{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:53:45Z","timestamp":1790207625787,"version":"4.1.0"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005881","name":"Emberi Eroforr\u00e1sok Miniszt\u00e9riuma","doi-asserted-by":"publisher","award":["FK135870"],"award-info":[{"award-number":["FK135870"]}],"id":[{"id":"10.13039\/501100005881","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005881","name":"Emberi Eroforr\u00e1sok Miniszt\u00e9riuma","doi-asserted-by":"publisher","award":["K139415"],"award-info":[{"award-number":["K139415"]}],"id":[{"id":"10.13039\/501100005881","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["H2020-MSCA-RISE-2016 734718"],"award-info":[{"award-number":["H2020-MSCA-RISE-2016 734718"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>Visual dysfunction is a recognized early symptom of Parkinson's disease (PD) that partly scales motor symptoms, yet its background is heterogeneous. With additional deficits in visuospatial attention, the two systems are hard to disentangle and it is not known whether impaired functional connectivity in the visual cortex is translative in nature or disrupted attentional modulation also contributes. In this study, we investigate functional connectivity modulation during a visuospatial attention task in patients with PD. In total, 15 PD and 16 age-matched healthy controls performed a visuospatial attention task while undergoing fMRI, in addition to a resting-state fMRI scan. Tensorial independent component analysis was used to investigate task-related network activity patterns. Independently, an atlas-based connectivity modulation analysis was performed using the task potency method. Spearman's rank correlation was calculated between task-related network expression, connectivity modulation, and clinical characteristics. Task-related networks including mostly visual, parietal, and prefrontal cortices were expressed to a significantly lesser degree in patients with PD (<jats:italic>p<\/jats:italic> &amp;lt; 0.027). Resting-state functional connectivity did not differ between the healthy and diseased cohorts. Connectivity between the precuneus and ventromedial prefrontal cortex was modulated to a higher degree in patients with PD (<jats:italic>p<\/jats:italic> &amp;lt; 0.004), while connections between the posterior parietal cortex and primary visual cortex, and also the superior frontal gyrus and opercular cortex were modulated to a lesser degree (<jats:italic>p<\/jats:italic> &amp;lt; 0.001 and <jats:italic>p<\/jats:italic> &amp;lt; 0.011). Task-related network expression and superior frontal gyrus\u2013opercular cortex connectivity modulation were significantly associated with UPDRSIII motor scores and the Hoehn\u2013Yahr stages (<jats:italic>R<\/jats:italic> = \u22120.72, <jats:italic>p<\/jats:italic> &amp;lt; 0.006 and <jats:italic>R<\/jats:italic> = \u22120.90, <jats:italic>p<\/jats:italic> &amp;lt; 0.001; <jats:italic>R<\/jats:italic> = \u22120.68, <jats:italic>p<\/jats:italic> &amp;lt; 0.01 and <jats:italic>R<\/jats:italic> = \u22120.71, <jats:italic>p<\/jats:italic> &amp;lt; 0.007). Task-related networks function differently in patients with PD in association with motor symptoms, whereas impaired modulation of visual and default-mode network connectivity was not correlated with motor function.<\/jats:p>","DOI":"10.3389\/fneur.2022.927481","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T07:51:39Z","timestamp":1660031499000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Modulation of cortical resting state functional connectivity during a visuospatial attention task in Parkinson's disease"],"prefix":"10.3389","volume":"13","author":[{"given":"D\u00e1niel","family":"Ver\u00e9b","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rton Attila","family":"Kov\u00e1cs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szabolcs","family":"Antal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kriszti\u00e1n","family":"Kocsis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikoletta","family":"Szab\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1lint","family":"Kincses","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bence","family":"Bozsik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Farag\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eszter","family":"T\u00f3th","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e1s","family":"Kir\u00e1ly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Kliv\u00e9nyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9nes","family":"Z\u00e1dori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsigmond Tam\u00e1s","family":"Kincses","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","article-title":"Parkinson's disease","volume":"397","author":"Bloem","year":"2021","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1212\/01.wnl.0000191565.11065.11","article-title":"Visual dysfunction in Parkinson disease without dementia","volume":"65","author":"Uc","year":"2005","journal-title":"Neurology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1177\/0891988705284739","article-title":"Impaired visual acuity as a risk factor for visual hallucinations in Parkinson's disease","volume":"19","author":"Matsui","year":"2006","journal-title":"J Geriatr Psychiatry