{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T03:48:15Z","timestamp":1773892095994,"version":"3.50.1"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T00:00:00Z","timestamp":1664150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the microstructural changes of the vestibulocochlear nerve in patients with M\u00e9ni\u00e8re's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 26 subjects, 13 patients with MD and 13 healthy controls, underwent diffusion tensor imaging (DTI) on a 3T scanner. The independent sample <jats:italic>t<\/jats:italic>-test was used to compare the differences in fractional anisotropy (FA) and apparent diffusion coefficient (ADC) between the two groups. A Pearson correlation was used between DTI and the dizziness handicap inventory (DHI) scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant decrease in FA and an increase in ADC of the vestibulocochlear nerve in MD patients compared with healthy controls (<jats:italic>P<\/jats:italic> = 0.04, <jats:italic>P<\/jats:italic> = 0.001). FA had negative correlations with the DHI score (<jats:italic>r<\/jats:italic> = \u22120.62, <jats:italic>P<\/jats:italic> = 0.02) and DHI-functional score (<jats:italic>r<\/jats:italic> = \u22120.64, <jats:italic>P<\/jats:italic> = 0.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results are the first evidence of possible changes in the microstructure of the vestibulocochlear nerves in patients with MD. DTI is a potential technique for evaluating the vestibulocochlear nerve in patients with MD.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2022.915826","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T07:18:12Z","timestamp":1664176692000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Microstructural changes of the vestibulocochlear nerve in patients with M\u00e9ni\u00e8re's disease using diffusion tensor imaging"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiaojia","family":"Yuan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaozhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqun","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanfeng","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengguang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"S71","DOI":"10.1007\/s00415-015-7930-1","article-title":"What is Meni\u00e8re's disease? A contemporary re-evaluation of endolymphatic hydrops","volume":"263","author":"G\u00fcrkov","year":"2016","journal-title":"J Neurol."},{"key":"B2","first-page":"1317","article-title":"Observations on the pathology of Meniere's syndrome","volume":"31","author":"Hallpike","year":"1938","journal-title":"Proc R Soc Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1097\/00129492-200111000-00017","article-title":"Diagnosis of endolymphatic hydrops in vivo with magnetic resonance imaging","volume":"22","author":"Niyazov","year":"2001","journal-title":"Otol Neurotol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"73","DOI":"10.2463\/mrms.2013-0080","article-title":"Time course for measuring endolymphatic size in healthy volunteers following intravenous administration of gadoteridol","volume":"13","author":"Naganawa","year":"2014","journal-title":"Magn Reson Med Sci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1177\/0003489415597916","article-title":"Calcium metabolism profile in rat inner ear indicated by MRI after tympanic medial wall administration of manganese chloride","volume":"125","author":"Zou","year":"2016","journal-title":"Ann Otol Rhinol Laryngol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"773","DOI":"10.3174\/ajnr.A2821","article-title":"Comparison of contrast effect on the cochlear perilymph after intratympanic and intravenous gadolinium injection","volume":"33","author":"Yamazaki","year":"2012","journal-title":"AJNR Am J Neuroradiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"E144","DOI":"10.1002\/lary.28576","article-title":"The correlation between endolymphatic hydrops and clinical features of Meniere disease","volume":"131","author":"Zhang","year":"2021","journal-title":"Laryngoscope."},{"key":"B8","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.anl.2012.07.009","article-title":"Visualization of endolymphatic hydrops and correlation with audio-vestibular functional testing in patients with definite Meniere's disease","volume":"40","author":"Seo","year":"2013","journal-title":"Auris Nasus Larynx."},{"key":"B9","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1002\/lary.25576","article-title":"The correlation between symptoms of definite Meniere's disease and endolymphatic hydrops visualized by magnetic resonance imaging","volume":"126","author":"Wu","year":"2016","journal-title":"Laryngoscope."},{"key":"B10","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.anl.2016.01.006","article-title":"The change of hippocampal volume and its relevance with inner ear function in Meniere's disease patients","volume":"43","author":"Seo","year":"2016","journal-title":"Auris Nasus Larynx."},{"key":"B11","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0006-3495(94)80775-1","article-title":"MR diffusion tensor spectroscopy and imaging","volume":"66","author":"Basser","year":"1994","journal-title":"Biophys J."},{"key":"B12","doi-asserted-by":"crossref","DOI":"10.1063\/1.1695690","article-title":"Spin diffusion measurements: spin echoes in the presence of a time-dependent field gradient","author":"Stejskal","year":"1965","journal-title":"J Chem Phys."},{"key":"B13","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1148\/radiology.176.2.2367658","article-title":"Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system","volume":"176","author":"Moseley","year":"1990","journal-title":"Radiology."},{"key":"B14","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1002\/nbm.782","article-title":"The basis of anisotropic water diffusion in the nervous system: a technical review","volume":"15","author":"Beaulieu","year":"2002","journal-title":"NMR Biomed."