently developed non-fluent variant PPA. Herein, we present a patient with semantic variant PPA (svPPA) who demonstrated impaired verbal word discrimination. Audiological examinations revealed normal auditory brainstem responses and slightly impaired pure-tone perception. By contrast, verbal word discrimination and monosyllable identification were impaired, and temporal auditory acuity deteriorated. Analyses of brain magnetic resonance images revealed a significant decrease in the gray matter volume in bilateral superior temporal areas, predominantly on the left, compared with those of patients with typical svPPA, which appeared to be associated with impaired word recognition in our patient.<\/jats:p>","DOI":"10.3389\/fneur.2022.873735","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T05:51:20Z","timestamp":1655358680000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Case Report: Semantic Variant Primary Progressive Aphasia With Impaired Verbal Word Discrimination"],"prefix":"10.3389","volume":"13","author":[{"given":"Nobuko","family":"Kawakami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumi","family":"Morita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigenori","family":"Kanno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanayo","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Kakinuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumiko","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erena","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Narita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1212\/WNL.0b013e31821103e6","article-title":"Classification of primary progressive aphasia and its variants","volume":"76","author":"Gorno-Tempini","year":"2011","journal-title":"Neurology."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1093\/brain\/aws080","article-title":"Quantitative classification of primary progressive aphasia at early and mild impairment stages","volume":"135","author":"Mesulam","year":"2012","journal-title":"Brain."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1804","DOI":"10.1212\/WNL.0b013e31821ccd3c","article-title":"Progression of language decline and cortical atrophy in subtypes of primary progressive aphasia","volume":"76","author":"Rogalski","year":"2011","journal-title":"Neurology."},{"key":"B4","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1097\/WCO.0000000000000673","article-title":"Primary progressive aphasia: a model for neurodegenerative disease","volume":"32","author":"Tee","year":"2019","journal-title":"Curr Opin Neurol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s11910-021-01097-z","article-title":"Primary progressive aphasia: toward a pathophysiological synthesis","volume":"21","author":"Ruksenaite","year":"2021","journal-title":"Curr Neurol Neurosci Rep."},{"key":"B6","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1159\/000007923","article-title":"Slowly progressive pure word deafness","volume":"39","author":"Otsuki","year":"1998","journal-title":"Eur Neurol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1080\/00016480310015975","article-title":"A case of cortical deafness and anarthria","volume":"124","author":"Kaga","year":"2004","journal-title":"Acta Otolaryngol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1111\/j.1468-1331.2007.01671.x","article-title":"Pure word deafness and pure anarthria in a patient with frontotemporal dementia","volume":"14","author":"Iizuka","year":"2007","journal-title":"Eur J Neurol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"227","DOI":"10.3988\/jcn.2011.7.4.227","article-title":"Pure word deafness in a patient with early-onset Alzheimer's disease: an unusual presentation","volume":"7","author":"Kim","year":"2011","journal-title":"J Clin Neurol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1155\/2012\/264927","article-title":"Augmented input reveals word deafness in a man with frontotemporal dementia","volume":"25","author":"Gibbons","year":"2012","journal-title":"Behav Neurol."},{"key":"B11","unstructured":"case of slowly progressive aphasia with auditory agnosia299303\n            KuramotoS\n            HiranoT\n            UyamaE\n            TokisatoK\n            MiuraM\n            WatanabeS\n          12561084Clin Neurol.422002"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e519","DOI":"10.3389\/fneur.2020.00519","article-title":"Non-fluent\/agrammatic variant of primary progressive aphasia with generalized auditory agnosia","volume":"11","author":"Watanabe","year":"2020","journal-title":"Front Neurol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.pscychresns.2005.12.003","article-title":"Primary progressive aphasia accompanied by environmental sound agnosia: a neuropsychological, MRI and PET study","volume":"146","author":"Uttner","year":"2006","journal-title":"Psychiatry Res."