{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:28:32Z","timestamp":1785796112861,"version":"3.56.0"},"reference-count":82,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T00:00:00Z","timestamp":1654128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Systemic, low-grade immune\u2013inflammatory activity, together with social and neurocognitive performance deficits are a transdiagnostic trait of people suffering from type 2 diabetes mellitus (T2DM) and severe mental illnesses (SMIs), such as schizophrenia (SZ), major depressive disorder (MDD), and bipolar disorder (BD). We aimed to determine if immune\u2013inflammatory mediators were significantly altered in people with SMIs or T2DM compared with healthy controls (HC) and whether these biomarkers could help predict their cognition and social functioning 1 year after assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a prospective, 1-year follow-up cohort study with 165 participants at baseline (TB), including 30 with SZ, 42 with BD, 35 with MDD, 30 with T2DM, and 28 HC; and 125 at 1-year follow-up (TY), and determined executive domain (ED), global social functioning score (GSFS), and peripheral blood immune\u2013inflammatory and oxidative stress biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants with SMIs and T2DM showed increased peripheral levels of inflammatory markers, such as interleukin-10 (<jats:italic>p<\/jats:italic> &amp;lt; 0.01; \u03b7<jats:sup>2<\/jats:sup><jats:italic>p<\/jats:italic> = 0.07) and tumor necrosis factor-\u03b1 (<jats:italic>p<\/jats:italic> &amp;lt; 0.05; \u03b7<jats:sup>2<\/jats:sup><jats:italic>p<\/jats:italic> = 0.08); and oxidative stress biomarkers, such as reactive oxygen species (ROS) (<jats:italic>p<\/jats:italic> &amp;lt; 0.05; \u03b7<jats:sup>2<\/jats:sup><jats:italic>p<\/jats:italic> = 0.07) and mitochondrial ROS (<jats:italic>p<\/jats:italic> &amp;lt; 0.01; \u03b7<jats:sup>2<\/jats:sup><jats:italic>p<\/jats:italic> = 0.08). The different combinations of the exposed biomarkers anticipated 46\u201357.3% of the total ED and 23.8\u201335.7% of GSFS for the participants with SMIs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations<\/jats:title><jats:p>Participants' treatment, as usual, was continued without no specific interventions; thus, it was difficult to anticipate substantial changes related to the psychopharmacological pattern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>People with SMIs show significantly increased levels of peripheral immune\u2013inflammatory biomarkers, which may contribute to the neurocognitive and social deficits observed in SMIs, T2DM, and other diseases with systemic immune\u2013inflammatory activation of chronic development. These parameters could help identify the subset of patients who could benefit from immune\u2013inflammatory modulator strategies to ameliorate their functional outcomes.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2022.883927","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T06:09:31Z","timestamp":1654150171000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":30,"title":["Immune\u2013Inflammatory Biomarkers Predict Cognition and Social Functioning in Patients With Type 2 Diabetes Mellitus, Major Depressive Disorder, Bipolar Disorder, and Schizophrenia: A 1-Year Follow-Up Study"],"prefix":"10.3389","volume":"13","author":[{"given":"Marta","family":"Gar\u00e9s-Caballer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan Vicent","family":"S\u00e1nchez-Ort\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Correa-Ghisays","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicent","family":"Balanz\u00e1-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Selva-Vera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Vila-Franc\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Magdalena-Benedito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constanza","family":"San-Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor M.","family":"Victor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Escribano-Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Hernandez-Mijares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Vivas-Lalinde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Vieta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan C.","family":"Leza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Tabar\u00e9s-Seisdedos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbi.2016.01.017","article-title":"Chronic peripheral inflammation, hippocampal neurogenesis, and behavior","volume":"58","author":"Chesnokova","year":"2016","journal-title":"Brain Behav Immun."