{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T23:06:10Z","timestamp":1778022370726,"version":"3.51.4"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T00:00:00Z","timestamp":1669939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>An 80-year-old female with a history of diabetes mellitus (DM) and hypertension presented with sudden onset of sequential bilateral visual loss. The best visual acuity was light perception in the right eye and finger counting in the left eye, however, bilateral fundus did not reveal optic disc edema. Diffusion-weighted magnetic resonance imaging (MRI) of the brain revealed acute embolic stroke and diffusion restriction in the posterior portion of both optic nerves. The 24-h Holter monitor showed persistent atrial fibrillation (AF) with rapid ventricular response. The presence of painless and severe visual loss at onset unaccompanied by optic disc edema in the patient with newly detected uncontrolled AF and multiple embolic infarctions favored a diagnosis of non-arteritic posterior ischemic optic neuropathy (PION). The current case contributes to better understanding of PION pathophysiology and associated risk factors, indicating a possible relationship between non-arteritic PION and uncontrolled AF and embolic cerebral infarction.<\/jats:p>","DOI":"10.3389\/fneur.2022.988825","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T13:22:26Z","timestamp":1669987346000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case report: Bilateral posterior ischemic optic neuropathy in a patient with atrial fibrillation and multifocal embolic stroke"],"prefix":"10.3389","volume":"13","author":[{"given":"Jin-Ju","family":"Kang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun-Su","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haeng-Jin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seungbae","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myung-Ja","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun-Young","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.3389\/fmed.2021.618353","article-title":"Risk factors for non-arteritic anterior ischemic optic neuropathy: a large scale meta-analysis","author":"Liu","year":"2021","journal-title":"Front Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2428","DOI":"10.1056\/NEJMra1413352","article-title":"Ischemic optic neuropathies","volume":"372","author":"Biousse","year":"2015","journal-title":"N Engl J Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/S0002-9394(01)01199-0","article-title":"Clinical spectrum of posterior ischemic optic neuropathy","volume":"132","author":"Sadda","year":"2001","journal-title":"Am J Ophthalmol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1038\/sj.eye.6701562","article-title":"Posterior ischaemic optic neuropathy: clinical features, pathogenesis, and management","volume":"18","author":"Hayreh","year":"2004","journal-title":"Eye (Lond)."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12872-018-0825-1","article-title":"Risk of incident atrial fibrillation in patients presenting with retinal artery or vein occlusion: a nationwide cohort study","volume":"18","author":"Christiansen","year":"2018","journal-title":"BMC Cardiovasc Disord."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2446","DOI":"10.1016\/j.ophtha.2016.08.017","article-title":"Demographic, systemic, and ocular factors associated with nonarteritic anterior ischemic optic neuropathy","volume":"123","author":"Cestari","year":"2016","journal-title":"Ophthalmology."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1007\/s00417-013-2399-z","article-title":"Ischemic optic neuropathies - where are we now?","volume":"251","author":"Hayreh","year":"2013","journal-title":"Graefes Arch Clin Exp Ophthalmol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1159\/000309286","article-title":"Posterior ischemic optic neuropathy. 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