{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T03:18:13Z","timestamp":1789269493751,"version":"build-2803163510"},"reference-count":7,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>Neuromelioidosis is a rare CNS infection caused by <jats:italic>Burkholderia pseudomallei<\/jats:italic> and is characterized by high morbidity and mortality. Our report presents the diagnostic and therapeutic approach of the first case of neuromelioidosis confirmed in Europe. A 47-year-old man with a medical history of recurrent otitis with otorrhea and fever after tympanoplasty and radical cavity revision operation on the left ear was admitted with headache, decreased level of consciousness, dysarthria, left-sided hemiparesis, and urinary incontinence. After extensive investigations including MRI, microbiological, serological, and CSF analyses, and, ultimately, brain biopsy, a diagnosis of neuromelioidosis was established. Despite antibiotic treatment, the patient showed no clinical improvement and remained in a severely compromised neurological state under mandatory mechanical ventilation. Neuromelioidosis can pose a diagnostic challenge requiring an extensive diagnostic evaluation because of its uncommon clinical and radiological presentations.<\/jats:p>","DOI":"10.3389\/fneur.2022.899396","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T06:13:05Z","timestamp":1659075185000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Case report: First case of neuromelioidosis in Europe: CNS infection caused by Burkholderia pseudomallei"],"prefix":"10.3389","volume":"13","author":[{"given":"Nikolaos G.","family":"Dimitriou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Fl\u00fch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Zange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aykut","family":"Aytulun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Turowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Peter","family":"Hartung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven G.","family":"Meuth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gliem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1016\/S0140-6736(03)13374-0","article-title":"Melioidosis","volume":"361","author":"White","year":"2003","journal-title":"Lancet."},{"key":"B2","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1128\/CMR.4.1.52","article-title":"Melioidosis: the tip of the iceberg?","volume":"4","author":"Dance","year":"1991","journal-title":"Clin Microbiol Rev."},{"key":"B3","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0001-706X(99)00059-5","article-title":"Melioidosis as an emerging global problem","volume":"74","author":"Dance","year":"2000","journal-title":"Acta Trop."},{"key":"B4","doi-asserted-by":"publisher","first-page":"e900","DOI":"10.1371\/journal.pntd.0000900","article-title":"The epidemiology and clinical spectrum of melioidosis: 540 cases from the 20 year Darwin prospective study","volume":"4","author":"Currie","year":"2010","journal-title":"PLoS Negl Trop Dis."},{"key":"B5","doi-asserted-by":"publisher","first-page":"535","DOI":"10.4269\/ajtmh.12-0559","article-title":"Neurologic melioidosis","volume":"89","author":"Deuble","year":"2013","journal-title":"Am J Trop Med Hyg."},{"key":"B6","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1128\/CMR.00006-19","article-title":"Human melioidosis","volume":"33","author":"JGassiep","year":"2020","journal-title":"Clin Microbiol Rev."},{"key":"B7","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1111\/jon.12282","article-title":"Neuromelioidosis: craniospinal MRI findings in burkholderia pseudomallei infection","volume":"26","author":"Hsu","year":"2016","journal-title":"J Neuroimaging."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2022.899396\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T06:13:08Z","timestamp":1659075188000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2022.899396\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,29]]},"references-count":7,"alternative-id":["10.3389\/fneur.2022.899396"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2022.899396","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,29]]},"article-number":"899396"}}