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1002\/acn3.51101","article-title":"Impaired phonemic discrimination in logopenic variant primary progressive aphasia","volume":"7","author":"Johnson","year":"2020","journal-title":"Ann Clin Transl Neurol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s13195-017-0278-2","article-title":"Behavioral and neuroanatomical correlates of auditory speech analysis in primary progressive aphasias","volume":"9","author":"Hardy","year":"2017","journal-title":"Alzheimers Res Ther."},{"key":"B16","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.neurobiolaging.2017.04.026","article-title":"Functional neuroanatomy of speech signal decoding in primary progressive aphasias","volume":"56","author":"Hardy","year":"2017","journal-title":"Neurobiol Aging."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1016\/S0028-3932(00)00034-8","article-title":"Non-verbal semantic impairment in semantic dementia","volume":"38","author":"Bozeat","year":"2000","journal-title":"Neuropsychologia."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1093\/brain\/awl069","article-title":"Lost in semantic space: a multi-modal, non-verbal assessment of feature knowledge in semantic dementia","volume":"129","author":"Garrard","year":"2006","journal-title":"Brain."},{"key":"B19","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.jns.2015.03.007","article-title":"Identification of environmental sounds and melodies in syndromes of anterior temporal lobe degeneration","volume":"352","author":"Golden","year":"2015","journal-title":"J Neurol Sci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/j.neuropsychologia.2008.12.030","article-title":"The association between semantic dementia and surface dyslexia in Japanese","volume":"47","author":"Fushimi","year":"2009","journal-title":"Neuropsychologia."},{"key":"B21","doi-asserted-by":"publisher","first-page":"153","DOI":"10.2496\/apr.12.153","article-title":"Gogi (word meaning) aphasia and semantic memory for words","volume":"12","author":"Tanabe","year":"1992","journal-title":"Higher Brain Function Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1212\/WNL.25.7.627","article-title":"The syndrome of Gogi (word meaning) aphasia. Selective impairment of kanji processing","volume":"25","author":"Sasanuma","year":"1975","journal-title":"Neurology."},{"key":"B23","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1093\/brain\/97.1.373","article-title":"Time to understand. A case study of word deafness with reference to the role of time in auditory comprehension","volume":"97","author":"Albert","year":"1957","journal-title":"Brain."},{"key":"B24","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1093\/brain\/105.2.271","article-title":"Pure word deafness. Analysis of a case with bilateral lesions and a defect at the prephonemic level","volume":"105","author":"Auerbach","year":"1982","journal-title":"Brain."},{"key":"B25","unstructured":"The method of speech audiometry62237Audiology462003"},{"key":"B26","unstructured":"CAT-A Computational Anatomy Toolbox for the Analysis of Structual MRI Data HBM\n            Christian GaserRD\n          2016"},{"key":"B27","doi-asserted-by":"publisher","first-page":"e207","DOI":"10.3389\/fnagi.2016.00207","article-title":"Anatomical correlates of non-verbal perception in dementia patients","volume":"8","author":"Lin","year":"2016","journal-title":"Front Aging Neurosci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.cortex.2017.10.006","article-title":"Pure word deafness following left temporal damage: behavioral and neuroanatomical evidence from a new case","volume":"97","author":"Maffei","year":"2017","journal-title":"Cortex."},{"key":"B29","doi-asserted-by":"publisher","first-page":"104677","DOI":"10.1016\/j.bandl.2019.104677","article-title":"Neural processing critical for distinguishing between speech sounds","volume":"197","author":"Kim","year":"2019","journal-title":"Brain Lang."},{"key":"B30","unstructured":"[Performance evaluation of phosphorylated tau protein kit \u201cFainoscalar pTAU\u201d] Rinsanka tau tanpaku kitto \u201cfeinosukara pTAU\u201d no seinou hyouka (in Japanese)7137\n            AraiH\n            YoshidaH\n          J Clin Lab Instrum Reag.362013"},{"key":"B31","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1001\/archneur.1984.04050170037012","article-title":"Language disturbance. An initial symptom of cortical degenerations and dementia","volume":"41","author":"Kirshner","year":"1984","journal-title":"Arch Neurol."},{"key":"B32","unstructured":"A case of neurodegenerative disease presenting with primary progressive hearing loss and logoclonia5461\n            LeeYAE\n            IshiaiS\n            WatabikiS\n            TakahashiM\n          JPN J Neuropsychol.172001"},{"key":"B33","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1080\/13554790802363738","article-title":"Word deafness as a cortical auditory processing deficit: a case report with MEG","volume":"14","author":"J\u00f6rgens","year":"2008","journal-title":"Neurocase."},{"key":"B34","doi-asserted-by":"publisher","first-page":"361","DOI":"10.20584\/neuropsychology.32.4_361","article-title":"case of progressive word deafness and foreign accent syndrome","volume":"32","author":"Ota","year":"2016","journal-title":"JPN J Neuropsychol."