{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:08:18Z","timestamp":1753891698447,"version":"3.41.2"},"reference-count":59,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010011","name":"Jiangsu Postdoctoral Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Aneurysmal subarachnoid hemorrhage (SAH) is accompanied by cerebral perfusion changes. We aimed to measure the parenchymal blood volume (PBV) maps acquired by C-arm flat-panel detector CT (FDCT) to assess the cerebral blood volume at an early stage in aneurysmal SAH and to explore the correlation with the outcomes at discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data of 66 patients with aneurysmal SAH who underwent FDCT PBV examination were retrospectively analyzed. The PBV of regions of interest, including the cortices of the bilateral frontal lobe, the parietal lobe, the occipital lobe, and the cerebral hemisphere, as well as the basal ganglia, were measured and quantitatively analyzed. The clinical and imaging data of the patients were also collected, and logistic regression analysis was performed to explore the correlation between the perfusion parameters and outcomes at discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The favorable and poor outcomes at discharge were found in 37 (56.06%) and 29 (43.94%) patients, respectively. The whole-brain PBV was significantly correlated with the Hunt-Hess grades (<jats:italic>p<\/jats:italic> &amp;lt; 0.005) and the WFNSS grades (<jats:italic>p<\/jats:italic> &amp;lt; 0.005). The whole-brain PBV of the poor prognosis was significantly higher than that of the favorable prognosis (35.17 \u00b1 7.66 vs. 29.78 \u00b1 5.54, <jats:italic>p<\/jats:italic> &amp;lt; 0.005). The logistic regression analysis showed that the PBV of the parietal lobe at the bleeding side (OR = 1.10, 95%CI: 1.00\u20131.20, <jats:italic>p<\/jats:italic> = 0.04) was an independent risk factor predicting the short-term prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Parenchymal blood volume (PBV) maps could reflect the cerebral blood volume throughout the brain to characterize its perfusion status at an early stage in aneurysmal SAH. It enables a one-stop imaging evaluation and treatment in the same angio-suite and may serve as a reliable technique in clinical assessment of aneurysmal SAH.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2022.888369","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T06:40:14Z","timestamp":1657780814000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Feasibility of FDCT Early Brain Parenchymal Blood Volume Maps in Predicting Short-Term Prognosis in Patients With Aneurysmal Subarachnoid Hemorrhage"],"prefix":"10.3389","volume":"13","author":[{"given":"Lili","family":"Wen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longjiang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoming","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3171\/2016.8.JNS161075","article-title":"Outcome after hunt and hess grade V subarachnoid hemorrhage: a comparison of pre-coiling era (1980\u20131995) vs. post-ISAT era (2005\u20132014)","volume":"75","author":"Konczalla","year":"2017","journal-title":"J Neurosurg"},{"key":"B2","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s12028-016-0347-6","article-title":"What Do We mean by poor-grade aneurysmal subarachnoid hemorrhage and what can we do?","volume":"25","author":"Bosel","year":"2016","journal-title":"Neurocrit Care."},{"key":"B3","doi-asserted-by":"publisher","first-page":"116","DOI":"10.3174\/ajnr.A4061","article-title":"Treatment of poor-grade subarachnoid hemorrhage trial","volume":"36","author":"Mitra","year":"2015","journal-title":"AJNR Am J Neuroradiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.disamonth.2011.08.022","article-title":"Brain aneurysms: epidemiology, treatment options, and milestones of endovascular treatment evolution","volume":"57","author":"Grobelny","year":"2011","journal-title":"Dis Mon."},{"key":"B5","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1007\/s12975-013-0257-2","article-title":"Early brain injury, an evolving frontier in subarachnoid hemorrhage research","volume":"4","author":"Fujii","year":"2013","journal-title":"Transl Stroke Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s40635-014-0030-1","article-title":"Early brain injury linearly correlates with reduction in cerebral perfusion pressure during the hyperacute phase of subarachnoid hemorrhage","volume":"2","author":"Marbacher","year":"2014","journal-title":"Intensive Care Med Exp."},{"first-page":"1","volume-title":"Early Brain Injury or Vasospasm? 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