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1017\/S0033291719001685","article-title":"Peripheral inflammatory and neurotrophic biomarkers of cognitive impairment in schizophrenia: a meta-analysis","volume":"49","author":"Bora","year":"2019","journal-title":"Psychol Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1016\/S0140-6736(20)30752-2","article-title":"Global burden of 87 risk factors in 204 countries and territories, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"396","year":"2020","journal-title":"Lancet"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.1017\/S0033291719001454","article-title":"Prevalence of low-grade inflammation in depression: a systematic review and meta-analysis of CRP levels","volume":"49","author":"Osimo","year":"2019","journal-title":"Psychol Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.rcp.2017.01.004","article-title":"Inflammatory markers in the staging of bipolar disorder: a systematic review of the literature","volume":"47","author":"Casta\u00f1o-Ram\u00edrez","year":"2018","journal-title":"Rev Colomb Psiquiatr."},{"key":"B6","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.pnpbp.2018.03.012","article-title":"Neutrophil\/lymphocyte ratio and platelet\/lymphocyte ratio in mood disorders: a meta-analysis","volume":"84","author":"Mazza","year":"2018","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry."},{"key":"B7","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.jad.2015.08.058","article-title":"McIntyre RS. Inflammation as a neurobiological substrate of cognitive impairment in bipolar disorder: evidence, pathophysiology and treatment implications","volume":"188","author":"Rosenblat","year":"2015","journal-title":"J Affect Disord."},{"key":"B8","doi-asserted-by":"publisher","first-page":"583","DOI":"10.2174\/1570159X16666180119144538","article-title":"Protein-C reactive as biomarker predictor of schizophrenia phases of illness? A systematic review","volume":"16","author":"Orsolini","year":"2018","journal-title":"Curr Neuropharmacol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1007\/s12325-016-0455-x","article-title":"McIntyre RS. Sirukumab: a potential treatment for mood disorders?","volume":"34","author":"Zhou","year":"2017","journal-title":"Adv Ther."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2229","DOI":"10.1017\/S0033291717000745","article-title":"Immunopsychiatry: important facts","volume":"47","author":"Khandaker","year":"2017","journal-title":"Psychol Med."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.schres.2017.04.015","article-title":"Cytokines and C-reactive protein alterations with respect to cognitive impairment in schizophrenia and bipolar disorder: a systematic review","volume":"192","author":"Misiak","year":"2018","journal-title":"Schizophr Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1093\/schbul\/sbr148","article-title":"Prevalence of metabolic syndrome and metabolic abnormalities in schizophrenia and related disorders\u2013a systematic review and meta-analysis","volume":"39","author":"Mitchell","year":"2013","journal-title":"Schizophr Bull"},{"key":"B13","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.jpsychires.2017.03.018","article-title":"A systematic review of evidence for the role of inflammatory biomarkers in bipolar patients","volume":"92","author":"Sayana","year":"2017","journal-title":"J Psychiatr Res."},{"key":"B14","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.bbi.2018.06.016","article-title":"Replication and reproducibility issues in the relationship between C-reactive protein and depression: a systematic review and focused meta-analysis","volume":"73","author":"Horn","year":"2018","journal-title":"Brain Behav Immun."},{"key":"B15","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.neuroscience.2009.03.080","article-title":"The genetics of bipolar disorder","volume":"164","author":"Barnett","year":"2009","journal-title":"Neuroscience."},{"key":"B16","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1093\/ijnp\/pyu037","article-title":"FLAMM-PEPs study, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Spain. Pro-\/antiinflammatory dysregulation in early psychosis: results from a 1-year follow-up study","volume":"31","author":"Garc\u00eda-Bueno","year":"2014","journal-title":"Int J Neuropsychopharmacol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.eurpsy.2017.09.007","article-title":"de la Fuente-Tomas L, Gonz\u00e1lez-Blanco L, S\u00e1iz-Mart\u00ednez P, et al. Regulation of inflammatory pathways in schizophrenia: A comparative study with bipolar disorder and healthy controls","volume":"47","author":"Garc\u00eda-\u00c1lvarez","year":"2018","journal-title":"Eur Psychiatry."