{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:08:46Z","timestamp":1793210926412,"version":"4.5.0"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["Z161100000516165"],"award-info":[{"award-number":["Z161100000516165"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>Disorders of consciousness (DOC) are one of the most frequent complications in patients after severe brain injury, mainly caused by trauma, stroke, and anoxia. With the development of neuromodulation techniques, novel therapies including deep brain stimulation (DBS) and spinal cord stimulation (SCS) have been employed to treat DOC. Here, we report the case of a DOC patient receiving short-term SCS (st-SCS) treatment and showing improvement monitored by resting-state fMRI (rs-fMRI) and quantitative EEG (qEEG). A 35-year-old male with severe traumatic brain injury remained comatose for 3 months. The patient was evaluated using JFK coma recovery scale\u2014revised (CRS-R) and showed no improvement within 1 month. He received st-SCS surgery 93 days after the injury and the stimulation was applied the day after surgery. He regained communication according to instructions on day 21 after surgery and improved from a vegetative state\/unwakefulness syndrome to an emergence from a minimally conscious state. To our knowledge, this report is the first published case of st-SCS in a patient with DOC. These results shed light that st-SCS may be effective in treating certain patients with DOC, which may reduce patients' suffering during treatment and lessen financial burden.<\/jats:p>","DOI":"10.3389\/fneur.2022.968932","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T04:40:22Z","timestamp":1666672822000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Short-term spinal cord stimulation in treating disorders of consciousness monitored by resting-state fMRI and qEEG: The first case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Yi","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiheng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/S1474-4422(19)30031-6","article-title":"therapeutic interventions in patients with prolonged disorders of consciousness","volume":"18","author":"Thibaut","year":"2019","journal-title":"Lancet Neurol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1056\/NEJMoa1102609","article-title":"Placebo-controlled trial of amantadine for severe traumatic brain injury","volume":"366","author":"Giacino","year":"2012","journal-title":"N Engl J Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"4167","DOI":"10.2174\/13816128113196660654","article-title":"Amantadine, apomorphine and zolpidem in the treatment of disorders of consciousness","volume":"20","author":"Gosseries","year":"2013","journal-title":"Curr Pharm Des"},{"key":"B4","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1007\/s12264-018-0244-4","article-title":"Current status of neuromodulatory therapies for disorders of consciousness","volume":"34","author":"Xia","year":"2018","journal-title":"Neurosci Bull."},{"key":"B5","first-page":"157","volume":"16","author":"Kanno","year":"1988","journal-title":"No Shinkei Geka."},{"key":"B6","doi-asserted-by":"publisher","first-page":"13870","DOI":"10.1111\/cns.13870","article-title":"Long-term functional prognosis and related factors of spinal cord stimulation in patients with disorders of consciousness","volume":"28","author":"Yang","year":"2022","journal-title":"CNS Neurosci Ther."},{"key":"B7","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.neuroscience.2017.01.036","article-title":"et al. Spinal cord stimulation modulates frontal delta and gamma in patients of minimally consciousness state","volume":"346","author":"Bai","year":"2017","journal-title":"Neuroscience"},{"key":"B8","doi-asserted-by":"publisher","first-page":"36173","DOI":"10.7554\/eLife.36173","article-title":"Prognostication of chronic disorders of consciousness using brain functional networks and clinical characteristics","volume":"7","author":"Song","year":"2018","journal-title":"Elife."},{"key":"B9","doi-asserted-by":"publisher","first-page":"3945","DOI":"10.1007\/s00018-020-03512-z","article-title":"Prognostic models for prolonged disorders of consciousness: an integrative review","volume":"77","author":"Song","year":"2020","journal-title":"Cell Mol Life Sci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1111\/j.1525-1403.2012.00458.x","article-title":"Central thalamic deep brain stimulation to promote recovery from chronic posttraumatic minimally conscious state: challenges and opportunities","volume":"15","author":"Giacino","year":"2012","journal-title":"Neuromodulation."},{"key":"B11","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1159\/000348271","article-title":"Neuromodulation of vegetative state through spinal cord stimulation: where are we now and where are we going?","volume":"91","author":"Della Pepa","year":"2013","journal-title":"Stereotact Funct Neurosurg"},{"key":"B12","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1159\/000329357","article-title":"et al. Spinal cord stimulation and cerebral hemodynamics: updated mechanism and therapeutic implications","volume":"89","author":"Visocchi","year":"2011","journal-title":"Stereotact Funct Neurosurg"},{"key":"B13","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1179\/174313208X305373","article-title":"Effect of cervical spinal cord stimulation on cerebral glucose metabolism","volume":"30","author":"Clavo","year":"2008","journal-title":"Neurol Res."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2022.968932\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T04:40:27Z","timestamp":1666672827000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2022.968932\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,25]]},"references-count":13,"alternative-id":["10.3389\/fneur.2022.968932"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2022.968932","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,25]]},"article-number":"968932"}}