{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:09:42Z","timestamp":1753891782887,"version":"3.41.2"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008474","name":"New Jersey Commission on Brain Injury Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008474","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Post-traumatic headache (PTH) is commonly reported after concussion. Calcitonin gene-related peptide (CGRP) is implicated in the pathogenesis of migraine. We explored how single nucleotide polymorphisms (SNPs) from CGRP-alpha (CALCA) and the receptor activity modifying protein-1 (RAMP1) related to headache burden during the first week after concussion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective study was performed in 34 collegiate athletes who sustained a concussion. Participants completed the symptom evaluation checklist from the SCAT3 within 48 h of injury (V1), and again 4 (V2) and 7 (V3) days after injury. For each visit, the self-reported score (0\u20136) for headache, pressure in head, blurred vision, and sensitivity to light\/noise were reported and summed to calculate the headache burden. A saliva sample was obtained and genotyped for CALCA (rs3781719) and RAMP1 (rs10185142). RAMP1 (TT, TC, CC) and CALCA (AA, AG, GG) were dichotomized (A+, A- and T+, T-, respectively), and concatenated (T+A+, T+A-, T-A+, T-A-) for analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Headache Burden at Visit 1 was greatest in T+A+ compared to T-A+, and trended toward a significant difference with T+A-. Repeated-measures ANOVA revealed the presence of significant visit main effects (<jats:italic>p<\/jats:italic>&amp;lt; 0.001, \u03b7<jats:sup>2<\/jats:sup>= 0.404), but the group (<jats:italic>p<\/jats:italic>= 0.055) and interaction effects only trended (<jats:italic>p<\/jats:italic>= 0.094). Pearson's \u03c7<jats:sup>2<\/jats:sup>-tests revealed that 88% of those with return-to play (RTP) exclusions \u226515 days had PTH with multi-sensory symptoms (PTH+SENS) as compared to 35% in those with RTP &amp;lt; 14 day.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Knowledge of RAMP1 and CALCA genotypes appear to improve an understanding the presenting features and magnitude of headache burden after concussion injury.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2022.947524","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T08:51:50Z","timestamp":1659689510000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Observations from a prospective small cohort study suggest that CGRP genes contribute to acute posttraumatic headache burden after concussion"],"prefix":"10.3389","volume":"13","author":[{"given":"Michael F.","family":"La 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