},{"key":"B18","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1017\/S1092852918001499","article-title":"Neuroinflammation and cognition across psychiatric conditions","volume":"24","author":"Fourrier","year":"2019","journal-title":"CNS Spectr."},{"key":"B19","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/s11892-013-0375-y","article-title":"Diabetes mellitus and inflammation","volume":"13","author":"Lontchi-Yimagou","year":"2013","journal-title":"Curr Diab Rep."},{"key":"B20","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1155\/2014\/102158","article-title":"Diabetes and the brain: oxidative stress, inflammation, and autophagy","volume":"102","author":"Muriach","year":"2014","journal-title":"Oxid Med Cell Longev."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.bbadis.2016.04.017","article-title":"Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease","volume":"1863","author":"Pugazhenthi","year":"2017","journal-title":"Biochim Biophys Acta Mol Basis Dis."},{"key":"B22","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/bdi.12821","article-title":"Current understandings of the trajectory and emerging correlates of cognitive impairment in bipolar disorder: an overview of evidence","volume":"22","author":"Van Rheenen","year":"2020","journal-title":"Bipolar Disord."},{"key":"B23","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.bbi.2020.09.011","article-title":"Inflammatory and cardiometabolic markers at presentation with first episode psychosis and long-term clinical outcomes: a longitudinal study using electronic health records","volume":"91","author":"Osimo","year":"2021","journal-title":"Brain Behav Immun."},{"key":"B24","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/mp.2016.167","article-title":"Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions","volume":"23","author":"Kappelmann","year":"2018","journal-title":"Mol Psychiatry."},{"key":"B25","doi-asserted-by":"publisher","first-page":"4195","DOI":"10.1007\/s12035-017-0632-1","article-title":"Peripheral alterations in cytokine and chemokine levels after antidepressant drug treatment for major depressive disorder: systematic review and meta-analysis","volume":"55","author":"K\u00f6hler","year":"2018","journal-title":"Mol Neurobiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"19","DOI":"10.2174\/1871527317666181105162347","article-title":"Efficacy of celecoxib adjunct treatment on bipolar disorder: systematic review and meta-analysis","volume":"18","author":"Bavaresco","year":"2019","journal-title":"CNS Neurol Disord Drug Targets."},{"key":"B27","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s12974-020-1721-z","article-title":"Effects of inflammation on the kynurenine pathway in schizophrenia - a systematic review","volume":"17","author":"Pedraz-Petrozzi","year":"2020","journal-title":"J Neuroinflammation."},{"key":"B28","doi-asserted-by":"publisher","first-page":"46","DOI":"10.24869\/psyd.2020.46","article-title":"A meta-analysis of abnormal glucose metabolism in first-episode drug-naive schizophrenia","volume":"32","author":"Yang","year":"2020","journal-title":"Psychiatr Danub."},{"key":"B29","doi-asserted-by":"publisher","first-page":"227","DOI":"10.31887\/DCNS.2019.21.3\/pharvey","article-title":"Domains of cognition and their assessment","volume":"21","author":"Harvey","year":"2019","journal-title":"Dialogues Clin Neurosci."},{"key":"B30","doi-asserted-by":"publisher","first-page":"75","DOI":"10.33588\/rn.6402.2016227","article-title":"un modelo de funciones ejecutivas basado en an\u00e1lisis factoriales","volume":"64","author":"Tirapu-Ust\u00e1rroz","year":"2017","journal-title":"Rev Neurol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/14651858.CD012116.pub2","article-title":"Acetylsalicylic acid (aspirin) for schizophrenia","volume":"8","author":"Schmidt","year":"2019","journal-title":"Cochrane Database Syst Rev."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/tp.2016.261","article-title":"The genetic overlap between mood disorders and cardiometabolic diseases: a systematic review of genome wide and candidate gene studies","volume":"7","author":"Amare","year":"2017","journal-title":"Transl Psychiatry."},{"key":"B33","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.jpsychires.2017.04.004","article-title":"Adjunctive celecoxib for schizophrenia: a meta-analysis of randomized, double-blind, placebo-controlled trials","volume":"92","author":"Zheng","year":"2017","journal-title":"J Psychiatr Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1111\/acps.13016","article-title":"Efficacy of anti-inflammatory treatment on major depressive disorder or depressive symptoms: meta-analysis of clinical trials","volume":"139","author":"K\u00f6hler-Forsberg","year":"2019","journal-title":"Acta Psychiatr Scand."