},{"key":"B35","first-page":"74","volume":"28","author":"Satoh","year":"2017","journal-title":"JPN J Geriatr Psychiatry."},{"key":"B36","unstructured":"[Evaluation rehabilitation of primary progressive aphasia. A case report of Apraxia of speech, pure word deafness amusia] Genpatsusei shinkousei shitsugo no hyouka to rihabiritesyon (in Japanese)53845\n            SatoM\n          J JPN Soc Dement Care172018"},{"key":"B37","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.cortex.2019.01.021","article-title":"Prominent auditory deficits in primary progressive aphasia: a case study","volume":"117","author":"Utianski","year":"2019","journal-title":"Cortex."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2007.01899.x","article-title":"Letter to IIzuka-pure word deafness and frontotemporal dementia","author":"Boban","year":"2007","journal-title":"Eur J Neurol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1093\/brain\/110.2.381","article-title":"Pure word deafness following bilateral lesions - a psychophysical analysis","volume":"110","author":"Tanaka","year":"1987","journal-title":"Brain."},{"key":"B40","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/nrn2113","article-title":"The cortical organization of speech processing","volume":"8","author":"Hickok","year":"2007","journal-title":"Nat Rev Neurosci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1080\/01690965.2013.834370","article-title":"The architecture of speech production and the role of the phoneme in speech processing","volume":"29","author":"Hickok","year":"2014","journal-title":"Lang Cogn Processes."},{"key":"B42","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1162\/jocn_a_00901","article-title":"Phonological processing in primary progressive aphasia","volume":"28","author":"Henry","year":"2016","journal-title":"J Cogn Neurosci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bandl.2010.03.008","article-title":"Localization of sublexical speech perception components","volume":"114","author":"Turkeltaub","year":"2010","journal-title":"Brain Lang."},{"key":"B44","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s13195-016-0219-5","article-title":"An update on semantic dementia: genetics, imaging, and pathology","volume":"8","author":"Landin-Romero","year":"2016","journal-title":"Alzheimers Res Ther."},{"key":"B45","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1080\/13554790903193174","article-title":"Alzheimer's disease neuropathologic changes in semantic dementia","volume":"16","author":"Chow","year":"2010","journal-title":"Neurocase."},{"key":"B46","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1136\/jnnp-2013-306948","article-title":"New criteria for frontotemporal dementia syndromes: clinical and pathological diagnostic implications","volume":"85","author":"Chare","year":"2014","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"B47","first-page":"28","volume":"22","author":"Kawakatsu","year":"2011","journal-title":"JPN J Geriatr Psychiatry."},{"key":"B48","doi-asserted-by":"publisher","first-page":"153","DOI":"10.12659\/AJCR.907799","article-title":"Posterior associative and cingulate cortex involvement of Brain single-photon emission computed tomography (SPECT) imaging in semantic dementia with probable Alzheimer's disease pathology: a case report","volume":"19","author":"Takano","year":"2018","journal-title":"Am J Case Rep."},{"key":"B49","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3233\/JAD-180087","article-title":"Parietal involvement in the semantic variant of primary progressive aphasia with Alzheimer's disease cerebrospinal fluid profile","volume":"66","author":"Bera","year":"2018","journal-title":"J Alzheimers Dis."},{"key":"B50","doi-asserted-by":"publisher","first-page":"2339","DOI":"10.1007\/s00415-016-8208-y","article-title":"Hearing and dementia","volume":"263","author":"Hardy","year":"2016","journal-title":"J Neurol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1093\/brain\/awg082","article-title":"Neural resources for processing language and environmental sounds: evidence from aphasia","volume":"126","author":"Saygin","year":"2003","journal-title":"Brain."},{"key":"B52","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s00702-005-0342-0","article-title":"Functional neuroanatomy of non-verbal semantic sound processing in humans","volume":"113","author":"Engelien","year":"2006","journal-title":"J Neural Transm."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2022.873735\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T05:51:27Z","timestamp":1655358687000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2022.873735\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,16]]},"references-count":52,"alternative-id":["10.3389\/fneur.2022.873735"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2022.873735","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,16]]},"article-number":"873735"}}