{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T21:12:06Z","timestamp":1779138726898,"version":"3.51.4"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>The cause of idiopathic normal pressure hydrocephalus's (iNPH) clinical symptoms remains unclear. The cerebral cortex is the center of the brain and provides a structural basis for complex perception and motor function. This study aimed to explore the relationship between changes in cerebral cortex volume and clinical symptoms in patients with iNPH. This study included 21 iNPH patients and 20 normal aging (NA) controls. Voxel-based morphometry statistical results showed that, compared with NA, the gray matter volumes of patients with iNPH in the bilateral temporal lobe, bilateral hippocampus, bilateral thalamus, bilateral insula, left amygdala, right lenticular nucleus, right putamen, and cerebellum decreased, while the volumes of gray matter in the bilateral paracentral lobules, precuneus, bilateral supplementary motor area, medial side of the left cerebral hemisphere, and median cingulate and paracingulate gyri increased. Correlation analysis among the volumes of white matter and gray matter in the cerebrum and cerebellum and the iNPH grading scale (iNPHGS) revealed that the volume of white matter was negatively correlated with the iNPHGS (<jats:italic>P<\/jats:italic> &amp;lt; 0.05), while the gray matter volumes of cerebellar area 6 and area 8 were negatively correlated with the clinical symptoms of iNPH (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). The volume of gray matter in the cerebellar vermis was negatively correlated with gait, and the gray matter volume of cerebellar area 6 was negatively correlated with cognition. Our findings suggest that the cerebellum also plays an important role in the pathogenesis of iNPH, potentially highlighting new research avenues for iNPH.<\/jats:p>","DOI":"10.3389\/fneur.2022.922199","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T04:50:46Z","timestamp":1662526246000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Gray matter volume of cerebellum associated with idiopathic normal pressure hydrocephalus: A cross-sectional analysis"],"prefix":"10.3389","volume":"13","author":[{"given":"Minrui","family":"Lv","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiakuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haihua","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duanming","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1111\/cns.13526","article-title":"Pathogenesis and pathophysiology of idiopathic normal pressure hydrocephalus","volume":"26","author":"Wang","year":"2020","journal-title":"CNS Neurosci Ther."},{"key":"B2","doi-asserted-by":"publisher","first-page":"63","DOI":"10.2176\/nmc.st.2020-0292","article-title":"Guidelines for management of idiopathic normal pressure hydrocephalus (third edition): endorsed by the japanese society of normal pressure hydrocephalus","volume":"61","author":"Nakajima","year":"2021","journal-title":"Neurol Med Chir."},{"key":"B3","doi-asserted-by":"publisher","first-page":"775","DOI":"10.2176\/nmc.52.775","article-title":"Guidelines for management of idiopathic normal pressure hydrocephalus: second edition","volume":"52","author":"Mori","year":"2012","journal-title":"Neurol Med Chir"},{"key":"B4","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1007\/s00234-020-02361-8","article-title":"A new index for assessing cerebral ventricular volume in idiopathic normal-pressure hydrocephalus: a comparison with Evans' index","volume":"62","author":"He","year":"2020","journal-title":"Neuroradiology"},{"key":"B5","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.jocn.2020.11.020","article-title":"Role of DESH, callosal angle and cingulate sulcus sign in prediction of gait responsiveness after shunting in iNPH patients","volume":"83","author":"Skalick\u00fd","year":"2021","journal-title":"J Clin Neurosci"},{"key":"B6","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/psyg.12001","article-title":"Reversibility of brain morphology after shunt operations and preoperative clinical symptoms in patients with idiopathic normal pressure hydrocephalus","volume":"13","author":"Wada","year":"2013","journal-title":"Psychogeriatrics"},{"key":"B7","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1111\/jon.12521","article-title":"Cortical thickness estimations of FreeSurfer and the CAT12 toolbox in patients with Alzheimer's disease and healthy controls","volume":"28","author":"Seiger","year":"2018","journal-title":"J Neuroimaging."},{"key":"B8","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1159\/000119521","article-title":"Voxel-based analysis of gray matter and CSF space in idiopathic normal pressure hydrocephalus","volume":"25","author":"Ishii","year":"2008","journal-title":"Dement Geriatr Cogn Disord"},{"key":"B9","doi-asserted-by":"publisher","first-page":"21213","DOI":"10.1038\/s41598-020-78067-x","article-title":"Abnormal cortical thickening and thinning in idiopathic normal-pressure hydrocephalus","volume":"10","author":"Kang","year":"2020","journal-title":"Sci Rep."},{"key":"B10","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s40673-020-00119-9","article-title":"Cerebellum and micturition: what do we know? 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