},{"key":"B35","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.jad.2014.12.015","article-title":"Taking the fuel out of the fire: evidence for the use of anti-inflammatory agents in the treatment of bipolar disorders","volume":"174","author":"Ayorech","year":"2015","journal-title":"J Affect Disord."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1177\/0269881117725711","article-title":"Anti-inflammatory treatments for mood disorders: systematic review and meta-analysis","volume":"31","author":"Husain","year":"2017","journal-title":"J Psychopharmacol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/S2215-0366(20)30155-3","article-title":"Anti-inflammatory treatment of bipolar depression: promise and disappointment","volume":"7","author":"Berk","year":"2020","journal-title":"Lancet Psychiatry."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1093\/schbul\/sby160","article-title":"McCutcheon RA, Howes OD. A meta-analysis of immune parameters, variability, and assessment of modal distribution in psychosis and test of the immune subgroup hypothesis","volume":"45","author":"Pillinger","year":"2019","journal-title":"Schizophr Bull."},{"key":"B39","volume-title":"Manual Diagn\u00f3stico y Estad\u00edstico de los Trastornos Mentales (DSM 5) Quinta Edici\u00f3n","year":"2014"},{"key":"B40","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.2337\/diacare.28.suppl_1.S4","article-title":"Standards of medical care in diabetes","volume":"28","author":"American","year":"2005","journal-title":"Diabetes Care"},{"key":"B41","first-page":"324","article-title":"la versi\u00f3n castellana de la escala de Hamilton para la depresi\u00f3n [Validation of the Castillian version of the Hamilton Rating Scale for Depression]","volume":"14","author":"Ramos-Brieva","year":"1986","journal-title":"Actas Luso Esp Neurol Psiquiatr Cienc Afines."},{"key":"B42","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/S0025-7753(02)73419-2","article-title":"Versi\u00f3n espa\u00f1ola de una escala de evaluaci\u00f3n de la man\u00eda: validez y fiabilidad de la Escala de Young [Spanishversion of a scalefortheassessment of mania: validity and reliability of the Young Mania Rating Scale]","volume":"119","author":"Colom","year":"2002","journal-title":"Med Clin (Barc)."},{"key":"B43","first-page":"44","article-title":"la escala de los s\u00edndromes positivo y negativo (PANSS) en una muestra de esquizofr\u00e9nicos espa\u00f1oles","volume":"4","author":"Peralta","year":"1994","journal-title":"Actas Luso Esp Neurol Psiquiatr."},{"key":"B44","volume-title":"ECDEU Assessment Manual for Psychopharmacology","year":"1976"},{"key":"B45","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1745-0179-3-5","article-title":"Validity and reliability of the Functioning Assessment Short Test (FAST) in bipolar disorder","volume":"3","author":"Rosa","year":"2017","journal-title":"Clin Pract Epidemiol Ment Health."},{"key":"B46","first-page":"771","article-title":"The Spanish version of the SF-36 Health Survey (the SF-36 health questionnaire): an instrument for measuring clinical results' [Cuestionario de salud SF-36]","volume":"104","author":"Alonso","year":"1995","journal-title":"Med Clin (Barc)."},{"key":"B47","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/S0924-9338(05)80182-8","article-title":"Quality of life measures in schizophrenia","volume":"20","author":"Bobes","year":"2005","journal-title":"Eur Psychiatry."},{"key":"B48","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3389\/fpsyg.2020.525231","article-title":"Grip strength, neurocognition, and social functioning in people with type-2 diabetes mellitus, major depressive disorder, bipolar disorder, and schizophrenia","volume":"11","author":"Ali\u00f1o-Dies","year":"2020","journal-title":"Front Psychol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1159\/000083170","article-title":"Persistent cognitive dysfunctions in bipolar I disorder and schizophrenic patients: a 3-year follow-up study","volume":"74","author":"Balanz\u00e1-Mart\u00ednez","year":"2005","journal-title":"Psychother Psychosom."},{"key":"B50","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.jad.2017.03.041","article-title":"Manual motor speed dysfunction as a neurocognitive endophenotype in euthymic bipolar disorder patients and their healthy relatives. Evidence from a 5-year follow-up study","volume":"215","author":"Correa-Ghisays","year":"2017","journal-title":"J Affect Disord."