{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T02:02:39Z","timestamp":1771639359030,"version":"3.50.1"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>While monocyte to high-density lipoprotein cholesterol ratio (MHR) has been reported to be associated with nervous system lesions, the role of MHR has not been determined in patients with Guillain-Barr\u00e9 Syndrome (GBS). The purpose of our study was to explore the role of MHR in patients with GBS. A total of 52 GBS patients were involved in the study retrospectively, including patients with acute inflammatory demyelinating polyradiculoneuropathy (AIDP), acute motor axonal neuropathy (AMAN), and acute motor sensory axonal neuropathy (AMSAN). We used Hughes Functional Grading Scale (HFGS) score to evaluate functional status in GBS patients. Among patients with different subtypes of GBS, MHR was significantly elevated in those with demyelination compared to patients without demyelination (<jats:italic>p<\/jats:italic> &amp;lt; 0.001); AIDP patients had an increased MHR compared with AMAN or AMSAN patients (<jats:italic>p<\/jats:italic> = 0.001; <jats:italic>p<\/jats:italic> = 0.013). There was a positive correlation between MHR and HFGS score (r = 0.463, <jats:italic>p<\/jats:italic> = 0.006) in AIDP patients, but not in AMAN or AMSAN. Multiple linear regression analysis revealed that MHR was independently associated with HFGS score (beta = 0.405, <jats:italic>p<\/jats:italic> = 0.013) in AIDP patients. Our study suggests that MHR as an inflammatory marker is elevated in patients with AIDP compared to AMAN or AMSAN patients, while MHR has a positive correlation with clinical severity in AIDP patients, suggesting that MHR may provide an additional information to reflect the pathophysiology of AIDP.<\/jats:p>","DOI":"10.3389\/fneur.2022.955933","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T06:13:15Z","timestamp":1664259195000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Elevated monocyte to high-density lipoprotein cholesterol ratio correlates with clinical severity in acute inflammatory demyelinating polyradiculoneuropathy patients"],"prefix":"10.3389","volume":"13","author":[{"given":"You-Fan","family":"Peng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing-Song","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/S1474-4422(08)70215-1","article-title":"Clinical features, pathogenesis, and treatment of Guillain\u2013Barre syndrome","volume":"7","author":"van Doorn","year":"2008","journal-title":"Lancet Neurol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"564098","DOI":"10.1155\/2015\/564098","article-title":"Biomarkers of Guillain-Barr\u00e9 syndrome: some recent progress, more still to be explored","volume":"2015","author":"Wang","year":"2015","journal-title":"Mediators Inflamm."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.3389\/fimmu.2019.02035","article-title":"Human monocyte subsets and phenotypes in major chronic inflammatory diseases","volume":"10","author":"Kapellos","year":"2019","journal-title":"Front Immunol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"575","DOI":"10.2459\/JCM.0b013e32834bb3c8","article-title":"High-density lipoprotein levels and risk of cardiovascular events: a review","volume":"13","author":"Mureddu","year":"2012","journal-title":"J Cardiovasc Med (Hagerstown)."},{"key":"B5","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.tcm.2005.05.008","article-title":"The role of high-density lipoprotein in inflammation","volume":"15","author":"Navab","year":"2005","journal-title":"Trends Cardiovasc Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"275","DOI":"10.4103\/aian.AIAN_249_19","article-title":"Relation between the novel marker monocyte to high-density lipoprotein cholesterol ratio and severity in multiple sclerosis","volume":"23","author":"Ulusoy","year":"2020","journal-title":"Ann Indian Acad Neurol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1080\/01616412.2019.1710406","article-title":"Correlations between the monocyte to high-density lipoprotein cholesterol ratio and white matter hyperintensities in migraine","volume":"42","author":"Ulusoy","year":"2020","journal-title":"Neurol Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e12857","DOI":"10.1097\/MD.0000000000012857","article-title":"Monocyte-to-high density lipoprotein ratio is associated with a decreased compound muscle action potential amplitude in patients with diabetic axonal polyneuropathy","volume":"97","author":"Vural","year":"2018","journal-title":"Medicine (Baltimore)."},{"key":"B9","doi-asserted-by":"publisher","first-page":"S21","DOI":"10.1002\/ana.410270707","article-title":"Assessment of current diagnostic criteria for Guillain-Barre' syndrome","volume":"27","author":"Asbury","year":"1990","journal-title":"Ann Neurol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1093\/brain\/118.3.597","article-title":"Guillain-Barr\u00e9 syndrome in northern China. 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