},{"key":"B15","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/nbm.1940080707","article-title":"Inferring microstructural features and the physiological state of tissues from diffusion-weighted images","volume":"8","author":"Basser","year":"1995","journal-title":"NMR Biomed."},{"key":"B16","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1148\/radiology.201.3.8939209","article-title":"Diffusion tensor MR imaging of the human brain","volume":"201","author":"Pierpaoli","year":"1996","journal-title":"Radiology."},{"key":"B17","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s00234-017-1816-0","article-title":"Diffusion tensor imaging as a prognostic biomarker for motor recovery and rehabilitation after stroke","volume":"59","author":"Puig","year":"2017","journal-title":"Neuroradiology."},{"key":"B18","doi-asserted-by":"publisher","first-page":"e943","DOI":"10.1212\/WNL.0000000000010235","article-title":"A prospective harmonized multicenter DTI study of cerebral white matter degeneration in ALS","volume":"95","author":"Kalra","year":"2020","journal-title":"Neurology."},{"key":"B19","doi-asserted-by":"publisher","first-page":"68S","DOI":"10.1177\/1051228405283363","article-title":"Diffusion tensor magnetic resonance imaging in multiple sclerosis","volume":"15","author":"Goldberg-Zimring","year":"2005","journal-title":"J Neuroimag."},{"key":"B20","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1111\/j.1528-1167.2012.03426.x","article-title":"meta-analysis of white matter changes in temporal lobe epilepsy as studied with diffusion tensor imaging","volume":"53","author":"Otte","year":"2012","journal-title":"Epilepsia."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.heares.2015.01.010","article-title":"Diffusion tensor imaging of the vestibulocochlear nerve in patients with long-term single-sided deafness","volume":"323","author":"Vos","year":"2015","journal-title":"Hear Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"697","DOI":"10.3171\/2011.12.JNS111404","article-title":"Preoperative identification of the facial nerve in patients with large cerebellopontine angle tumors using high-density diffusion tensor imaging","volume":"116","author":"Roundy","year":"2012","journal-title":"J Neurosurg."},{"key":"B23","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s00062-018-0733-x","article-title":"Diffusion-tensor tractography of the auditory neural pathway: clinical usefulness in patients with unilateral sensorineural hearing loss","volume":"30","author":"Kim","year":"2020","journal-title":"Clin Neuroradiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1161\/STROKEAHA.112.680223","article-title":"Changes in normal-appearing white matter precede development of white matter lesions","volume":"44","author":"De Groot","year":"2013","journal-title":"Stroke."},{"key":"B25","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1097\/RLI.0000000000000394","article-title":"Diffusion tensor imaging in chronic inflammatory demyelinating polyneuropathy: diagnostic accuracy and correlation with electrophysiology","volume":"52","author":"Kronlage","year":"2017","journal-title":"Invest Radiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.pmr.2012.08.011","article-title":"Electrodiagnosis of lumbar radiculopathy","volume":"24","author":"Barr","year":"2013","journal-title":"Phys Med Rehabil Clin N Am."},{"key":"B27","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1001\/archotol.1990.01870040046011","article-title":"The development of the dizziness handicap inventory","volume":"116","author":"Jacobson","year":"1990","journal-title":"Arch Otolaryngol Head Neck Surg."},{"key":"B28","doi-asserted-by":"publisher","first-page":"e0130833","DOI":"10.1371\/journal.pone.0130833","article-title":"Peripheral nerve diffusion tensor imaging: assessment of axon and myelin sheath integrity","volume":"10","author":"Heckel","year":"2015","journal-title":"PLoS ONE."},{"key":"B29","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1002\/jmri.22442","article-title":"In vivo assessment of peripheral nerve regeneration by diffusion tensor imaging","volume":"33","author":"Morisaki","year":"2011","journal-title":"J Magn Reson Imag."},{"key":"B30","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1212\/WNL.52.8.1626","article-title":"Diffusion tensor imaging of lesions and normal-appearing white matter in multiple sclerosis","volume":"52","author":"Werring","year":"1999","journal-title":"Neurology."},{"key":"B31","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1097\/00002142-200410000-00004","article-title":"Diffusion tensor imaging in cerebral tumor diagnosis and therapy","volume":"15","author":"Field","year":"2004","journal-title":"Top Magn Reson Imag."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nbd.2014.02.007","article-title":"Diffusion fMRI detects white-matter dysfunction in mice with acute optic neuritis","volume":"67","author":"Lin","year":"2014","journal-title":"Neurobiol Dis."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1097\/MAO.0000000000002365","article-title":"The component structure of the dizziness handicap inventory (DHI): a reappraisal","volume":"40","author":"Van De Wyngaerde","year":"2019","journal-title":"Otol Neurotol."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2022.915826\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T07:18:23Z","timestamp":1664176703000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2022.915826\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,26]]},"references-count":33,"alternative-id":["10.3389\/fneur.2022.915826"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2022.915826","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,26]]},"article-number":"915826"}}