},{"key":"B51","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.jad.2019.06.059","article-title":"Visual memory dysfunction as a neurocognitive endophenotype in bipolar disorder patients and their unaffected relatives. Evidence from a 5-year follow-up Valencia study","volume":"257","author":"Correa-Ghisays","year":"2019","journal-title":"J Affect Disord."},{"key":"B52","doi-asserted-by":"publisher","first-page":"184","DOI":"10.4321\/S0213-61632009000300007","article-title":"Motor speed predicts stability of cognitive deficits in both schizophrenic and bipolar I patients at one-year follow-up","volume":"23","author":"Salazar-Fraile","year":"2009","journal-title":"Eur J Psychiat."},{"key":"B53","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3390\/jcm9072154","article-title":"Motor and cognitive performance in patients with liver cirrhosis with minimal hepatic encephalopathy","volume":"9","author":"San Mart\u00edn-Valenzuela","year":"2020","journal-title":"J Clin Med."},{"key":"B54","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/1471-244X-10-47","article-title":"Correa-Ghisays, et al. The switch from conventional to atypical antipsychotic treatment should not be based exclusively on the presence of cognitive deficits A pilot study in individuals with schizophrenia","volume":"10","author":"Selva-Vera","year":"2010","journal-title":"BMC Psychiatry."},{"key":"B55","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.jad.2007.12.234","article-title":"Neurocognitive and clinical predictors of functional outcome in patients with schizophrenia and bipolar I disorder at one-year follow-up","volume":"109","author":"Tabar\u00e9s-Seisdedos","year":"2008","journal-title":"J Affect Disord."},{"key":"B56","volume-title":"Test de Colores y palabras Stroop","author":"Golden","year":"2001"},{"key":"B57","volume-title":"Test de Clasificaci\u00f3n de Tarjetas Wisconsin","author":"Grant","year":"2001"},{"key":"B58","volume-title":"Multilingual Aphasia Examination: Manual of Instructions, third ed","author":"Benton","year":"1994"},{"key":"B59","volume-title":"The Halstead-Reitan Neuropsychological Test Battery: Theory and Interpretation","author":"Reitan","year":"1985"},{"key":"B60","volume-title":"Wechsler Adult Intelligence Scale, third ed","author":"Weschler","year":"1999"},{"key":"B61","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/S0920-9964(02)00286-4","article-title":"Abnormal motor asymmetry only during bimanual movement in schizophrenic patients compared with healthy subjects","volume":"61","author":"Tabar\u00e9s-Seisdedos","year":"2003","journal-title":"Schizophr Res."},{"key":"B62","volume-title":"IBM SPSS Statistics for Windows, Version 26, 0","author":"Corp","year":"2019"},{"key":"B63","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1093\/ijnp\/pyy062","article-title":"Kinetics of cytokine levels during antipsychotic treatment in schizophrenia: a meta-analysis","volume":"21","author":"Romeo","year":"2018","journal-title":"Int J Neuropsychopharmacol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.bbi.2015.06.001","article-title":"Cumulative meta-analysis of interleukins 6 and 1\u03b2, tumour necrosis factor \u03b1 and C-reactive protein in patients with major depressive disorder","volume":"49","author":"Haapakoski","year":"2015","journal-title":"Brain Behav Immun."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1016\/j.euroneuro.2015.06.007","article-title":"Inflammation and clinical response to treatment in depression: a meta-analysis","volume":"25","author":"Strawbridge","year":"2015","journal-title":"Eur Neuropsychopharmacol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.jad.2019.07.045","article-title":"markers and treatment outcome in treatment resistant depression: a systematic review","volume":"257","author":"Yang","year":"2019","journal-title":"J Affect Disord."},{"key":"B67","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.pnpbp.2013.09.006","article-title":"Efficacy of adjunctive celecoxib treatment for patients with major depressive disorder: a meta-analysis","volume":"48","author":"Na","year":"2014","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry."