{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:13:19Z","timestamp":1793502799778,"version":"4.5.0"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T00:00:00Z","timestamp":1661385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016080","name":"Hui Hoy and Chow Sin Lan Charity Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016080","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Obstructive sleep apnea (OSA) is associated with cerebral small vessel disease (CSVD). Nonetheless, whether OSA-risk determined by a simple screening questionnaire or indices quantifying nocturnal hypoxemia other than the conventional apnea\u2013hypopnea index (AHI) by the home sleep apnea test (HSAT) associated with CSVD burden remains uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From 2018 to 2021, we recruited patients with transient ischemic attack (TIA)\/minor stroke from the Queen Mary Hospital Acute Stroke Unit and TIA\/Stroke Outpatient Clinics. Logistic regression models were applied to determine the association of baseline OSA-risk (on STOP-BANG questionnaire) or HSAT-derived indices quantifying nocturnal hypoxemia with global burden\/individual markers of CSVD on MRI. Indices included oxygen desaturation (\u22653%) index (ODI), minimum oxygen saturation (SpO<jats:sub>2<\/jats:sub>), percentage of total sleep time with an oxygen saturation &amp;lt;90% (CT90%), and desaturation duration (\u22653%, DesDur).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 283 patients with TIA\/minor stroke (mean age 65 years, 64% men), OSA-risk was significantly associated with total CSVD score (multivariate-adjusted odds ratio: 1.23, 95% confidence interval 1.01\u20131.51), presence of lacunes [1.39 (1.09\u20131.79)] and burden of basal ganglia PVSs [1.32 (1.06\u20131.67)]. In 85\/283 patients who completed HSAT, neither AHI, minimum SpO<jats:sub>2<\/jats:sub> nor CT90% was associated with CSVD burden. Nonetheless, ODI and DesDur remained significantly associated with total CSVD score after covariate adjustment: ODI [1.04 (1.01\u20131.07)] and DesDur [1.04 (1.01\u20131.08)].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with TIA\/minor stroke, high OSA-risk was associated with a greater CSVD burden. Oxygen desaturation indices (ODI and DesDur) rather than AHI were independently associated with global CSVD burden, indicating that longer and more severe desaturations may contribute to the pathogenesis of CSVD.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2022.956208","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T06:17:35Z","timestamp":1661408255000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Associations of sleep apnea risk and oxygen desaturation indices with cerebral small vessel disease burden in patients with stroke"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiaodi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Chi-Leung","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry 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