Neurol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"140372","DOI":"10.3233\/JPD-140372","article-title":"Non-motor symptoms profile and burden in drug na\u00efve versus long-term Parkinson's disease patients","volume":"4","author":"Zis","year":"2014","journal-title":"J Parkinsons Dis"},{"key":"B5","doi-asserted-by":"publisher","first-page":"aww175","DOI":"10.1093\/brain\/aww175","article-title":"Visual dysfunction in Parkinson's disease","volume":"139","author":"Weil","year":"2016","journal-title":"Brain"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3171\/2021.3.jns204329","article-title":"Correlation of visual area with tremor improvement after MRgFUS thalamotomy in Parkinson's disease","volume":"2021","author":"Xiong","year":"2021","journal-title":"J Neurosurg"},{"key":"B7","doi-asserted-by":"publisher","first-page":"2980","DOI":"10.1093\/brain\/awp223","article-title":"Impaired visual processing preceding image recognition in Parkinson's disease patients with visual hallucinations","volume":"132","author":"Meppelink","year":"2009","journal-title":"Brain."},{"key":"B8","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1093\/brain\/awt360","article-title":"Visuoperceptive region atrophy independent of cognitive status in patients with Parkinson's disease with hallucinations","volume":"137","author":"Goldman","year":"2014","journal-title":"Brain."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150013","article-title":"Visuospatial attention to single and multiple objects is independently impaired in Parkinson's disease","author":"Norton","year":"","journal-title":"PLoS ONE"},{"key":"B10","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1037\/0894-4105.11.1.44","article-title":"Visuospatial dysfunction and problem solving in Parkinson's disease","volume":"11","author":"Cronin-Golomb","year":"1997","journal-title":"Neuropsychology."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1002\/mds.22560","article-title":"Neuroanatomical substrate of visuospatial and visuoperceptual impairment in Parkinson's disease","volume":"24","author":"Pereira","year":"2009","journal-title":"Mov Disord."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nicl.2016.11.004","article-title":"Executive attention networks show altered relationship with default mode network in PD","volume":"13","author":"Boord","year":"2017","journal-title":"NeuroImage Clin."},{"key":"B13","doi-asserted-by":"publisher","first-page":"61042","DOI":"10.3390\/diagnostics11061042","article-title":"The cerebellum is a common key for visuospatial execution and attention in Parkinson's disease","volume":"11","author":"Sako","year":"2021","journal-title":"Diagnostics"},{"key":"B14","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.parkreldis.2014.10.017","article-title":"Akinetic-rigid and tremor-dominant Parkinson's disease patients show different patterns of intrinsic brain activity","volume":"21","author":"Zhang","year":"2015","journal-title":"Parkinsonism Relat Disord."},{"key":"B15","doi-asserted-by":"publisher","first-page":"5429","DOI":"10.1038\/s41380-020-0770-0","article-title":"Longitudinal brain connectivity changes and clinical evolution in Parkinson's disease","volume":"26","author":"Filippi","year":"2021","journal-title":"Mol Psychiatry."},{"key":"B16","doi-asserted-by":"publisher","first-page":"S52","DOI":"10.1016\/j.parkreldis.2015.09.006","article-title":"Impact of Parkinson's disease and levodopa on resting state functional connectivity related to speech prosody control","volume":"22","author":"Elfmarkov\u00e1","year":"2016","journal-title":"Parkinsonism Relat Disord."},{"key":"B17","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.neuroimage.2018.09.059","article-title":"Disentangling common from specific processing across tasks using task potency","volume":"184","author":"Chauvin","year":"2019","journal-title":"Neuroimage."},{"key":"B18","doi-asserted-by":"publisher","first-page":"3059","DOI":"10.1523\/JNEUROSCI.4621-08.2009","article-title":"Neural suppression of irrelevant information underlies optimal working memory performance","volume":"29","author":"Zanto","year":"2009","journal-title":"J Neurosci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.neuroimage.2004.07.051","article-title":"Advances in functional and structural MR image analysis and implementation as FSL","volume":"7","author":"Smith","year":"2004","journal-title":"In: NeuroImage."},{"key":"B20","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1002\/hbm.10062","article-title":"Fast robust automated brain extraction","volume":"17","author":"Smith","year":"2002","journal-title":"Hum Brain Mapp."},{"key":"B21","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.neuroimage.2015.02.064","article-title":"A robust ICA-based strategy for removing motion artifacts from fMRI data","volume":"112","author":"Pruim","year":"2015","journal-title":"Neuroimage."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1016\/j.neuroimage.2007.09.070","article-title":"Model-free characterization of brain functional networks for motor sequence learning using fMRI","volume":"39","author":"Kincses","year":"2008","journal-title":"Neuroimage."},{"key":"B23","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.neuroimage.2004.10.043","article-title":"Tensorial extensions of independent component analysis for multisubject FMRI analysis","volume":"25","author":"Beckmann","year":"2005","journal-title":"Neuroimage."