},{"key":"B68","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1097\/FBP.0000000000000384","article-title":"Tryptophan catabolites along the indoleamine 2,3-dioxygenase pathway as a biological link between depression and cancer","volume":"29","author":"Barreto","year":"2018","journal-title":"Behav Pharmacol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.pnpbp.2017.04.035","article-title":"IDO chronic immune activation and tryptophan metabolic pathway: A potential pathophysiological link between depression and obesity","volume":"80","author":"Chaves-Filho","year":"2018","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"B70","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.euroneuro.2020.11.016","article-title":"European College of Neuropsychopharmacology (ECNP) ImmunoNeuroPsychiatry Thematic Working Group and Marion Leboyer. Brain-immune crosstalk in the treatment of major depressive disorder","volume":"45","author":"Branchi","year":"2021","journal-title":"Eur Neuropsychopharmacol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.phrs.2016.11.013","article-title":"Metabotropic glutamate receptors and neurodegenerative diseases","volume":"115","author":"Ribeiro","year":"2017","journal-title":"Pharmacol Res."},{"key":"B72","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.neubiorev.2015.05.014","article-title":"Inflammation in schizophrenia: a question of balance","volume":"55","author":"Leza","year":"2015","journal-title":"Neurosci Biobehav Rev."},{"key":"B73","doi-asserted-by":"publisher","first-page":"8885","DOI":"10.1007\/s12035-018-1016-x","article-title":"The Compensatory Immune-Regulatory Reflex System (CIRS) in depression and bipolar disorder","volume":"55","author":"Maes","year":"2018","journal-title":"Mol Neurobiol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.euroneuro.2018.12.008","article-title":"Activation of the immune- inflammatory response system and the compensatory immune-regulatory system in antipsychotic naive first episode psychosis","volume":"29","author":"Noto","year":"2019","journal-title":"Eur Neuropsychopharmacol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1007\/s12035-019-01737-z","article-title":"The role of aberrations in the immune-inflammatory response system (IRS) and the compensatory immune-regulatory reflex system (CIRS) in different phenotypes of schizophrenia: the IRS-CIRS theory of schizophrenia","volume":"57","author":"Roomruangwong","year":"2020","journal-title":"Mol Neurobiol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1080\/14737175.2021.1881482","article-title":"Nutrition-based interventions for mood disorders","volume":"21","author":"Martins","year":"2021","journal-title":"Expert Rev Neurother."},{"key":"B77","doi-asserted-by":"publisher","first-page":"2353","DOI":"10.2174\/1381612826666200318152530","article-title":"Diet and neurocognition in mood disorders\u2014an overview of the overlooked","volume":"26","author":"Balanz\u00e1-Mart\u00ednez","year":"2020","journal-title":"Curr Pharm Des."},{"key":"B78","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1007\/s00406-019-01073-2","article-title":"The impact of inflammation on neurocognition and risk for psychosis: a critical review","volume":"270","author":"Kogan","year":"2020","journal-title":"Eur Arch Psychiatry Clin Neurosci."},{"key":"B79","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1159\/000356498","article-title":"Inverse and direct cancer comorbidity in people with central nervous system disorders: a meta-analysis of cancer incidence in 577,013 participants of 50 observational studies","volume":"83","author":"Catal\u00e1-L\u00f3pez","year":"2014","journal-title":"Psychother Psychosom."},{"key":"B80","doi-asserted-by":"publisher","first-page":"31","DOI":"10.4088\/JCP.12r07922","article-title":"Depression as a risk factor for diabetes: a meta-analysis of longitudinal studies","volume":"74","author":"Rotella","year":"2013","journal-title":"J Clin Psychiatry."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/S0033291721001173","article-title":"Misunderstanding precision psychiatry","volume":"28","author":"Vieta","year":"2021","journal-title":"Psychol Med."},{"key":"B82","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.euroneuro.2020.11.001","article-title":"Towards precision medicine what are the stratification hypotheses to identify homogeneous inflammatory subgroups","volume":"45","author":"Ioannou","year":"2021","journal-title":"Eur Neuropsychopharmacol."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2022.883927\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T06:09:40Z","timestamp":1654150180000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2022.883927\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,2]]},"references-count":82,"alternative-id":["10.3389\/fneur.2022.883927"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2022.883927","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,2]]},"article-number":"883927"}}