},{"key":"B24","doi-asserted-by":"publisher","first-page":"3095","DOI":"10.1093\/cercor\/bhx179","article-title":"Local-global parcellation of the human cerebral cortex from intrinsic functional connectivity MRI","volume":"28","author":"Schaefer","year":"2018","journal-title":"Cereb Cortex."},{"key":"B25","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.neuroimage.2018.01.003","article-title":"Thresholding functional connectomes by means of mixture modeling","volume":"171","author":"Bielczyk","year":"2018","journal-title":"Neuroimage."},{"key":"B26","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.neuroimage.2014.01.060","article-title":"Permutation inference for the general linear model","volume":"92","author":"Winkler","year":"2014","journal-title":"Neuroimage."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1152\/jn.00338.2011","article-title":"The organization of the human cerebral cortex estimated by intrinsic functional connectivity","volume":"106","author":"Yeo","year":"2011","journal-title":"J Neurophysiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1186\/s12883-021-02366-7","article-title":"Impairment of the visuospatial working memory in the patients with Parkinson's Disease: an fMRI study","volume":"21","author":"Kawashima","year":"2021","journal-title":"BMC Neurol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"562","DOI":"10.3389\/fneur.2020.00562","article-title":"Parietal perfusion alterations in Parkinson's disease patients without dementia","volume":"11","author":"Pelizzari","year":"2020","journal-title":"Front Neurol"},{"key":"B30","volume-title":"Statistical Parametric Mapping: The Analysis of Functional Brain Images","author":"Penny","year":"2011"},{"key":"B31","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s12868-016-0254-y","article-title":"Reduced task-related functional connectivity during a set-shifting task in unmedicated early-stage Parkinson's disease patients","volume":"17","author":"de Bondt","year":"2016","journal-title":"BMC Neurosci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"637","DOI":"10.3233\/JPD-191592","article-title":"Functional connectivity signatures of Parkinson's disease","volume":"9","author":"Tessitore","year":"2019","journal-title":"J Parkinsons Dis."},{"key":"B33","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/j.nicl.2018.03.013","article-title":"Resting-state connectivity in neurodegenerative disorders: Is there potential for an imaging biomarker?","volume":"18","author":"Hohenfeld","year":"2018","journal-title":"NeuroImage Clin."},{"key":"B34","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.neuron.2014.05.014","article-title":"Intrinsic and task-evoked network architectures of the human brain","volume":"83","author":"Cole","year":"2014","journal-title":"Neuron."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1016\/j.neuroimage.2012.03.068","article-title":"A generalized form of context-dependent psychophysiological interactions (gPPI): a comparison to standard approaches","volume":"61","author":"McLaren","year":"2012","journal-title":"Neuroimage."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1016\/S1053-8119(03)00202-7","article-title":"Dynamic causal modelling","volume":"19","author":"Friston","year":"2003","journal-title":"Neuroimage."},{"key":"B37","doi-asserted-by":"publisher","first-page":"66","DOI":"10.3389\/fnint.2014.00066","article-title":"Frontal eye field, where art thou? Anatomy, function, and non-invasive manipulation of frontal regions involved in eye movements and associated cognitive operations","volume":"8","author":"Vernet","year":"2014","journal-title":"Front Integr Neurosci"},{"key":"B38","doi-asserted-by":"publisher","first-page":"3315","DOI":"10.1093\/brain\/awl244","article-title":"Functions of the left superior frontal gyrus in humans: a lesion study","volume":"129","author":"du Boisgueheneuc","year":"2006","journal-title":"Brain."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2530","DOI":"10.1002\/hbm.20688","article-title":"At the heart of the ventral attention system: the right anterior insula","volume":"30","author":"Eckert","year":"2009","journal-title":"Hum Brain Mapp."},{"key":"B40","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/S0165-0173(99)00040-5","article-title":"Basal ganglia and cerebellar loops: motor and cognitive circuits","volume":"31","author":"Middleton","year":"2000","journal-title":"Brain Res Brain Res Rev."},{"key":"B41","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.cub.2006.11.063","article-title":"Spatial attention changes excitability of human visual cortex to direct stimulation","volume":"17","author":"Bestmann","year":"2007","journal-title":"Curr Biol."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2022.927481\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T07:51:42Z","timestamp":1660031502000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2022.927481\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,9]]},"references-count":41,"alternative-id":["10.3389\/fneur.2022.927481"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2022.927481","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,9]]},"article-number":"927481"}}